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    ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) [ Homo sapiens ]

    Gene ID: 3689, updated on 19-May-2012
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    Summary

    Official Symbol
    ITGB2provided by HGNC
    Official Full Name
    integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)provided by HGNC
    Primary source
    HGNC:6155
    See related
    Ensembl:ENSG00000160255; HPRD:02506; MIM:600065; Vega:OTTHUMG00000090257
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1
    Summary
    The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    21q22.3
    Sequence :
    Chromosome: 21; NC_000021.8 (46305868..46348753, complement)
    See ITGB2 in Epigenomics, MapViewer

    Chromosome 21 - NC_000021.8Genomic Context describing neighboring genes Neighboring gene SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) Neighboring gene pituitary tumor-transforming 1 interacting protein Neighboring gene uncharacterized LOC100505746 Neighboring gene chromosome 21 open reading frame 67 Neighboring gene family with sequence similarity 207, member A

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Molecular basis for complement recognition by integrin αXβ2. Chen X, et al. Proc Natl Acad Sci U S A, 2012 Mar 20. PMID 22393018.
    2. CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi. Hawley KL, et al. Proc Natl Acad Sci U S A, 2012 Jan 24. PMID 22232682.
    3. A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1. Pillay J, et al. J Clin Invest, 2012 Jan 3. PMID 22156198.
    4. Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design. Mahalingam B, et al. J Immunol, 2011 Dec 15. PMID 22095715.
    5. Structures and interaction analyses of integrin αMβ2 cytoplasmic tails. Chua GL, et al. J Biol Chem, 2011 Dec 23. PMID 22052909.

    See all (326) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. analysis of complement recognition by integrin alphaXbeta2
      Title: Molecular basis for complement recognition by integrin αXβ2.
    2. complement receptor 3 is a MyD88-independent phagocytic receptor for Borrelia burgdorferi, and also participates in the modulation of the proinflammatory output of macrophages.
      Title: CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi.
    3. release of hydrogen peroxide the neutrophils into the immunological synapse between neutrophils and T cells mediated the suppression of T cell proliferation and required neutrophil expression of the integrin Mac-1
      Title: A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1.
    4. structures and interaction analyses of integrin alphaMbeta2 cytoplasmic tails
      Title: Structures and interaction analyses of integrin αMβ2 cytoplasmic tails.
    5. the cross-talk between neutrophils and NK cells is mediated by ICAM-3 and CD11d/CD18, respectively.
      Title: On the potential involvement of CD11d in co-stimulating the production of interferon-γ by natural killer cells upon interaction with neutrophils via intercellular adhesion molecule-3.
    6. Denticity of the Asp/Glu ligand of integrin CD11b/CD18 can modify divalent cation (calcium or magnesium) selectivity at the metal ion-dependent adhesion site in neutrophils, and hence integrin function.
      Title: Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design.
    7. Data found that blocking CD11b, CD18, or CD54 on the endothelial progenitor cells (EPC) surface with monoclonal antibodies protected EPCs, enhancing its survival.
      Title: Trauma-activated polymorphonucleated leukocytes damage endothelial progenitor cells: probable role of CD11b/CD18-CD54 interaction and release of reactive oxygen species.
    8. Activation through the T cell receptor results in phosphorylation of LFA-1 that leads to engagement of Tiam1 and Rac1
      Title: TCR-induced activation of LFA-1 involves signaling through Tiam1.
    9. crystallographic data on the structure of CD11c/CD18 and prediction of the secondary structure of the C4BP oligomerization domain, we show that epitopes bound by KIM185 in these proteins are unlikely to share any major structural similarity
      Title: The role of higher-order protein structure in supporting binding by heteroclitic monoclonal antibodies: the monoclonal antibody KIM185 to CD18 also binds C4-binding protein.
    10. analysis of beta2-integrin and intercellular adhesion molecule 1 binding kinetics in tumor cell adhesion to leukocytes and endothelial cells by a gas-driven micropipette assay
      Title: Determining beta2-integrin and intercellular adhesion molecule 1 binding kinetics in tumor cell adhesion to leukocytes and endothelial cells by a gas-driven micropipette assay.
    Submit: New GeneRIF Correction See all (231)
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    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Leukocyte adhesion deficiency

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-mediated ICAM-1 expression has functional significance, as it enhances the ability of monocytic cells to bind to gp120-stimulated human astrocytes in an ICAM-1/beta 2 integrin-dependent fashion PubMed
    env Anti-CD18 monoclonal antibodies completely block cell fusion between HIV-1 infected U-937 cells and MT-4 T cells, indicating participation of CD18, or of the protein complex CD11a-c/CD18, in addition to CD4, in the infection and cytopathic effect of HIV-1 PubMed
    Tat tat HIV-1 Tat induced monocyte invasion is inhibited by anti-beta integrin Ab or tissue inhibitor of metalloproteinase (TIMP), indicating an interaction with beta integrins and TIMP PubMed
    tat HIV-1 Tat inhibits calcium influx and impairs CAMKII activation elicited via LFA-1 (beta 2 integrin) in NK cells PubMed
    tat HIV-1 Tat treatment of monocytes upregulates beta 2 integrins and anti-beta 2 Abs inhibits Tat induced adhesion of monocytes to endothelial monolayers, suggesting a mechanism where monocytes could be inappropriately activated by HIV-1 Tat PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_000202.1 CYTH1    BIND  PubMed Integrin beta-2 interacts with cytohesin-1. 
    NP_000202.1 NP_005484.2 RANBP9    BIND  PubMed RanBPM interacts with beta-2 integrin LFA-1. 
    P05107 P08571 CD14    HPRD  PubMed  
    P05107 Q15762 CD226    HPRD  PubMed  
    P05107 P27701 CD82    HPRD  PubMed  
    P05107 Q9UNS2 COPS3    HPRD  PubMed  
    P05107 Q15438 CYTH1    HPRD  PubMed  
    P05107 Q99418 CYTH2    HPRD  PubMed  
    P05107 O75553 DAB1    HPRD  PubMed  
    P05107 Q99704 DOK1    HPRD  PubMed  
    P05107 Q9NQ30 ESM1    HPRD  PubMed  
    P05107 P06734 FCER2    HPRD  PubMed  
    P05107 Q14192 FHL2    HPRD  PubMed  
    P05107 P22083 FUT4    HPRD  PubMed  
    P05107 P63244 GNB2L1    HPRD  PubMed  
    P05107 P00738 HP    HPRD  PubMed  
    P05107 P05362 ICAM1    HPRD  PubMed  
    P05107 P13598 ICAM2    HPRD  PubMed  
    P05107 P32942 ICAM3    HPRD  PubMed  
    P05107 Q14773 ICAM4    HPRD  PubMed  
    P05107 Q9UMF0 ICAM5    HPRD  PubMed  
    P05107 Q13418 ILK    HPRD  PubMed  
    P05107 Q13349 ITGAD    HPRD  PubMed  
    P05107 P11215 ITGAM    HPRD  PubMed  
    P05107 P20702 ITGAX    HPRD  PubMed  
    P05107 P05107 ITGB2    HPRD  PubMed  
    P05107 P01042 KNG1    HPRD  PubMed  
    P05107 P49757 NUMB    HPRD  PubMed  
    P05107 P17252 PRKCA    HPRD  PubMed  
    P05107 P05771 PRKCB    HPRD  PubMed  
    P05107 Q05655 PRKCD    HPRD  PubMed  
    P05107 P24723 PRKCH    HPRD  PubMed  
    P05107 P24158 PRTN3    HPRD  PubMed  
    P05107 Q05397 PTK2    HPRD  PubMed  
    P05107 Q14289 PTK2B    HPRD  PubMed  
    P05107 Q96S59 RANBP9    HPRD  PubMed  
    P05107 P35241 RDX    HPRD  PubMed  
    P05107 P43405 SYK    HPRD  PubMed  
    P05107 Q9Y490 TLN1    HPRD  PubMed  
    P05107 O95498 VNN2    HPRD  PubMed  
    BioGRID:109895 BioGRID:115908 CD226    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109895 BioGRID:114688 CYTH1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109895 BioGRID:108565 FHL2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109895 BioGRID:115671 GNB2L1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109895 BioGRID:109610 ICAM1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109895 BioGRID:109887 ITGAD    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109895 BioGRID:109889 ITGAL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109895 BioGRID:110026 KNG1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109895 BioGRID:248286 P2rx7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109895 BioGRID:111345 PLAUR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109895 BioGRID:108480 PTK2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109895 BioGRID:112717 SYK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109895 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109895 BioGRID:114394 VNN2    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • CXCR3-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR3-mediated signaling events, organism-specific biosystem
      CXCR3-mediated signaling events
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • HIF-1-alpha transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      HIF-1-alpha transcription factor network, organism-specific biosystem
      HIF-1-alpha transcription factor network
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-5 Signaling Pathway, organism-specific biosystemInterleukin-5 belongs to the family of cytokines, which includes IL-3 and GM-CSF. It signals through a receptor complex comprising of an IL-5 receptor alpha subunit (IL5RA), and a common beta chain w...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
    • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Paxillin-dependent events mediated by a4b1, organism-specific biosystem (from Pathway Interaction Database)
      Paxillin-dependent events mediated by a4b1, organism-specific biosystem
      Paxillin-dependent events mediated by a4b1
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
      Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
      Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Staphylococcus aureus infection, conserved biosystem (from KEGG)
      Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
    • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
      amb2 Integrin signaling, organism-specific biosystem
      amb2 Integrin signaling

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    glycoprotein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell-cell signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    inflammatory response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    integrin-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    leukocyte cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
    		  
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
    		  
    neutrophil chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of cell shape NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of immune response TAS
    Traceable Author Statement
    more info
    		  
    regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integrin complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    integrin beta-2
    Names
    integrin beta-2
    integrin beta chain, beta 2
    complement receptor C3 beta-subunit
    complement receptor C3 subunit beta
    leukocyte cell adhesion molecule CD18
    leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C
    cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta
    cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007270.2 RefSeqGene

      Range
      5001..47886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_76

    mRNA and Protein(s)

    1. NM_000211.3 → NP_000202.2  integrin beta-2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK128344, AL773603, BC005861, DA200537, M15395
      Consensus CDS
      CCDS13716.1
      UniProtKB/Swiss-Prot
      P05107
      Related
      ENSP00000303242, ENST00000302347
      Conserved Domains (3) summary
      pfam07965
      Location:622 – 700
      Blast Score: 204
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:724 – 768
      Blast Score: 193
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      cl00057
      Location:32 – 447
      Blast Score: 1666
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. NM_001127491.1 → NP_001120963.1  integrin beta-2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK095992, AK128344, AL773603, AL844908, BC005861, M15395
      Consensus CDS
      CCDS13716.1
      UniProtKB/Swiss-Prot
      P05107
      Related
      ENSP00000347279, OTTHUMP00000115278, ENST00000355153, OTTHUMT00000206565
      Conserved Domains (3) summary
      pfam07965
      Location:622 – 700
      Blast Score: 204
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:724 – 768
      Blast Score: 193
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      cl00057
      Location:32 – 447
      Blast Score: 1666
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000021.8 Reference GRCh37.p5 Primary Assembly

      Range
      46305868..46348753, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000153.1 Alternate HuRef

      Range
      31679225..31721357, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF016894.1 AAL14027.1
    genomic AL163300.2 CAB90553.1
    genomic AL773603.1 (82038..91850) None
    genomic AL844907.1 None
    genomic AL844908.1 None
    genomic CH471079.2 EAX09381.1
      EAX09382.1
      EAX09383.1
      EAX09384.1
      EAX09385.1
    genomic X64072.1 CAA45427.1
    mRNA AB208909.1 BAD92146.1
    mRNA AK095992.1 BAG53190.1
    mRNA AK097216.1 None
    mRNA AK097864.1 None
    mRNA AK128344.1 None
    mRNA AK222505.1 BAD96225.1
    mRNA AK303488.1 BAG64523.1
    mRNA AU279404.1 None
    mRNA BC005861.2 AAH05861.1
    mRNA BC021077.1 AAH21077.1
    mRNA DA200537.1 None
    mRNA L78790.1 AAL40068.1
    mRNA M15395.1 AAA59490.1
    mRNA S81234.1 AAB21404.1
    mRNA Y00057.1 CAA68266.1
    other-genetic DQ892684.2 ABM83610.1
    other-genetic DQ895927.2 ABM86853.1
    other-genetic EU832617.1 ACE87708.1
    other-genetic EU832689.1 ACE87021.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05107.2 GenPept UniProtKB/Swiss-Prot:P05107
    Q59H50 GenPept UniProtKB/TrEMBL:Q59H50
    Q6PJ75 GenPept UniProtKB/TrEMBL:Q6PJ75
    Q8WWJ8 GenPept UniProtKB/TrEMBL:Q8WWJ8
    Q96PT7 GenPept UniProtKB/TrEMBL:Q96PT7
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