ITGB7 integrin, beta 7 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: ITGB7provided by HGNC
Official Full Name: integrin, beta 7provided by HGNC
Primary source: HGNC:6162
See related: Ensembl:ENSG00000139626; HPRD:00948; MIM:147559; Vega:OTTHUMG00000169775
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo

Help top of page

Genomic context

Location :: 12q13.13

Sequence :: Chromosome: 12; NC_000012.11 (53585107..53601000, complement)

See ITGB7 in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Consistent with structural predictions, strain increases beta-integrin binding to FLNA, whereas it causes FilGAP to dissociate from FLNA, providing a direct and specific molecular basis for cellular mechanotransduction
Title: Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.
a role for integrin-beta7 in MM-cell adhesion, migration, and BM homing, and pave the way for a novel therapeutic approach targeting this molecule.
Title: Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion.
Data show that integrin beta7 and CCR6 identify four distinct stages of memory CD4+ T cell differentiation.
Title: Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin β7.
findings indicate that alpha4beta7*IgG can be used as a probe for functional MAdCAM-1 expressed on HEVs in GALT and could potentially serve as an anti-inflammatory drug inhibiting GALT-specific lymphocyte migration
Title: An integrin alpha4beta7•IgG heterodimeric chimera binds to MAdCAM-1 on high endothelial venules in gut-associated lymphoid tissue.
Findings suggest that the inactive alpha4beta7 and alpha4beta7 activated by different stimuli have distinct conformations with different structural requirements for MAdCAM-1 binding.
Title: The CC' and DE loops in Ig domains 1 and 2 of MAdCAM-1 play different roles in MAdCAM-1 binding to low- and high-affinity integrin alpha4beta7.
The entry of recently activated CD4-expressing T cells into the bone marrow can occur in a transgenic beta1- and beta7-integrin-independent manner following Listeria monocytogenes infection.
Title: β1 integrin is critical for the maintenance of antigen-specific CD4 T cells in the bone marrow but not long-term immunological memory.
The proportion of all B cells expressing alpha4beta7 was highest in early infancy. Nearly all naive B cells in all age groups expressed alpha4beta7, whereas the expression on class-switched B cells decreased with age.
Title: Development of gut-homing receptors on circulating B cells during infancy.
The specific affinity of gp120 for alpha(4)beta(7) provides a mechanism for HIV-1 to target activated cells that are critical for efficient virus propagation and dissemination following sexual transmission.
Title: The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1.
Mechanical force applied to filamin can expose cryptic integrin binding sites.
Title: The regulation mechanism for the auto-inhibition of binding of human filamin A to integrin.
analysis of the migfilin-filamin interaction and competition with integrin beta 7 tails
Title: Structural basis of the migfilin-filamin interaction and competition with integrin beta tails.

Submit: New GeneRIF Correction See all (21)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
NP_000880.1	AAC68675.1	EED	BIND	PubMed	Integrin beta-7 interacts with WAIT-1.
NP_000880.1	NP_000876.1	ITGA4	BIND	PubMed	Integrin-alpha4 interacts with Integrin-beta7.
P26010	P12830	CDH1	HPRD	PubMed
P26010	O75553	DAB1	HPRD	PubMed
P26010	Q99704	DOK1	HPRD	PubMed
P26010	Embryonic ectoderm development	EED	HPRD	PubMed
P26010	P21333	FLNA	HPRD	PubMed
P26010	P02751	FN1	HPRD	PubMed
P26010	P63244	GNB2L1	HPRD	PubMed
P26010	P13612	ITGA4	HPRD	PubMed
P26010	P38570	ITGAE	HPRD	PubMed
P26010	P26010	ITGB7	HPRD	PubMed
P26010	Q13477	MADCAM1	HPRD	PubMed
P26010	P05771	PRKCB	HPRD	PubMed
P26010	Q05655	PRKCD	HPRD	PubMed
P26010	Tensin like C1 domain containing phosphatase (tensin 2)	TENC1	HPRD	PubMed
P26010	Q9Y490	TLN1	HPRD	PubMed
P26010	P19320	VCAM1	HPRD	PubMed
BioGRID:109901	BioGRID:114265	EED	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:109901	BioGRID:108605	FLNA	BioGRID	PubMed	Reconstituted Complex
BioGRID:109901	BioGRID:108621	FN1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109901	BioGRID:113825	MADCAM1	BioGRID	PubMed	Reconstituted Complex
BioGRID:109901	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cell adhesion	IEA Inferred from Electronic Annotation more info
cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
regulation of immune response	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
integral to membrane	IEA Inferred from Electronic Annotation more info
integrin complex	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: integrin beta-7

Names: integrin beta-7; integrin beta 7 subunit; gut homing receptor beta subunit

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000889.1 → NP_000880.1 integrin beta-7 precursor

Status: PROVISIONAL

Source sequence(s)

S80335

Consensus CDS

CCDS8849.1

UniProtKB/Swiss-Prot

P26010

Related

ENSP00000267082, OTTHUMP00000242065, ENST00000267082, OTTHUMT00000405821

Conserved Domains (4) summary

pfam07965
Location:645 – 718
Blast Score: 192

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:747 – 792
Blast Score: 202

Integrin_b_cyt; Integrin beta cytoplasmic domain

cl00057
Location:50 – 476
Blast Score: 1713

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

cl09941
Location:608 – 635
Blast Score: 81

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p5 Primary Assembly

Range

53585107..53601000, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

50627678..50643108, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC073573.27 (125918..141811)	None
genomic	CH471054.1	EAW96675.1
genomic	L23823.1	AAA36118.1
genomic	S49378.1	AAB23688.1
mRNA	AK298239.1	BAH12742.1
mRNA	AK300960.1	BAH13382.1
mRNA	AK301523.1	BAH13505.1
mRNA	AK311703.1	None
mRNA	BC015916.1	AAH15916.1
mRNA	M62880.1	AAA59185.1
mRNA	M68892.1	AAA59184.1
mRNA	S80335.1	AAB21332.1
other-genetic	DQ895448.2	ABM86374.1
other-genetic	EU176336.1	ABW03787.1