ITPKB inositol-trisphosphate 3-kinase B [Homo sapiens] - Gene

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Summary

Official Symbol: ITPKBprovided by HGNC
Official Full Name: inositol-trisphosphate 3-kinase Bprovided by HGNC
Primary source: HGNC:6179
See related: Ensembl:ENSG00000143772; HPRD:00942; MIM:147522; Vega:OTTHUMG00000037582
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IP3K; IP3KB; PIG37; IP3K-B; IP3-3KB
Summary: The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 1q42.13

Sequence :: Chromosome: 1; NC_000001.10 (226819391..226926876, complement)

See ITPKB in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IP3KB not only regulates cytoplasmic Ca(2+) signals by phosphorylation of subplasmalemmal and cytoplasmic Ins(1,4,5)P(3) but may also be involved in modulating nuclear Ca(2+) signals generated from these nuclear envelope invaginations.
Title: Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
In each of the three isoforms a nuclear export signal has evolved in the catalytic domain either de novo (IP3K-A) or as a substitute for an earlier evolved corresponding N-terminal signal (IP3K-B and IP3K-C).
Title: Subcellular localisation of human inositol 1,4,5-trisphosphate 3-kinase C: species-specific use of alternative export sites for nucleo-cytoplasmic shuttling indicates divergent roles of the catalytic and N-terminal domains.
results highlight the potential role of the three isoforms of InsP3 3-kinase as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals
Title: The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells.
We aim to summarize the existing information about functionally uncoupled IP(3)R and RyR channels, and to discuss the concept that those channels can participate in Ca(2+)-leak pathways.
Title: Uncoupled IP3 receptor can function as a Ca2+-leak channel: cell biological and pathological consequences.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P27987	Calmodulin 1	CALM1	HPRD	PubMed
P27987	P17612	PRKACA	HPRD	PubMed
P27987	P17252	PRKCA	HPRD	PubMed
P27987	P61289	PSME3	HPRD	PubMed
BioGRID:109912	BioGRID:115492	PSME3	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
calmodulin binding	IEA Inferred from Electronic Annotation more info
inositol-1,4,5-trisphosphate 3-kinase activity	IEA Inferred from Electronic Annotation more info
kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
MAPK cascade	IEA Inferred from Electronic Annotation more info
T cell differentiation	IEA Inferred from Electronic Annotation more info
cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
positive regulation of Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
positive regulation of alpha-beta T cell differentiation	IEA Inferred from Electronic Annotation more info
positive thymic T cell selection	IEA Inferred from Electronic Annotation more info
signal transduction	TAS Traceable Author Statement more info	PubMed

General protein information

Preferred Names: inositol-trisphosphate 3-kinase B

Names: inositol-trisphosphate 3-kinase B; IP3K B; IP3 3-kinase B; insP 3-kinase B; proliferation-inducing protein 37; inositol 1,4,5-trisphosphate 3-kinase B

NP_002212.3

EC 2.7.1.127

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002221.3 → NP_002212.3 inositol-trisphosphate 3-kinase B

Status: REVIEWED

Source sequence(s)

AJ242780, AK313801, AL365444, BC015009, Y18024

Consensus CDS

CCDS1555.1

UniProtKB/TrEMBL

B2R9J0

UniProtKB/Swiss-Prot

P27987

Related

ENSP00000411152, ENST00000429204

Conserved Domains (1) summary

cl12283
Location:726 – 936
Blast Score: 496

IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

226819391..226926876, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

197336497..197443479, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL365444.11	CAH70187.1
		CAH70188.1
genomic	BX537724.1	None
genomic	CH471098.1	EAW69793.1
mRNA	AJ242780.1	CAC40650.1
mRNA	AK025304.1	None
mRNA	AK095901.1	None
mRNA	AK289700.1	BAF82389.1
mRNA	AK313801.1	BAG36537.1
mRNA	AY513281.1	AAT08034.1
mRNA	BC015009.1	AAH15009.1
mRNA	BM972039.1	None
mRNA	BQ434913.1	None
mRNA	BQ434930.1	None
mRNA	X57206.1	CAA40491.1
mRNA	Y18024.2	CAB65055.3
other-genetic	JF432138.1	ADZ15355.1