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ITGB7 integrin subunit beta 7 [ Homo sapiens (human) ]

Gene ID: 3695, updated on 26-May-2016
Official Symbol
ITGB7provided by HGNC
Official Full Name
integrin subunit beta 7provided by HGNC
Primary source
HGNC:HGNC:6162
See related
Ensembl:ENSG00000139626 HPRD:00948; MIM:147559; Vega:OTTHUMG00000169775
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Orthologs
Location:
12q13.13
Exon count:
16
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (53191318..53207310, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53585102..53601065, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 4 Neighboring gene cysteine sulfinic acid decarboxylase Neighboring gene zinc finger protein 740 Neighboring gene retinoic acid receptor gamma Neighboring gene major facilitator superfamily domain containing 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of integrin, beta 7 (ITGB7) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Little or no integrin alpha4beta7 binding is detected with multiple HIV-1 gp120s and gp140s, including gp120s from transmitted/founder strains, or when gp120 is produced in CHO, 293T, and 293S/GnT1(-/-) cells PubMed
env The peptide segment at positions 166-178 of the V2 loop of HIV-1 gp120 appears to harbor a cryptic determinant of integrin alpha4beta7 binding on primary human T cells PubMed
env Integrin alpha4beta 7 mediates HIV-1 gp120 binding to natural killer cells. The residues 182-184 in the V2 loop of gp120 is required for the binding between gp120 and integrin alpha4beta7 PubMed
env Treatment of B cells with HIV-1 gp120 upregulates the expression of FCRL4 and limits the proliferative expansion of B cells in an integrin alpha 4/beta 7-dependent manner PubMed
env HIV-1 gp120 binds to human B cells through integrin alpha 4/beta 7 PubMed
env HIV-1 gp120/41 Envelope proteins form a complex with integrin alpha4beta7 and chemokine receptor CCR5 on the CD4-negative gamma-delta T cell membrane, which leads to activation of the p38-caspase pathway and induces the death of gamma-delta cells PubMed
env The gp120-integrin alpha4beta7 complex mediates LFA-1 activation on T cells and increases the efficiency of infection by promoting synapse formation PubMed
env Increased integrin alpha4beta7 affinity is mediated by sequences encoded in gp120 V1/V2 and also influenced by N-linked glycosylation sites located in gp120 C3/V4 PubMed
Envelope surface glycoprotein gp160, precursor env Little or no integrin alpha4beta7 binding is detected with multiple HIV-1140s in human cells PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp120/41 Envelope proteins form a complex with integrin alpha4beta7 and chemokine receptor CCR5 on the CD4-negative gamma-delta T cell membrane, which leads to activation of the p38-caspase pathway and induces the death of gamma-delta cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cell adhesion molecule binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
T cell migration IEA
Inferred from Electronic Annotation
more info
 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-matrix adhesion involved in ameboidal cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte tethering or rolling IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integrin alpha4-beta7 complex IDA
Inferred from Direct Assay
more info
PubMed 
integrin complex TAS
Traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
integrin beta-7
Names
gut homing receptor beta subunit
integrin beta 7 subunit
integrin, beta 7

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000889.2NP_000880.1  integrin beta-7 precursor

    See identical proteins and their annotated locations for NP_000880.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AI804573, DC296007, S80335
    Consensus CDS
    CCDS8849.1
    UniProtKB/Swiss-Prot
    P26010
    Related
    ENSP00000267082, OTTHUMP00000242065, ENST00000267082, OTTHUMT00000405821
    Conserved Domains (3) summary
    pfam08725
    Location:747792
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    cd00198
    Location:152204
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam07965
    Location:645718
    Integrin_B_tail; Integrin beta tail domain

RNA

  1. NR_104181.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks one alternate 5' exon and three alternate 3' exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC073573, AI804573, AK300960, DC296007
    Related
    ENST00000542497, OTTHUMT00000405823

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    53191318..53207310 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268851.2XP_005268908.1  

    See identical proteins and their annotated locations for XP_005268908.1

    UniProtKB/Swiss-Prot
    P26010
    Related
    ENSP00000408741, OTTHUMP00000242064, ENST00000422257, OTTHUMT00000405820
    Conserved Domains (3) summary
    pfam08725
    Location:747792
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    cd00198
    Location:152204
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam07965
    Location:645718
    Integrin_B_tail; Integrin beta tail domain
  2. XM_006719376.2XP_006719439.1  

    Conserved Domains (3) summary
    pfam08725
    Location:747772
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    cd00198
    Location:152204
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam07965
    Location:645718
    Integrin_B_tail; Integrin beta tail domain
  3. XM_005268852.3XP_005268909.1  

    See identical proteins and their annotated locations for XP_005268909.1

    UniProtKB/Swiss-Prot
    P26010
    Related
    ENSP00000455374, OTTHUMP00000250075, ENST00000550743, OTTHUMT00000405822
    Conserved Domains (3) summary
    pfam08725
    Location:747792
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    cd00198
    Location:152204
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    pfam07965
    Location:645718
    Integrin_B_tail; Integrin beta tail domain

RNA

  1. XR_429099.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    53551535..53567526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)