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    mbl muscleblind [ Drosophila melanogaster ]

    Gene ID: 36945, updated on 11-May-2012
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    Summary

    Official Symbol
    mblprovided by Flybase
    Official Full Name
    muscleblindprovided by Flybase
    Primary source
    FLYBASE:FBgn0261642
    Locus tag
    Dmel_CG33197
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10941; CG14477; CG33197; chaste; chst; cht; Dmel\CG33197; l(2)01038; l(2)k01212; l(2)k05507; Mbl; mm; n(2)k07110
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    Genomic context

    Location :
    54A-54A
    Sequence :
    Chromosome: 2R; NT_033778.3 (13153058..13266470)
    See mbl in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene CG43272 gene product from transcript CG43272-RB Neighboring gene CG43108 gene product from transcript CG43108-RA Neighboring gene transfer RNA:CR30232 Neighboring gene transfer RNA:his:56E

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Transcriptional networks for alcohol sensitivity in Drosophila melanogaster. Morozova TV, et al. Genetics, 2011 Apr. PMID 21270389.
    2. Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components. Kucherenko MM, et al. Dev Biol, 2011 Apr 15. PMID 21256839.
    3. Socially-responsive gene expression in male Drosophila melanogaster is influenced by the sex of the interacting partner. Ellis LL, et al. Genetics, 2011 Jan. PMID 20980240.
    4. A conserved motif controls nuclear localization of Drosophila Muscleblind. Fernandez-Costa JM, et al. Mol Cells, 2010 Jul. PMID 20652497.
    5. Genetic analysis of chaste, a new mutation of Drosophila melanogaster characterized by extremely low female sexual receptivity. Juni N, et al. J Neurogenet, 2009. PMID 19169922.

    See all (51) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. This study suggested that the mbl gene function is required for the normal development of neural substrates that regulate female sexual receptivity.
      Title: Genetic analysis of chaste, a new mutation of Drosophila melanogaster characterized by extremely low female sexual receptivity.
    2. Mbl recognizes complex RNA secondary structures.
      Title: RNA binding specificity of Drosophila muscleblind.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:62642 BioGRID:58020 Act5C    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:63895 CG11505    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:65111 CG13040    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:60468 CG13138    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:63225 CG13526    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:65869 CG31550    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:63636 CG3386    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:65115 CG4998    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:67831 CG6454    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:67567 CG7080    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:67223 CG7669    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:63738 CG7967    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:64250 CG8600    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:66231 CG9836    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:59669 CG9883    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:63970 Chd64    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:58246 Cp36    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:65121 Cpr72Ea    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:61367 Ef2b    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:58944 Fur2    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:61885 Jra    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:62642 BioGRID:66080 Mst84Da    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:58107 Nf-YC    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:64973 Pdi    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:60430 Pen    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:68209 Sce    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:60212 TwdlE    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:65755 TwdlF    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:60968 crp    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:67755 eIF4G2    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:64624 fd68A    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:61712 gcl    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:66412 jumu    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:65494 polo    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:61223 ref(2)P    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:57646 ssx    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:60906 stc    BioGRID  PubMed Two-hybrid 
    BioGRID:62642 BioGRID:66603 svp    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:62642 BioGRID:61400 sxc    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the mbl gene: The mbl gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, and zebrafish.

    mobile_element

    • Loc: 13164777-13165120 mobile_element_type = transposon:jockey{}841

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleic acid binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    compound eye photoreceptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    compound eye photoreceptor cell differentiation NAS
    Non-traceable Author Statement
    more info
    		  
    compound eye photoreceptor cell differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    embryo development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    peripheral nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of female receptivity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of female receptivity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    somatic muscle development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  
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    General protein information

    Preferred Names
    CG33197 gene product from transcript CG33197-RL
    Names
    CG33197-PA
    CG33197-PB
    CG33197-PC
    CG33197-PD
    CG33197-PF
    CG33197-PG
    CG33197-PH
    CG33197-PI
    CG33197-PJ
    CG33197-PK
    CG33197-PL
    CG33197-PM
    chaste
    mbl-PA
    mbl-PB
    mbl-PC
    mbl-PD
    mbl-PF
    mbl-PG
    mbl-PH
    mbl-PI
    mbl-PJ
    mbl-PK
    mbl-PL
    mbl-PM
    mindmelt
    muscleblind
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      13153058..13266470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259465.1 → NP_001246394.1  muscleblind, isoform L [Drosophila melanogaster]

      Status: REVIEWED

    2. NM_001259463.1 → NP_001246392.1  muscleblind, isoform I [Drosophila melanogaster]

      Status: REVIEWED

    3. NM_176210.1 → NP_788390.1  muscleblind, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16011
      Related
      FBpp0086146, FBtr0086994

    4. NM_001144217.1 → NP_001137689.1  muscleblind, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZI9
      Related
      FBpp0288738, FBtr0290299

    5. NM_001259464.1 → NP_001246393.1  muscleblind, isoform K [Drosophila melanogaster]

      Status: REVIEWED

    6. NM_001144216.2 → NP_001137688.2  muscleblind, isoform J [Drosophila melanogaster]

      Status: REVIEWED

    7. NM_001259462.1 → NP_001246391.1  muscleblind, isoform H [Drosophila melanogaster]

      Status: REVIEWED

    8. NM_001259466.1 → NP_001246395.1  muscleblind, isoform M [Drosophila melanogaster]

      Status: REVIEWED

    9. NM_176211.1 → NP_788391.1  muscleblind, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16011
      Related
      FBpp0086144, FBtr0086992

    10. NM_176212.1 → NP_788392.1  muscleblind, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16011
      Related
      FBpp0086143, FBtr0086991

    11. NM_001169702.1 → NP_001163173.1  muscleblind, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JH88
      Related
      FBpp0290697, FBtr0301482

    12. NM_176213.1 → NP_788393.1  muscleblind, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16011
      Related
      FBpp0086145, FBtr0086993
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE013599.4 AFH08147.1
    genomic AE013599.4 AFH08145.1
    mRNA AF001536.1 AAC01949.1
    genomic AE013599.4 AAO41357.1
    genomic AE013599.4 ACL83143.1
    genomic AE013599.4 AFH08146.1
    genomic AE013599.4 ACL83142.2
    genomic AE013599.4 AFH08144.1
    genomic AE013599.4 AFH08148.1
    genomic AE013599.4 AAO41358.1
    genomic AE013599.4 AAO41359.1
    mRNA AF001625.1 AAC47757.1
    genomic AE013599.4 ACZ94445.1
    genomic AE013599.4 AAO41360.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAF57881.1 GenPept
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    Additional Links

    Gene LinkOut

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