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    ARAF v-raf murine sarcoma 3611 viral oncogene homolog [ Homo sapiens ]

    Gene ID: 369, updated on 19-May-2012
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    Summary

    Official Symbol
    ARAFprovided by HGNC
    Official Full Name
    v-raf murine sarcoma 3611 viral oncogene homologprovided by HGNC
    Primary source
    HGNC:646
    Locus tag
    RP1-230G1.1
    See related
    Ensembl:ENSG00000078061; HPRD:02405; MIM:311010; Vega:OTTHUMG00000021446
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKS2; A-RAF; ARAF1; RAFA1
    Summary
    This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]
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    Genomic context

    Location :
    Xp11.4-p11.2
    Sequence :
    Chromosome: X; NC_000023.10 (47420516..47431320)
    See ARAF in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 41 Neighboring gene chromosome X open reading frame 24 Neighboring gene nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 1 Neighboring gene synapsin I Neighboring gene TIMP metallopeptidase inhibitor 1 Neighboring gene microRNA 4769

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Li S, et al. Immunity, 2011 Sep 23. PMID 21903422.
    2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    3. A human MAP kinase interactome. Bandyopadhyay S, et al. Nat Methods, 2010 Oct. PMID 20936779.
    4. Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription. Rauch J, et al. Cancer Res, 2010 Feb 15. PMID 20145135.
    5. Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation. Polzien L, et al. J Biol Chem, 2009 Oct 9. PMID 19667065.

    See all (43) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. hnRNP H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription.
      Title: Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription.
    2. Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites.
      Title: Positive regulation of A-RAF by phosphorylation of isoform-specific hinge segment and identification of novel phosphorylation sites.
    3. A-Raf kinase is negatively regulated by trihydrophobin 1
      Title: Trihydrophobin 1 is a new negative regulator of A-Raf kinase.
    4. In a two-hybrid screen of human fetal liver cDNA library, TH1 was detected as a new interaction partner of A-Raf; this specific interaction may have played a critical role in the activation of A-Raf.
      Title: Identification of TH1 as an interaction partner of A-Raf kinase.
    5. mutation analysis of the conserved regions in the ARAF gene in human colorectal adenocarcinoma
      Title: Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas.
    6. A-Raf residues are identified that bind to specific phosphoinositides, possibly as a mechanism to localize the enzyme to particular membrane microdomains rich in these phospholipids.
      Title: Identification of key residues in the A-Raf kinase important for phosphoinositide lipid binding specificity.
    7. These data reveal that B-RAF is an important mediator of neuronal survival, migration, and dendrite formation and that A-RAF cannot fully compensate for these functions.
      Title: Cortical migration defects in mice expressing A-RAF from the B-RAF locus.
    8. A-Raf interacts with MEK1 and activates MEK1 by phosphorylation.
      Title: Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001645.1 NP_000041.2 ASS1    BIND  PubMed A-RAF interacts with ASS. 
    NP_001645.1 NP_000041.2 ASS1    BIND  PubMed A-Raf interacts with ASS. 
    NP_001645.1 NP_003644.2 COPS3    BIND  PubMed A-RAF interacts with SGN3. 
    NP_001645.1 NP_003644.2 COPS3    BIND  PubMed ARAF (A-Raf) interacts with COPS3 (SGN3). 
    NP_001645.1 NP_001866.2 CPS1    BIND  PubMed A-RAF interacts with CPS1. 
    NP_001645.1 NP_001866.2 CPS1    BIND  PubMed A-Raf interacts with CPS1. 
    NP_001645.1 NP_004096.2 EFEMP1    BIND  PubMed A-RAF interacts with FBNL. 
    NP_001645.1 EFEMP1    BIND  PubMed A-Raf interacts with an unspecified isoform of FBNL. 
    NP_001645.1 HRAS    BIND  PubMed ARAF (A-Raf) interacts with an unspecified isoform of HRAS (Ha-Ras). 
    NP_001645.1 NP_002746.1 MAP2K1    BIND  PubMed MEK1 interacts with A-Raf. 
    NP_001645.1 NP_109587.1 MAP2K2    BIND  PubMed MEK2 interacts with A-Raf 
    NP_001645.1 NP_803877.2 NUDT14    BIND  PubMed ARAF (A-Raf) interacts with NUDT14 (hA21). 
    NP_001645.1 NP_060962.2 PBK    BIND  PubMed A-RAF interacts with TOPK/PBK. 
    NP_001645.1 NP_060962.2 PBK    BIND  PubMed A-Raf interacts with TOPK. 
    NP_001645.1 PKM2    BIND  PubMed ARAF (A-Raf) interacts with an unspecified isoform of PKM2 (PyK). 
    NP_001645.1 NP_036601.2 PRPF6    BIND  PubMed A-Raf interacts with TOM. 
    NP_001645.1 NP_004573.2 RABGGTB    BIND  PubMed A-RAF interacts with RABGGT-beta. 
    NP_001645.1 NP_004573.2 RABGGTB    BIND  PubMed A-Raf interacts with RABGGT-beta. 
    NP_001645.1 NP_036382.2 RRAS2    BIND  PubMed A-RAF interacts with R-RAS. 
    NP_001645.1 NP_036382.2 RRAS2    BIND  PubMed A-Raf interacts with R-Ras. 
    NP_001645.1 NP_057481.2 TH1L    BIND  PubMed A-RAF interacts with TH1. 
    NP_001645.1 TH1L    BIND  PubMed A-Raf interacts with an unspecified isoform of TH1. 
    NP_001645.1 NP_006342.2 TIMM44    BIND  PubMed A-RAF interacts with TIMM44. 
    NP_001645.1 NP_006342.2 TIMM44    BIND  PubMed A-Raf interacts with TIMM44. 
    NP_001645.1 NP_001001563.1 TIMM50    BIND  PubMed A-RAF interacts with TIMM50. 
    NP_001645.1 NP_001001563.1 TIMM50    BIND  PubMed ARAF (A-Raf) interacts with TIMM50 (hC22). 
    P10398 P10398 ARAF    HPRD  PubMed  
    P10398 P00966 ASS1    HPRD  PubMed  
    P10398 Q9UNS2 COPS3    HPRD  PubMed  
    P10398 P31327 CPS1    HPRD  PubMed  
    P10398 P67870 CSNK2B    HPRD  PubMed  
    P10398 Q12805 EFEMP1    HPRD  PubMed  
    P10398 P01112 HRAS    HPRD  PubMed  
    P10398 Q53G59 KLHL12    HPRD  PubMed  
    P10398 Q02750 MAP2K1    HPRD  PubMed  
    P10398 P36507 MAP2K2    HPRD  PubMed  
    P10398 O95848 NUDT14    HPRD  PubMed  
    P10398 Q96KB5 PBK    HPRD  PubMed  
    P10398 P09619 PDGFRB    HPRD  PubMed  
    P10398 P27986 PIK3R1    HPRD  PubMed  
    P10398 P14618 PKM2    HPRD  PubMed  
    P10398 P53611 RABGGTB    HPRD  PubMed  
    P10398 O14924 RGS12    HPRD  PubMed  
    P10398 P10301 RRAS    HPRD  PubMed  
    P10398 P62070 RRAS2    HPRD  PubMed  
    P10398 Q8IXH7 TH1L    HPRD  PubMed  
    P10398 O43615 TIMM44    HPRD  PubMed  
    P10398 P61981 YWHAG    HPRD  PubMed  
    BioGRID:106864 BioGRID:106937 ASS1    BioGRID  PubMed Two-hybrid 
    BioGRID:106864 BioGRID:123931 CHD6    BioGRID  PubMed Two-hybrid 
    BioGRID:106864 BioGRID:114103 COPS3    BioGRID  PubMed Two-hybrid 
    BioGRID:106864 BioGRID:107843 CSNK2B    BioGRID  PubMed Two-hybrid 
    BioGRID:106864 BioGRID:108496 EFEMP1    BioGRID  PubMed Two-hybrid 
    BioGRID:106864 BioGRID:109865 IRAK2    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:106864 BioGRID:109873 IRF7    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:106864 BioGRID:121890 KLHL12    BioGRID  PubMed Two-hybrid 
    BioGRID:106864 BioGRID:111591 MAP2K2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106864 BioGRID:134384 MYO18A    BioGRID  PubMed Two-hybrid 
    BioGRID:106864 BioGRID:120971 PBK    BioGRID  PubMed Two-hybrid 
    BioGRID:106864 BioGRID:111313 PIK3R1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106864 BioGRID:117298 PRPF6    BioGRID  PubMed Two-hybrid 
    BioGRID:106864 BioGRID:111814 RABGGTB    BioGRID  PubMed Two-hybrid 
    BioGRID:106864 BioGRID:112151 RRAS    BioGRID  PubMed Two-hybrid 
    BioGRID:106864 BioGRID:109072 SFN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106864 BioGRID:119572 TH1L    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106864 BioGRID:115732 TIMM44    BioGRID  PubMed Two-hybrid 
    BioGRID:106864 BioGRID:125325 TIRAP    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:106864 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106864 BioGRID:113363 YWHAE    BioGRID  PubMed Two-hybrid 
    BioGRID:106864 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106864 BioGRID:113365 YWHAH    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106864 BioGRID:113366 YWHAZ    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
      Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Acute myeloid leukemia, conserved biosystem (from KEGG)
      Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Bladder cancer, organism-specific biosystem (from KEGG)
      Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Bladder cancer, conserved biosystem (from KEGG)
      Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Endometrial cancer, organism-specific biosystem (from KEGG)
      Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Endometrial cancer, conserved biosystem (from KEGG)
      Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
      ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Glioma, organism-specific biosystem (from KEGG)
      Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glioma, conserved biosystem (from KEGG)
      Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Long-term depression, organism-specific biosystem (from KEGG)
      Long-term depression, organism-specific biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
    • Long-term depression, conserved biosystem (from KEGG)
      Long-term depression, conserved biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
    • Long-term potentiation, organism-specific biosystem (from KEGG)
      Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Long-term potentiation, conserved biosystem (from KEGG)
      Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • MAPK Cascade, organism-specific biosystem (from WikiPathways)
      MAPK Cascade, organism-specific biosystem
      MAPK Cascade
    • Melanoma, organism-specific biosystem (from KEGG)
      Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Melanoma, conserved biosystem (from KEGG)
      Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Non-small cell lung cancer, organism-specific biosystem (from KEGG)
      Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Non-small cell lung cancer, conserved biosystem (from KEGG)
      Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Renal cell carcinoma, organism-specific biosystem (from KEGG)
      Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Renal cell carcinoma, conserved biosystem (from KEGG)
      Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
    • Serotonergic synapse, organism-specific biosystem (from KEGG)
      Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
    • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
      Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
    • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
      Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding NAS
    Non-traceable Author Statement
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    		  
    receptor signaling protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein modification process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		  
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
    cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    insoluble fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    serine/threonine-protein kinase A-Raf
    Names
    serine/threonine-protein kinase A-Raf
    Oncogene ARAF1
    proto-oncogene Pks
    proto-oncogene A-Raf-1
    Ras-binding protein DA-Raf
    v-raf murine sarcoma 3611 viral oncogene homolog 1
    A-Raf proto-oncogene serine/threonine-protein kinase
    NP_001645.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016339.1 RefSeqGene

      Range
      4984..15805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256196.1 → NP_001243125.1  serine/threonine-protein kinase A-Raf isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the coding region, which does not affect the reading frame, compared to variant 1. The resulting isoform (2) is 3 aa longer than isoform 1.
      Source sequence(s)
      BC002466, BC007514, DC362427
      UniProtKB/Swiss-Prot
      P10398
      UniProtKB/TrEMBL
      Q96II5
      Conserved Domains (4) summary
      cd00029
      Location:99 – 144
      Blast Score: 147
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01816
      Location:20 – 91
      Blast Score: 303
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      pfam00069
      Location:314 – 567
      Blast Score: 613
      Pkinase; Protein kinase domain
      cl09925
      Location:317 – 567
      Blast Score: 475
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001256197.1 → NP_001243126.1  serine/threonine-protein kinase A-Raf isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in an immediate translation termination and a novel 3' UTR compared to variant 1. The resulting isoform (3) has a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AB158254, CA424869, DC362427
      UniProtKB/TrEMBL
      Q5H9B2
      Conserved Domains (2) summary
      cd00029
      Location:99 – 144
      Blast Score: 130
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01816
      Location:20 – 91
      Blast Score: 297
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases

    3. NM_001654.4 → NP_001645.1  serine/threonine-protein kinase A-Raf isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the predominant isoform (1).
      Source sequence(s)
      BC002466, DC362427
      Consensus CDS
      CCDS35232.1
      UniProtKB/Swiss-Prot
      P10398
      Related
      ENSP00000366244, OTTHUMP00000023212, ENST00000377045, OTTHUMT00000056418
      Conserved Domains (4) summary
      cd00029
      Location:99 – 144
      Blast Score: 147
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01816
      Location:20 – 91
      Blast Score: 303
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      pfam00069
      Location:311 – 564
      Blast Score: 613
      Pkinase; Protein kinase domain
      cl09925
      Location:314 – 564
      Blast Score: 475
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p5 Primary Assembly

      Range
      47420516..47431320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      45132748..45143540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic CH471164.1 EAW59310.1
      EAW59311.1
      EAW59312.1
    genomic L24038.1 AAA65219.1
    genomic U01337.1 AAB03517.1
    genomic Z84466.2 CAI42468.1
      CAI42469.1
    mRNA AB158254.1 BAE66645.1
    mRNA AB208831.1 BAD92068.1
    mRNA AF052136.1 None
    mRNA AK130043.1 None
    mRNA AK297453.1 BAG59877.1
    mRNA AK300975.1 BAG62597.1
    mRNA AK307747.1 None
    mRNA BC002466.2 AAH02466.1
    mRNA BC007514.2 AAH07514.1
    mRNA BT019864.1 AAV38667.1
    mRNA CA424869.1 None
    mRNA DA264472.1 None
    mRNA DC362427.1 None
    mRNA M13829.1 AAB08754.1
    mRNA X04790.1 CAA28476.1
    other-genetic DQ892656.2 ABM83582.1
    other-genetic DQ895896.2 ABM86822.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10398.2 GenPept UniProtKB/Swiss-Prot:P10398
    Q59HC8 GenPept UniProtKB/TrEMBL:Q59HC8
    Q5H9B2 GenPept UniProtKB/TrEMBL:Q5H9B2
    Q96II5 GenPept UniProtKB/TrEMBL:Q96II5
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

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