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    JUP junction plakoglobin [ Homo sapiens ]

    Gene ID: 3728, updated on 20-May-2012

    Summary

    Official Symbol
    JUPprovided by HGNC
    Official Full Name
    junction plakoglobinprovided by HGNC
    Primary source
    HGNC:6207
    See related
    Ensembl:ENSG00000173801; HPRD:01414; MIM:173325; Vega:OTTHUMG00000133494
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DP3; PDGB; PKGB; CTNNG; DPIII; ARVD12
    Summary
    This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    17q21
    Sequence :
    Chromosome: 17; NC_000017.10 (39910859..39942964, complement)

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene gastrin Neighboring gene huntingtin-associated protein 1 Neighboring gene leprecan-like 4 Neighboring gene FK506 binding protein 10, 65 kDa

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P14923 P25054 APC    HPRD  PubMed  
    P14923 P52565 ARHGDIA    HPRD  PubMed  
    P14923 O15169 AXIN1    HPRD  PubMed  
    P14923 Q13489 BIRC3    HPRD  PubMed  
    P14923 Q9Y297 BTRC    HPRD  PubMed  
    P14923 P12830 CDH1    HPRD  PubMed  
    P14923 P55291 CDH15    HPRD  PubMed  
    P14923 P19022 CDH2    HPRD  PubMed  
    P14923 P33151 CDH5    HPRD  PubMed  
    P14923 P35221 CTNNA1    HPRD  PubMed  
    P14923 Q9NSA3 CTNNBIP1    HPRD  PubMed  
    P14923 O60716 CTNND1    HPRD  PubMed  
    P14923 Q08554 DSC1    HPRD  PubMed  
    P14923 Q02487 DSC2    HPRD  PubMed  
    P14923 Q14574 DSC3    HPRD  PubMed  
    P14923 Q02413 DSG1    HPRD  PubMed  
    P14923 Q14126 DSG2    HPRD  PubMed  
    P14923 P32926 DSG3    HPRD  PubMed  
    P14923 P15924 DSP    HPRD  PubMed  
    P14923 P04626 ERBB2    HPRD  PubMed  
    P14923 P16591 FER    HPRD  PubMed  
    P14923 P06241 FYN    HPRD  PubMed  
    P14923 P15941 MUC1    HPRD  PubMed  
    P14923 O00221 NFKBIE    HPRD  PubMed  
    P14923 P16284 PECAM1    HPRD  PubMed  
    P14923 P98161 PKD1    HPRD  PubMed  
    P14923 Q99959 PKP2    HPRD  PubMed  
    P14923 P49768 PSEN1    HPRD  PubMed  
    P14923 Q15678 PTPN14    HPRD  PubMed  
    P14923 P10586 PTPRF    HPRD  PubMed  
    P14923 Q12913 PTPRJ    HPRD  PubMed  
    P14923 Q15262 PTPRK    HPRD  PubMed  
    P14923 Q9H4K1 RIBC2    HPRD  PubMed  
    P14923 P12931 SRC    HPRD  PubMed  
    P14923 P15884 TCF4    HPRD  PubMed  
    P14923 Q9NQB0 TCF7L2    HPRD  PubMed  
    P14923 Q96HA8 WDYHV1    HPRD  PubMed  
    P14923 O95405 ZFYVE9    HPRD  PubMed  
    BioGRID:109931 BioGRID:106821 APC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109931 BioGRID:106889 ARHGDIA    BioGRID  PubMed Two-hybrid 
    BioGRID:109931 BioGRID:106826 BIRC2    BioGRID  PubMed Two-hybrid 
    BioGRID:109931 BioGRID:114457 BTRC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109931 BioGRID:107434 CDH1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109931 BioGRID:107435 CDH2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109931 BioGRID:107436 CDH3    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:109931 BioGRID:107438 CDH5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109931 BioGRID:107876 CTNNA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109931 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109931 BioGRID:121313 CTNNBIP1    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:109931 BioGRID:198631 Cdh1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109931 BioGRID:108157 DSC1    BioGRID  PubMed Two-hybrid 
    BioGRID:109931 BioGRID:108158 DSC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109931 BioGRID:108159 DSC3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109931 BioGRID:108162 DSG1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109931 BioGRID:108163 DSG2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109931 BioGRID:108164 DSG3    BioGRID  PubMed Affinity Capture-Western 
    NP_004406.1 DSP    BIND  PubMed Plakoglobin interacts with desmoplakin. 
    BioGRID:109931 BioGRID:108166 DSP    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109931 BioGRID:199318 Dsc1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109931 BioGRID:199323 Dsg1a    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109931 BioGRID:108276 EGFR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109931 BioGRID:108376 ERBB2    BioGRID  PubMed Far Western 
    BioGRID:109931 BioGRID:108971 GJB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109931 BioGRID:119325 INSIG2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109931 BioGRID:110156 LGALS9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109931 BioGRID:110669 MUC1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:109931 BioGRID:110861 NFKBIE    BioGRID  PubMed Two-hybrid 
    BioGRID:109931 BioGRID:111201 PECAM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109931 BioGRID:116459 PHB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109931 BioGRID:111335 PKP2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    NP_009114.1 PKP3    BIND  PubMed PKP3 interacts with JUP(Pg) 
    BioGRID:109931 BioGRID:116357 PKP3    BioGRID  PubMed Two-hybrid 
    BioGRID:109931 BioGRID:111748 PTPN14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109931 BioGRID:111756 PTPRF    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109931 BioGRID:111760 PTPRK    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109931 BioGRID:119719 RAB8B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109931 BioGRID:117581 RIBC2    BioGRID  PubMed Two-hybrid 
    BioGRID:109931 BioGRID:112795 TCF7L2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109931 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109931 BioGRID:113241 USP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109931 BioGRID:120405 WDYHV1    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RPTP-like protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    alpha-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cadherin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cell wall IC
    Inferred by Curator
    more info
    PubMed 
    structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    adherens junction organization TAS
    Traceable Author Statement
    more info
     
    atrioventricular valve morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell junction assembly TAS
    Traceable Author Statement
    more info
     
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction organization TAS
    Traceable Author Statement
    more info
     
    cellular response to indole-3-methanol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeletal anchoring at plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    desmosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    detection of mechanical stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ectoderm development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endothelial cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    gastrulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    morphogenesis of embryonic epithelium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of Wnt receptor signaling pathway involved in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of heart induction by canonical Wnt receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT negative regulation of transcription from RNA polymerase II promoter IKR
    Inferred from Key Residues
    more info
     
    nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    oocyte development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of canonical Wnt receptor signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    skin development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    Axin-APC-beta-catenin-GSK3B complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    apicolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    catenin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    desmosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fascia adherens IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    gamma-catenin-TCF7L2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT hemidesmosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    internal side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    internal side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    protein-DNA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT transcription factor complex IKR
    Inferred from Key Residues
    more info
     
    zonula adherens IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    zonula adherens ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    junction plakoglobin
    Names
    junction plakoglobin
    catenin gamma
    desmoplakin-3
    gamma-catenin
    desmoplakin III
    catenin (cadherin-associated protein), gamma 80kDa
    catenin (cadherin-associated protein), gamma (80kD)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009090.1 RefSeqGene

      Range
      5001..37106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002230.2NP_002221.1  junction plakoglobin

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC109319
      Consensus CDS
      CCDS11407.1
      UniProtKB/Swiss-Prot
      P14923
      Related
      ENSP00000377508, OTTHUMP00000164738, ENST00000393931, OTTHUMT00000257406
      Conserved Domains (2) summary
      cd00020
      Location:220339
      Blast Score: 165
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd00256
      Location:73242
      Blast Score: 89
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
    2. NM_021991.2NP_068831.1  junction plakoglobin

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate segment in the 3' UTR, compared to transcript variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC109319
      Consensus CDS
      CCDS11407.1
      UniProtKB/Swiss-Prot
      P14923
      Related
      ENSP00000311113, OTTHUMP00000164732, ENST00000310706, OTTHUMT00000257399
      Conserved Domains (2) summary
      cd00020
      Location:220339
      Blast Score: 165
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd00256
      Location:73242
      Blast Score: 89
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      39910859..39942964, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 PATCHES

    Genomic

    1. NW_003571052.1 Reference GRCh37.p5 PATCHES

      Range
      41249..73354, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      35672969..35704921, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC109319.17 (49570..81675) None
    genomic AF233882.1 AAG16727.1
    genomic AF306723.1 AAG16727.1
    genomic AJ249711.1 CAC04246.1
    genomic CH471152.1 EAW60762.1
      EAW60763.1
      EAW60764.1
      EAW60765.1
    genomic CS673474.1 CAP07504.1
    genomic CS690857.1 CAP11472.1
    genomic D50808.1 BAA09435.1
    genomic FB665610.1 CAR97086.1
    genomic GM706822.1 CAT82323.1
    mRNA AK226051.1 None
    mRNA AY243535.1 AAO85780.1
    mRNA BC000441.2 AAH00441.2
    mRNA BC011865.2 AAH11865.1
    mRNA M23410.1 AAA64895.1
    mRNA Z68228.1 CAA92522.1
    other-genetic DQ891420.2 ABM82346.1
    other-genetic DQ894594.2 ABM85520.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14923.3 GenPept UniProtKB/Swiss-Prot:P14923
    Q7KZ86 GenPept UniProtKB/TrEMBL:Q7KZ86

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