betaTub56D beta-Tubulin at 56D [Drosophila melanogaster] - Gene

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Summary

Official Symbol: betaTub56Dprovided by Flybase
Official Full Name: beta-Tubulin at 56Dprovided by Flybase
Primary source: FLYBASE:FBgn0003887
Locus tag: Dmel_CG9277
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1t; B1t; BETA 56D; beta-tub; beta-Tub; beta-Tub56D; beta-tubulin56D; beta1; beta1-tub; beta1-Tubulin; beta1t; beta1tub; beta1Tub; beta56D; betaTub1; beta[[1]] tubulin; beta[[1]]-tubulin; CG9277; Dmbeta1; Dmel\CG9277; DTB2; T; Tub; Tubulin

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Genomic context

Location :: 56D7-56D8

Sequence :: Chromosome: 2R; NT_033778.3 (15334824..15339122, complement)

See betaTub56D in Epigenomics, MapViewer

Chromosome 2R - NT_033778.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data reveal that beta2-tubulin has robust properties for axoneme assembly, and that axonemal specializations are embedded in both the C-terminal tail and the body of the beta2 molecule.
Title: Axoneme specialization embedded in a "generalist" beta-tubulin.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:62900	BioGRID:59928	Bsg25D	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:62372	CG10139	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:64809	CG10943	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:64574	CG12362	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:64120	CG13287	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:533580	CG14425	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:65853	CG14667	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:66539	CG14718	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:64235	CG14829	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:66938	CG14868	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:61040	CG15141	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:59851	CG15436	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:60755	CG15482	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:58019	CG16721	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:58203	CG2116	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:62819	CG30122	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:57912	CG3081	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:58346	CG3099	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:57711	CG4325	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:67644	CG4771	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:62666	CG4853	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:67579	CG7069	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:67177	CG7357	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:61441	CG7849	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:59076	CG8173	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:59909	CG9121	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:61309	CG9331	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:61314	CG9335	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:66217	CG9797	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:62884	CG9975	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:58538	CkIIbeta	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:65193	Cpr73D	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:58272	Lim1	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:69194	Lk6	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:59275	Mer	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:58080	Pat1	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:67472	Rab11	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:67360	RhoGAP92B	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:71867	Src64B	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:63374	TBPH	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:63197	Vps20	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:1073145	calypso	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62900	BioGRID:62251	cnn	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:64305	eIF4E-5	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:64251	lark	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:68234	mfrn	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:62415	pcs	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:62356	phyl	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:64728	rols	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:61373	tsh	BioGRID	PubMed	Two-hybrid
BioGRID:62900	BioGRID:58557	wisp	BioGRID	PubMed	Two-hybrid

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General gene information

Markers

PMC156124P3 (e-PCR)
- UniSTS:271361

Homology

Homologs of the betaTub56D gene: The betaTub56D gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, and A.thaliana.

Pathways from BioSystems

Chaperonin-mediated protein folding, organism-specific biosystem (from REACTOME)
Chaperonin-mediated protein folding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, organism-specific biosystem (from REACTOME)
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Formation of tubulin folding intermediates by CCT/TriC, organism-specific biosystem (from REACTOME)
Formation of tubulin folding intermediates by CCT/TriC, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Phagosome, organism-specific biosystem (from KEGG)
Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Phagosome, conserved biosystem (from KEGG)
Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Post-chaperonin tubulin folding pathway, organism-specific biosystem (from REACTOME)
Post-chaperonin tubulin folding pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Prefoldin mediated transfer of substrate to CCT/TriC, organism-specific biosystem (from REACTOME)
Prefoldin mediated transfer of substrate to CCT/TriC, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Protein folding, organism-specific biosystem (from REACTOME)
Protein folding, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
GTP binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
GTPase activity	IEA Inferred from Electronic Annotation more info
structural constituent of cytoskeleton	IC Inferred by Curator more info	PubMed
structural constituent of cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info	PubMed
structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
GTP catabolic process	IEA Inferred from Electronic Annotation more info
centrosome duplication	IMP Inferred from Mutant Phenotype more info
microtubule-based movement	IEA Inferred from Electronic Annotation more info
microtubule-based process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
muscle attachment	TAS Traceable Author Statement more info	PubMed
protein polymerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
microtubule	IDA Inferred from Direct Assay more info	PubMed
microtubule	ISS Inferred from Sequence or Structural Similarity more info	PubMed
microtubule	NAS Non-traceable Author Statement more info	PubMed
tubulin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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General protein information

Preferred Names: CG9277 gene product from transcript CG9277-RC

Names: CG9277-PA; CG9277-PB; CG9277-PC; CG9277-PD; beta tubulin; beta-1 tubulin; beta-1-tubulin; beta-Tubulin at 56D; beta-tubulin; beta-tubulin 56D; beta-tubulin-56D; beta1 tubulin; beta1-tubulin; betaTub56D-PA; betaTub56D-PB; betaTub56D-PC; betaTub56D-PD; betatubulin; tubulin

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.3

Range

15334824..15339122, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166357.1 → NP_725897.1 beta-Tubulin at 56D, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A1ZBL1

Related

FBpp0085722, FBtr0086538

Conserved Domains (1) summary

cd02187
Location:1 – 354
Blast Score: 2032

beta_tubulin; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of ...
NM_079071.2 → NP_523795.2 beta-Tubulin at 56D, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24560

Related

FBpp0085720, FBtr0086536

Conserved Domains (2) summary

cd02187
Location:2 – 426
Blast Score: 2447

beta_tubulin; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of ...

PLN00220
Location:1 – 426
Blast Score: 2350

PLN00220; tubulin beta chain; Provisional
NM_166355.2 → NP_725895.2 beta-Tubulin at 56D, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A1ZBL1

Related

FBpp0085723, FBtr0086539

Conserved Domains (1) summary

cd02187
Location:1 – 354
Blast Score: 2032

beta_tubulin; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of ...
NM_166356.1 → NP_725896.1 beta-Tubulin at 56D, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A1ZBL0

Related

FBpp0085721, FBtr0086537

Conserved Domains (2) summary

cd02187
Location:29 – 435
Blast Score: 2340

beta_tubulin; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of ...

PLN00220
Location:29 – 435
Blast Score: 2235

PLN00220; tubulin beta chain; Provisional

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AE013599.4	AAN16132.2
genomic	AE013599.4	AAN16133.1
mRNA	BT003242.1	AAO24999.1
genomic	AE013599.4	AAF57555.1
genomic	AE013599.4	AAF57556.1