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    ITGB5 integrin, beta 5 [ Homo sapiens ]

    Gene ID: 3693, updated on 19-May-2012
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    Summary

    Official Symbol
    ITGB5provided by HGNC
    Official Full Name
    integrin, beta 5provided by HGNC
    Primary source
    HGNC:6160
    See related
    Ensembl:ENSG00000082781; HPRD:00949; MIM:147561; Vega:OTTHUMG00000159432
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLJ26658
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    Genomic context

    Location :
    3q21.2
    Sequence :
    Chromosome: 3; NC_000003.11 (124481795..124606144, complement)
    See ITGB5 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S26 pseudogene 22 Neighboring gene microRNA 544b Neighboring gene uridine monophosphate synthetase Neighboring gene enolase 1, (alpha) pseudogene 3 Neighboring gene mucin 13, cell surface associated Neighboring gene HEG homolog 1 (zebrafish)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Targeting ανβ3 and ανβ5 inhibits photon-induced hypermigration of malignant glioma cells. Rieken S, et al. Radiat Oncol, 2011 Oct 6. PMID 21978494.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. CCN3 increases cell motility and MMP-13 expression in human chondrosarcoma through integrin-dependent pathway. Tzeng HE, et al. J Cell Physiol, 2011 Dec. PMID 21344378.
    4. β5 integrin is the major contributor to the αVintegrin-mediated blockade of HIV-1 replication. Ballana E, et al. J Immunol, 2011 Jan 1. PMID 21098231.
    5. Integrin-mediated cell attachment induces a PAK4-dependent feedback loop regulating cell adhesion through modified integrin alpha v beta 5 clustering and turnover. Li Z, et al. Mol Biol Cell, 2010 Oct 1. PMID 20719960.

    See all (79) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. alphanubeta3 and alphanubeta5 have roles in photon-induced hypermigration of malignant glioma cells
      Title: Targeting ανβ3 and ανβ5 inhibits photon-induced hypermigration of malignant glioma cells.
    2. CCN3 enhances the migration of chondrosarcoma cells by increasing MMP-13 expression through the alphavbeta3/alphavbeta5 integrin receptor, FAK, PI3K, Akt, p65, and NF-kappaB signal transduction pathway.
      Title: CCN3 increases cell motility and MMP-13 expression in human chondrosarcoma through integrin-dependent pathway.
    3. The beta5-integrin adhesions contribute to the TGFbeta-induced EMT and the tumorigenic potential of carcinoma cells.
      Title: Role of β5-integrin in epithelial-mesenchymal transition in response to TGF-β.
    4. Data show that knockdown of integrin alphav and erbB3 by small-interfering RNAs significantly inhibited cell migration induced by HRG.
      Title: Significance of integrin αvβ5 and erbB3 in enhanced cell migration and liver metastasis of colon carcinomas stimulated by hepatocyte-derived heregulin.
    5. beta5 integrin is identified as the most important partner of the alpha vitronectin-coupled integrin dimer in monocyte-derived macrophages, thus rendering these cells more susceptible to NF-kappaB-dependent HIV-1 infection.
      Title: β5 integrin is the major contributor to the αVintegrin-mediated blockade of HIV-1 replication.
    6. PAK4 is activated by cell attachment to vitronectin as mediated by PAK4 binding partner integrin alphavbeta5.
      Title: Integrin-mediated cell attachment induces a PAK4-dependent feedback loop regulating cell adhesion through modified integrin alpha v beta 5 clustering and turnover.
    7. Beta1 integrins are required for adhesion and proliferation of induced pluripotent stem cells on Matrigel. On vitronectin, the integrin alphavbeta5 is required for initial attachment, but both alphavbeta5 and beta1 is required for proliferation.
      Title: Roles of integrins in human induced pluripotent stem cell growth on Matrigel and vitronectin.
    8. p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration
      Title: p21-activated kinase 4 phosphorylation of integrin beta5 Ser-759 and Ser-762 regulates cell migration.
    9. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    10. Integrin alphavbeta5 is a primary receptor for adenovirus.
      Title: Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells.
    Submit: New GeneRIF Correction See all (36)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat induced monocyte invasion is inhibited by anti-beta integrin Ab or tissue inhibitor of metalloproteinase (TIMP), indicating an interaction with beta integrins and TIMP PubMed
    tat The vitronectin-binding integrin, alpha v beta 5, is the cell surface protein that binds to the basic RGD domain (amino acids 65-85) of HIV-1 Tat PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002204.2 NP_002201.1 ITGAV    BIND  PubMed ITGAV (alphaV) interacts with ITGB5 (beta5). 
    NP_002204.2 NP_002201.1 ITGAV    BIND  PubMed Integrin-alphaV interacts with integrin-beta5. 
    NP_002204.2 NP_036466.1 MYO10    BIND  PubMed Integrin-beta-5 interacts with Myo10. This interaction was modeled on a demonstrated interaction between human integrin-beta-5 and mouse Myo10. 
    P18084 P08758 ANXA5    HPRD  PubMed  
    P18084 O00622 CYR61    HPRD  PubMed  
    P18084 O75553 DAB1    HPRD  PubMed  
    P18084 P98082 DAB2    HPRD  PubMed  
    P18084 Q99704 DOK1    HPRD  PubMed  
    P18084 Q12929 EPS8    HPRD  PubMed  
    P18084 Q14192 FHL2    HPRD  PubMed  
    P18084 P21333 FLNA    HPRD  PubMed  
    P18084 P63244 GNB2L1    HPRD  PubMed  
    P18084 P08648 ITGA5    HPRD  PubMed  
    P18084 P06756 ITGAV    HPRD  PubMed  
    P18084 Q13352 ITGB3BP    HPRD  PubMed  
    P18084 P18084 ITGB5    HPRD  PubMed  
    P18084 Q14766 LTBP1    HPRD  PubMed  
    P18084 Q9NS15 LTBP3    HPRD  PubMed  
    P18084 Q9HD67 MYO10    HPRD  PubMed  
    P18084 P49757 NUMB    HPRD  PubMed  
    P18084 P41231 P2RY2    HPRD  PubMed  
    P18084 O96013 PAK4    HPRD  PubMed  
    P18084 Palladin PALLD    HPRD  PubMed  
    P18084 Tensin like C1 domain containing phosphatase (tensin 2) TENC1    HPRD  PubMed  
    P18084 Q9Y490 TLN1    HPRD  PubMed  
    P18084 Q13105 ZBTB17    HPRD  PubMed  
    BioGRID:109899 BioGRID:106805 ANXA5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109899 BioGRID:109712 CYR61    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109899 BioGRID:109882 ITGA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109899 BioGRID:116992 ITGB3BP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109899 BioGRID:115586 PAK4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109899 BioGRID:114523 PIAS2    BioGRID  PubMed Two-hybrid 
    BioGRID:109899 BioGRID:111463 PPARD    BioGRID  PubMed Two-hybrid 
    BioGRID:109899 BioGRID:111719 PTK2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109899 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing-Cross presentation, organism-specific biosystem (from REACTOME)
      Antigen processing-Cross presentation, organism-specific biosystemMHC class I molecules generally present peptide antigens derived from proteins synthesized by the cell itself to CD8+ T cells. However, in some circumstances, antigens from extracellular environment ...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Cross-presentation of particulate exogenous antigens (phagosomes), organism-specific biosystem (from REACTOME)
      Cross-presentation of particulate exogenous antigens (phagosomes), organism-specific biosystemDendritic cells (DCs) take up and process exogenous particulate or cell-associated antigens such as microbes or tumor cells for MHC-I cross-presentation. Particulate antigens have been reported to be...
    • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
      Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Dilated cardiomyopathy, conserved biosystem (from KEGG)
      Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
    • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
      Regulation of nuclear SMAD2/3 signaling
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling events mediated by focal adhesion kinase, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by focal adhesion kinase, organism-specific biosystem
      Signaling events mediated by focal adhesion kinase
    • Smooth Muscle Contraction, organism-specific biosystem (from REACTOME)
      Smooth Muscle Contraction, organism-specific biosystemLayers of smooth muscle cells can be found in the walls of numerous organs and tissues within the body. Smooth muscle tissue lacks the striated banding pattern characteristic of skeletal and cardiac ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    antigen processing and presentation of exogenous peptide antigen via MHC class I TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of peptide antigen via MHC class I TAS
    Traceable Author Statement
    more info
    		  
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
    		  
    muscle contraction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    phagocytic vesicle TAS
    Traceable Author Statement
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    integrin beta-5
    Names
    integrin beta-5
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002213.3 → NP_002204.2  integrin beta-5 precursor

      Status: PROVISIONAL

      Source sequence(s)
      BC006541
      Consensus CDS
      CCDS3030.1
      UniProtKB/Swiss-Prot
      P18084
      Related
      ENSP00000296181, OTTHUMP00000215272, ENST00000296181, OTTHUMT00000355286
      Conserved Domains (3) summary
      pfam07965
      Location:635 – 719
      Blast Score: 209
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:743 – 788
      Blast Score: 206
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      cl00057
      Location:35 – 463
      Blast Score: 1730
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      124481795..124606144, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      121856362..121980193, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC022336.12 (54006..166070) None
    genomic AC026342.34 (95200..107484) None
    genomic CH471052.2 EAW79405.1
      EAW79406.1
    genomic EU332848.1 ABY87537.1
    mRNA AK054968.1 None
    mRNA AK130168.1 None
    mRNA AK309551.1 None
    mRNA AK315429.1 BAG37817.1
    mRNA BC006541.2 AAH06541.1
    mRNA J05633.1 AAA59183.1
    mRNA M35011.1 AAA52707.1
    mRNA X53002.1 CAA37188.1
    other-genetic DQ892778.2 ABM83704.1
    other-genetic DQ896025.2 ABM87024.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18084.1 GenPept UniProtKB/Swiss-Prot:P18084
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
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