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GSTK1 glutathione S-transferase kappa 1 [ Homo sapiens (human) ]

Gene ID: 373156, updated on 12-May-2016
Official Symbol
GSTK1provided by HGNC
Official Full Name
glutathione S-transferase kappa 1provided by HGNC
Primary source
HGNC:HGNC:16906
See related
Ensembl:ENSG00000197448 MIM:602321; Vega:OTTHUMG00000152637
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GST; GST13; hGSTK1; GSTK1-1; GST13-13; GST 13-13
Summary
This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
Orthologs
Location:
7q34
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (143263429..143269129)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (142960506..142966222)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene taste 2 receptor member 40 Neighboring gene uncharacterized LOC105375546 Neighboring gene uncharacterized LOC105375545 Neighboring gene transmembrane protein 139 Neighboring gene caspase 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of glutathione S-transferase kappa 1 (GSTK1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein disulfide oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
glutathione S-transferase kappa 1
Names
GST class-kappa
glutathione S-transferase k1
glutathione S-transferase subunit 13 homolog
NP_001137151.1
NP_001137152.1
NP_001137153.1
NP_057001.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143679.1NP_001137151.1  glutathione S-transferase kappa 1 isoform b

    See identical proteins and their annotated locations for NP_001137151.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded protein (isoform b) is longer compared to isoform a.
    Source sequence(s)
    AL136938, BC063425, BQ436828
    Consensus CDS
    CCDS47730.1
    UniProtKB/Swiss-Prot
    Q9Y2Q3
    Related
    ENSP00000431049, OTTHUMP00000227051, ENST00000479303, OTTHUMT00000327094
    Conserved Domains (1) summary
    cd03021
    Location:6267
    DsbA_GSTK; DsbA family, Glutathione (GSH) S-transferase Kappa (GSTK) subfamily; GSTK is a member of the GST family of enzymes which catalyzes the transfer of the thiol of GSH to electrophilic substrates. It is specifically located in the mitochondria and ...
  2. NM_001143680.1NP_001137152.1  glutathione S-transferase kappa 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region compared to variant 1. The encoded protein (isoform c) is shorter compared to isoform a.
    Source sequence(s)
    AC073342, AK299968, BQ436828
    Consensus CDS
    CCDS47731.1
    UniProtKB/Swiss-Prot
    Q9Y2Q3
    Related
    ENSP00000386944, OTTHUMP00000202121, ENST00000409500, OTTHUMT00000327143
    Conserved Domains (1) summary
    cd03021
    Location:6199
    DsbA_GSTK; DsbA family, Glutathione (GSH) S-transferase Kappa (GSTK) subfamily; GSTK is a member of the GST family of enzymes which catalyzes the transfer of the thiol of GSH to electrophilic substrates. It is specifically located in the mitochondria and ...
  3. NM_001143681.1NP_001137153.1  glutathione S-transferase kappa 1 isoform d

    See identical proteins and their annotated locations for NP_001137153.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the coding region compared to variant 1. The encoded protein (isoform d) is shorter compared to isoform a.
    Source sequence(s)
    AC073342, AK295592, BC001231, BQ436828
    Consensus CDS
    CCDS47732.1
    UniProtKB/Swiss-Prot
    Q9Y2Q3
    Related
    ENSP00000415813, OTTHUMP00000227050, ENST00000443571, OTTHUMT00000379440
    Conserved Domains (1) summary
    cl00388
    Location:6168
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  4. NM_015917.2NP_057001.1  glutathione S-transferase kappa 1 isoform a

    See identical proteins and their annotated locations for NP_057001.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (a).
    Source sequence(s)
    AL136938, BQ436828
    Consensus CDS
    CCDS5877.1
    UniProtKB/Swiss-Prot
    Q9Y2Q3
    UniProtKB/TrEMBL
    Q6FII1
    Related
    ENSP00000351181, OTTHUMP00000202103, ENST00000358406, OTTHUMT00000327091
    Conserved Domains (1) summary
    cd03021
    Location:6211
    DsbA_GSTK; DsbA family, Glutathione (GSH) S-transferase Kappa (GSTK) subfamily; GSTK is a member of the GST family of enzymes which catalyzes the transfer of the thiol of GSH to electrophilic substrates. It is specifically located in the mitochondria and ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    143263429..143269129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    142897388..142903108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)