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JUNB jun B proto-oncogene [ Homo sapiens (human) ]

Gene ID: 3726, updated on 7-Dec-2014
Official Symbol
JUNBprovided by HGNC
Official Full Name
jun B proto-oncogeneprovided by HGNC
Primary source
HGNC:HGNC:6205
See related
Ensembl:ENSG00000171223; HPRD:01303; MIM:165161; Vega:OTTHUMG00000180373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AP-1
See JUNB in Epigenomics, MapViewer
Location:
19p13.2
Exon count:
1
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (12791496..12793311)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12902310..12904125)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene hook microtubule-tethering protein 2 Neighboring gene microRNA 5684 Neighboring gene peroxiredoxin 2 Neighboring gene ribonuclease H2, subunit A

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of jun B proto-oncogene (JUNB) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to activate release of transforming growth factor beta to culture supernatant, which correlates with increased activity of the AP-1 transcription factor PubMed
matrix gag HIV-1 matrix activates monocytes to produce MCP-1, which depends on the binding activity of AP-1 complexes (c-Fos/JunB) in the MCP-1 promoter PubMed

Go to the HIV-1, Human Interaction Database

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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
decidualization IEA
Inferred from Electronic Annotation
more info
 
embryonic process involved in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
gene expression TAS
Traceable Author Statement
more info
 
labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of nucleic acid-templated transcription TAS
Traceable Author Statement
more info
PubMed 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
osteoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
response to cAMP IEA
Inferred from Electronic Annotation
more info
 
response to corticosterone IEA
Inferred from Electronic Annotation
more info
 
response to cytokine IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to light stimulus IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 
response to progesterone IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription, DNA-templated TAS
Traceable Author Statement
more info
 
transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
 
trophectodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
Preferred Names
transcription factor jun-B
Names
transcription factor jun-B
activator protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002229.2NP_002220.1  transcription factor jun-B

    See proteins identical to NP_002220.1

    Status: VALIDATED

    Source sequence(s)
    BC009466
    Consensus CDS
    CCDS12280.1
    UniProtKB/Swiss-Prot
    P17275
    UniProtKB/TrEMBL
    Q5U079
    Related
    ENSP00000303315, OTTHUMP00000264124, ENST00000302754, OTTHUMT00000451015
    Conserved Domains (2) summary
    cd12193
    Location:269322
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
    pfam03957
    Location:5257
    Jun; Jun-like transcription factor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    12791496..12793311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    12902786..12904601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    12474046..12475861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)