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ARCN1 archain 1 [ Homo sapiens (human) ]

Gene ID: 372, updated on 8-May-2016
Official Symbol
ARCN1provided by HGNC
Official Full Name
archain 1provided by HGNC
Primary source
HGNC:HGNC:649
See related
Ensembl:ENSG00000095139 HPRD:02893; MIM:600820; Vega:OTTHUMG00000166340
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COPD
Summary
This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or trafficking. [provided by RefSeq, Jul 2008]
Orthologs
Location:
11q23.3
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (118572387..118603033)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118443078..118473748)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 46 Neighboring gene uncharacterized LOC105369518 Neighboring gene ribosomal protein L5 pseudogene 30 Neighboring gene pleckstrin homology like domain family B member 1 Neighboring gene microRNA 6716 Neighboring gene trehalase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
cerebellar Purkinje cell layer maturation IEA
Inferred from Electronic Annotation
more info
 
intracellular protein transport TAS
Traceable Author Statement
more info
PubMed 
pigmentation IEA
Inferred from Electronic Annotation
more info
 
retrograde vesicle-mediated transport, Golgi to ER TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
COPI vesicle coat ISS
Inferred from Sequence or Structural Similarity
more info
 
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
transport vesicle TAS
Traceable Author Statement
more info
 
Preferred Names
coatomer subunit delta
Names
archain vesicle transport protein 1
coatomer delta subunit
coatomer protein complex, subunit delta
coatomer protein delta-COP
delta-COP
delta-coat protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142281.1NP_001135753.1  coatomer subunit delta isoform 2

    See identical proteins and their annotated locations for NP_001135753.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1, and encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA856562, AK304019, AU125652, BC080638, BC093636, CR988766, DB216489
    Consensus CDS
    CCDS44749.1
    UniProtKB/Swiss-Prot
    P48444
    Related
    ENSP00000376599, OTTHUMP00000232677, ENST00000392859, OTTHUMT00000389274
    Conserved Domains (1) summary
    cd09254
    Location:184420
    AP_delta-COPI_MHD; Mu homology domain (MHD) of adaptor protein (AP) coat protein I (COPI) delta subunit
  2. NM_001655.4NP_001646.2  coatomer subunit delta isoform 1

    See identical proteins and their annotated locations for NP_001646.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA856562, AU125652, BC080638, BC093636, CR988766, DB216489
    Consensus CDS
    CCDS8400.1
    UniProtKB/Swiss-Prot
    P48444
    UniProtKB/TrEMBL
    B0YIW5
    Related
    ENSP00000264028, OTTHUMP00000232680, ENST00000264028, OTTHUMT00000389278
    Conserved Domains (1) summary
    cd09254
    Location:272508
    AP_delta-COPI_MHD; Mu homology domain (MHD) of adaptor protein (AP) coat protein I (COPI) delta subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    118572387..118603033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271542.2XP_005271599.1  

    Conserved Domains (1) summary
    cd09254
    Location:272414
    AP_delta-COPI_MHD; Mu homology domain (MHD) of adaptor protein (AP) coat protein I (COPI) delta subunit

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    118329760..118360405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)