My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    ARCN1 archain 1 [ Homo sapiens ]

    Gene ID: 372, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    ARCN1provided by HGNC
    Official Full Name
    archain 1provided by HGNC
    Primary source
    HGNC:649
    See related
    Ensembl:ENSG00000095139; HPRD:02893; MIM:600820; Vega:OTTHUMG00000166340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    COPD
    Summary
    This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or trafficking. [provided by RefSeq, Jul 2008]
    Help top of page

    Genomic context

    Location :
    11q23.3
    Sequence :
    Chromosome: 11; NC_000011.9 (118443102..118473748)
    See ARCN1 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene transmembrane protein 25 Neighboring gene intraflagellar transport 46 homolog (Chlamydomonas) Neighboring gene ribosomal protein L5 pseudogene 30 Neighboring gene pleckstrin homology-like domain, family B, member 1 Neighboring gene trehalase (brush-border membrane glycoprotein)

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068.
    5. Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.

    See all (22) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001646.2 NP_057535.1 COPB1    BIND  PubMed Beta-COP interacts with delta-COP. This interaction was modelled on a demonstrated interaction between rabbit beta-COP and rabbit delta-COP. 
    P48444 P53621 COPA    HPRD  PubMed  
    P48444 P53618 COPB1    HPRD  PubMed  
    P48444 P35606 COPB2    HPRD  PubMed  
    P48444 Q9Y678 COPG1    HPRD  PubMed  
    P48444 Q9UBF2 COPG2    HPRD  PubMed  
    P48444 Q9P299 COPZ2    HPRD  PubMed  
    BioGRID:106867 BioGRID:107710 COPB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106867 BioGRID:198835 Copa    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106867 BioGRID:115156 KEAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106867 BioGRID:115252 PAN2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106867 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the ARCN1 gene: The ARCN1 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • COPI Mediated Transport, organism-specific biosystem (from REACTOME)
      COPI Mediated Transport, organism-specific biosystemSecretory transport depends on membrane-bounded carriers to move protein and lipid between intracellular compartments. The COPI coat has a central role in this process, creating a sorting domain on t...
    • Golgi to ER Retrograde Transport, organism-specific biosystem (from REACTOME)
      Golgi to ER Retrograde Transport, organism-specific biosystemThe anterograde membrane flow from the ER to the Golgi is compensated for by a retrograde pathway. This pathway's functions include the recycling of membrane and proteins to the ER.
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    COPI coating of Golgi vesicle TAS
    Traceable Author Statement
    more info
    		  
    cellular membrane organization TAS
    Traceable Author Statement
    more info
    		  
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    retrograde vesicle-mediated transport, Golgi to ER TAS
    Traceable Author Statement
    more info
    		  
    transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    COPI vesicle coat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    coatomer subunit delta
    Names
    coatomer subunit delta
    delta-COP
    delta-coat protein
    coatomer delta subunit
    coatomer protein delta-COP
    archain vesicle transport protein 1
    coatomer protein complex, subunit delta
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142281.1 → NP_001135753.1  coatomer subunit delta isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1, and encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AA856562, AK304019, AU125652, BC080638, BC093636, CR988766, DB216489
      Consensus CDS
      CCDS44749.1
      UniProtKB/TrEMBL
      B4E1X2
      UniProtKB/TrEMBL
      E9PEU4
      UniProtKB/Swiss-Prot
      P48444
      Related
      ENSP00000376599, OTTHUMP00000232677, ENST00000392859, OTTHUMT00000389274
      Conserved Domains (2) summary
      pfam00928
      Location:183 – 422
      Blast Score: 354
      Adap_comp_sub; Adaptor complexes medium subunit family
      cd09254
      Location:184 – 415
      Blast Score: 943
      AP_delta-COPI_MHD; Mu homology domain (MHD) of adaptor protein (AP) coat protein I (COPI) delta subunit

    2. NM_001655.4 → NP_001646.2  coatomer subunit delta isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA856562, AU125652, BC080638, BC093636, CR988766, DB216489
      Consensus CDS
      CCDS8400.1
      UniProtKB/TrEMBL
      B0YIW5
      UniProtKB/Swiss-Prot
      P48444
      Related
      ENSP00000264028, OTTHUMP00000232680, ENST00000264028, OTTHUMT00000389278
      Conserved Domains (2) summary
      pfam00928
      Location:271 – 510
      Blast Score: 357
      Adap_comp_sub; Adaptor complexes medium subunit family
      cd09254
      Location:272 – 503
      Blast Score: 951
      AP_delta-COPI_MHD; Mu homology domain (MHD) of adaptor protein (AP) coat protein I (COPI) delta subunit

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      118443102..118473748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      114380702..114411245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AP000941.6 (47624..78158) None
    genomic CH471065.1 EAW67397.1
      EAW67398.1
      EAW67399.1
    genomic EF444951.1 ACA05943.1
      ACA05944.1
    mRNA AA856562.1 None
    mRNA AK304019.1 BAG64934.1
    mRNA AK312298.1 BAG35225.1
    mRNA AU125652.1 None
    mRNA BC064936.1 AAH64936.1
    mRNA BC080638.1 None
    mRNA BC093636.1 AAH93636.1
    mRNA BC093638.1 AAH93638.1
    mRNA BI560739.1 None
    mRNA BQ018687.1 None
    mRNA BX640860.1 CAE45922.1
    mRNA CR988766.1 None
    mRNA DB216489.1 None
    mRNA X81197.1 CAA57071.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48444.1 GenPept UniProtKB/Swiss-Prot:P48444
    Q6MZV5 GenPept UniProtKB/TrEMBL:Q6MZV5
    Q6P1Q5 GenPept UniProtKB/TrEMBL:Q6P1Q5
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...