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    TRIM23 tripartite motif containing 23 [ Homo sapiens ]

    Gene ID: 373, updated on 11-May-2012

    Summary

    Official Symbol
    TRIM23provided by HGNC
    Official Full Name
    tripartite motif containing 23provided by HGNC
    Primary source
    HGNC:660
    See related
    Ensembl:ENSG00000113595; HPRD:03449; MIM:601747; Vega:OTTHUMG00000097802
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARD1; ARFD1; RNF46
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    5q12.3
    Sequence :
    Chromosome: 5; NC_000005.9 (64885507..64920187, complement)
    See TRIM23 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene centromere protein K Neighboring gene peptidylprolyl isomerase domain and WD repeat containing 1 Neighboring gene chromosome 5 open reading frame 44 Neighboring gene small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta Neighboring gene PRAME family member 17 pseudogene Neighboring gene neurolysin (metallopeptidase M3 family)

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P36406 Chromosome 19 open reading frame 57 C19orf57    HPRD  PubMed  
    P36406 Q15438 CYTH1    HPRD  PubMed  
    P36406 Q99418 CYTH2    HPRD  PubMed  
    P36406 FAD synthetase FLAD1    HPRD  PubMed  
    P36406 P55040 GEM    HPRD  PubMed  
    P36406 Q9UJY4 GGA2    HPRD  PubMed  
    P36406 Q8TBB1 LNX1    HPRD  PubMed  
    P36406 Q9Y2N3 POM121    HPRD  PubMed  
    P36406 Q9H4K1 RIBC2    HPRD  PubMed  
    P36406 Q15637 SF1    HPRD  PubMed  
    P36406 P36406 TRIM23    HPRD  PubMed  
    P36406 P14373 TRIM27    HPRD  PubMed  
    P36406 Q14134 TRIM29    HPRD  PubMed  
    P36406 Q9BZY9 TRIM31    HPRD  PubMed  
    P36406 P15622 ZNF250    HPRD  PubMed  
    P36406 Q9P0T4 ZNF581    HPRD  PubMed  
    BioGRID:106868 BioGRID:122157 AKTIP    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:112221 ATXN7    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:122590 C19orf57    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:114688 CYTH1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106868 BioGRID:114687 CYTH2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106868 BioGRID:123221 FLAD1    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:108937 GEM    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:116697 GGA2    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:124219 LNX1    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:115214 POM121    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:117581 RIBC2    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:113368 SF1    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:106868 TRIM23    BioGRID  PubMed Biochemical Activity; Two-hybrid 
    BioGRID:106868 BioGRID:111919 TRIM27    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:115457 TRIM28    BioGRID  PubMed Co-purification 
    BioGRID:106868 BioGRID:117177 TRIM29    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:116257 TRIM31    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:116608 TRIM32    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:125596 TRIM6    BioGRID  PubMed Co-purification 
    BioGRID:106868 BioGRID:113102 TSG101    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106868 BioGRID:113172 UBE2E1    BioGRID  PubMed Biochemical Activity 
    BioGRID:106868 BioGRID:113173 UBE2E2    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:113176 UBE2H    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:113177 UBE2I    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:127156 UBE2U    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:121830 ZNF250    BioGRID  PubMed Two-hybrid 
    BioGRID:106868 BioGRID:119601 ZNF581    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GDP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    GTP catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of catalytic activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein ADP-ribosylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM23
    Names
    E3 ubiquitin-protein ligase TRIM23
    ARF domain protein 1
    RING finger protein 46
    GTP-binding protein ARD-1
    tripartite motif-containing 23
    tripartite motif protein TRIM23
    tripartite motif-containing protein 23
    ADP-ribosylation factor domain protein 1, 64kDa
    ADP-ribosylation factor domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001656.3NP_001647.1  E3 ubiquitin-protein ligase TRIM23 isoform alpha

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha) encodes the longest isoform. It has a unique C-terminus compared to isoforms beta and gamma of this protein.
      Source sequence(s)
      BC022510, BI859501, L04510
      Consensus CDS
      CCDS3987.1
      UniProtKB/Swiss-Prot
      P36406
      Related
      ENSP00000231524, OTTHUMP00000123452, ENST00000231524, OTTHUMT00000215058
      Conserved Domains (6) summary
      cd00021
      Location:126168
      Blast Score: 88
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      smart00502
      Location:226370
      Blast Score: 257
      BBC; B-Box C-terminal domain
      cd04158
      Location:406574
      Blast Score: 898
      ARD1; (ADP-ribosylation factor domain protein 1 (ARD1)
      cl00034
      Location:173219
      Blast Score: 89
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl02600
      Location:288347
      Blast Score: 85
      HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
      cl15348
      Location:3174
      Blast Score: 92
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. NM_033227.2NP_150230.1  E3 ubiquitin-protein ligase TRIM23 isoform beta

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta) is alternatively spliced near the 3' end of the coding region. This introduces a frameshift and the encoded isoform beta has a unique C-terminus compared to isoforms alpha and gamma.
      Source sequence(s)
      AF230398, BC022510, BI859501
      Consensus CDS
      CCDS43322.1
      UniProtKB/Swiss-Prot
      P36406
      Related
      ENSP00000370406, OTTHUMP00000222562, ENST00000381018, OTTHUMT00000370125
      Conserved Domains (6) summary
      cd00021
      Location:126168
      Blast Score: 87
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      smart00502
      Location:226370
      Blast Score: 254
      BBC; B-Box C-terminal domain
      cl00034
      Location:173219
      Blast Score: 88
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl02600
      Location:288347
      Blast Score: 85
      HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
      cl15348
      Location:3174
      Blast Score: 90
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl09099
      Location:406550
      Blast Score: 775
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. NM_033228.2NP_150231.1  E3 ubiquitin-protein ligase TRIM23 isoform gamma

      Status: REVIEWED

      Description
      Transcript Variant: This variant (gamma) is alternatively spliced near the 3' end of the coding region. This introduces a frameshift and the encoded isoform gamma has a unique C-terminus compared to isoforms alpha and beta.
      Source sequence(s)
      AF230399, BC022510, BI859501
      Consensus CDS
      CCDS3986.1
      UniProtKB/Swiss-Prot
      P36406
      Related
      ENSP00000274327, OTTHUMP00000123453, ENST00000274327, OTTHUMT00000215059
      Conserved Domains (5) summary
      smart00502
      Location:226370
      Blast Score: 253
      BBC; B-Box C-terminal domain
      cl00034
      Location:126168
      Blast Score: 86
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cl02600
      Location:288347
      Blast Score: 86
      HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
      cl15348
      Location:3174
      Blast Score: 89
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl09099
      Location:406540
      Blast Score: 712
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      64885507..64920187, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      61841543..61876240, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC008560.6 (58727..93407) None
    genomic CH471137.2 EAW51349.1
      EAW51350.1
      EAW51351.1
    mRNA AF230397.1 AAG50176.1
    mRNA AF230398.1 AAG50177.1
    mRNA AF230399.1 AAG50178.1
    mRNA AI679928.1 None
    mRNA AK292814.1 BAF85503.1
    mRNA BC022510.1 AAH22510.1
    mRNA BI859501.1 None
    mRNA L04510.1 AAA35940.1
    other-genetic DQ893646.2 ABM84572.1
    other-genetic DQ895584.2 ABM86510.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36406.1 GenPept UniProtKB/Swiss-Prot:P36406

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