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    ITGAV integrin, alpha V [ Homo sapiens ]

    Gene ID: 3685, updated on 19-May-2012
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    Summary

    Official Symbol
    ITGAVprovided by HGNC
    Official Full Name
    integrin, alpha Vprovided by HGNC
    Primary source
    HGNC:6150
    See related
    Ensembl:ENSG00000138448; HPRD:01903; MIM:193210; Vega:OTTHUMG00000132635
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD51; MSK8; VNRA; VTNR; DKFZp686A08142
    Summary
    ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
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    Genomic context

    Location :
    2q31-q32
    Sequence :
    Chromosome: 2; NC_000002.11 (187454790..187545628)
    See ITGAV in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 28 pseudogene Neighboring gene zinc finger CCCH-type containing 15 Neighboring gene divergent-paired related homeobox pseudogene 1 Neighboring gene family with sequence similarity 171, member B Neighboring gene zinc finger, SWIM-type containing 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Crosstalk between integrin αvβ3 and estrogen receptor-α is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. Meng R, et al. PLoS One, 2011. PMID 22132110.
    2. αv integrin: a new gastrin target in human pancreatic cancer cells. Cayrol C, et al. World J Gastroenterol, 2011 Oct 28. PMID 22110279.
    3. ATM-mediated DNA damage signals mediate immune escape through integrin-αvβ3-dependent mechanisms. Jinushi M, et al. Cancer Res, 2012 Jan 1. PMID 22094875.
    4. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    5. Targeting ανβ3 and ανβ5 inhibits photon-induced hypermigration of malignant glioma cells. Rieken S, et al. Radiat Oncol, 2011 Oct 6. PMID 21978494.

    See all (355) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Performed molecular dynamics to simulate forced unbending of a complete integrin alpha(v)beta ectodomain in both unliganded and liganded forms.
      Title: Molecular dynamics simulations of forced unbending of integrin α(v)β₃.
    2. Integrin alphavbeta3 promotes vitronectin gene expression in human ovarian cancer cells by implicating rel transcription factors
      Title: Integrin αvβ3 promotes vitronectin gene expression in human ovarian cancer cells by implicating rel transcription factors.
    3. chemokine receptor 7 regulates cell adhesion and migration via integrin alpha v beta 3 in metastatic squamous cell carcinoma of the head and neck
      Title: Chemokine receptor 7 promotes cell migration and adhesion in metastatic squamous cell carcinoma of the head and neck by activating integrin αvβ3.
    4. Integrin alphavbeta3 and Lewis Y, which is contained within it, are expressed in secretory-stage endometrial tissue.
      Title: Difucosylated oligosaccharide Lewis Y is contained within integrin αvβ3 on RL95-2 cells and required for endometrial receptivity.
    5. data demonstrated that (18)F-fluciclatide detected changes in tumor uptake after acute antiangiogenic therapy markedly earlier than any significant volumetric changes were observable.
      Title: Monitoring tumor response to antiangiogenic sunitinib therapy with 18F-fluciclatide, an 18F-labeled αVbeta3-integrin and αV beta5-integrin imaging agent.
    6. PET of alphavbeta3-integrin and alphavbeta5-integrin expression with 18F-fluciclatide for assessment of response to targeted therapy.
      Title: PET of αvbeta3-integrin and αvbeta5-integrin expression with 18F-fluciclatide for assessment of response to targeted therapy: ready for prime time?
    7. demonstrate that alphaVbeta3 ligation results in sustained increases of PI3 kinase/Akt-dependent binding of transcription factor NF-kappaB to DNA.
      Title: αVβ3 integrin regulates macrophage inflammatory responses via PI3 kinase/Akt-dependent NF-κB activation.
    8. Results show that the tyrosine phosphatase protein-tyrosine phosphatase mu dephosphorylated PIPKIgamma and thus canceled the PIPKIgamma-dependent activation of integrin alpha(v)beta(3) by blocking the interaction of integrin alpha(v)beta(3) with talin.
      Title: Involvement of nectin in inactivation of integrin alpha(v)beta(3) after the establishment of cell-cell adhesion.
    9. The role of alpha(v)beta(3) and Fas as the mediators of streptococcal pyrogenic exotoxin (SPE) B-induced apoptosis is described.
      Title: Streptococcal pyrogenic exotoxin B-induced apoptosis in A549 cells is mediated through alpha(v)beta(3) integrin and Fas.
    10. Preincubation of macrophages with HMGB1 decreased their ability to engulf apoptotic neutrophils or thymocytes. Soluble alphavbeta3 integrin, but not soluble alphavbeta5 integrin, prevented this inhibition.
      Title: HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin.
    Submit: New GeneRIF Correction See all (250)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 interacts with CD4 and alphavbeta3 in peripheral blood monocyte-derived macrophages; neutralizing antibodies against the alphavbeta3 integrin interfere with the coprecipitation of alphavbeta3 with an anti-gp120 antibody PubMed
    Tat tat HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src PubMed
    tat IFN-gamma interacts with HIV-1 Tat to induce endothelial cells to proliferate and invade the extracellular matrix by upregulating the receptors for Tat (integrins alpha-5-beta-1 and alpha-v-beta-3), suggesting Tat and IFN-gamma play major roles in AIDS-KS PubMed
    tat The arginine-glycine-aspartic acid (RGD) sequence present at the carboxy-terminal of HIV-1 Tat mediates vascular cell and monocyte migration and invasion by binding to the alpha-5-beta-1 and alpha-v-beta-3 integrins PubMed
    tat The RGD-containing domain of exogenous HIV-1 Tat inhibits the engulfment of apoptotic bodies by dendritic cells through an interaction with integrin alpha v beta 3 PubMed
    tat HIV-1 Tat induces angiogenesis and cooperates in the development of AIDS-associated Kaposi sarcoma as a result of interactions with integrins alpha-5-beta-1 and alpha-v-beta 3 PubMed
    tat Interaction of HIV-1 Tat with alpha 5, beta 1, and alpha v subunits of surface integrin receptors mediates activation of CD4+ T cells PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002201.1 NP_002202.2 ITGB1    BIND  PubMed Integrin-alphaV interacts with Integrin-beta1 
    NP_002201.1 NP_000203.2 ITGB3    BIND  PubMed Integrin-alphaV interacts with Integrin-beta3. 
    NP_002201.1 NP_002204.2 ITGB5    BIND  PubMed ITGAV (alphaV) interacts with ITGB5 (beta5). 
    NP_002201.1 NP_002204.2 ITGB5    BIND  PubMed Integrin-alphaV interacts with integrin-beta5. 
    NP_002201.1 NP_000879.2 ITGB6    BIND  PubMed Integrin-alphaV interacts with Integrin-beta6. 
    NP_002201.1 NP_002205.1 ITGB8    BIND  PubMed Integrin-alphaV interacts with Integrin-beta8. 
    NP_002201.1 NP_003237.2 THBS1    BIND  PubMed Alpha-V-beta3 interacts with TS-1. This interaction was modeled on a demonstrated interaction between pig alpha-V-beta3 and human TS-1. 
    P06756 Q13443 ADAM9    HPRD  PubMed  
    P06756 Q9Y5C1 ANGPTL3    HPRD  PubMed  
    P06756 Q9Y679 AUP1    HPRD  PubMed  
    P06756 P25311 AZGP1    HPRD  PubMed  
    P06756 P27797 CALR    HPRD  PubMed  
    P06756 Q08722 CD47    HPRD  PubMed  
    P06756 O00622 CYR61    HPRD  PubMed  
    P06756 O43854 EDIL3    HPRD  PubMed  
    P06756 P25116 F2R    HPRD  PubMed  
    P06756 Q14773 ICAM4    HPRD  PubMed  
    P06756 P05556 ITGB1    HPRD  PubMed  
    P06756 P05106 ITGB3    HPRD  PubMed  
    P06756 P18084 ITGB5    HPRD  PubMed  
    P06756 P18564 ITGB6    HPRD  PubMed  
    P06756 P26012 ITGB8    HPRD  PubMed  
    P06756 P32004 L1CAM    HPRD  PubMed  
    P06756 P50281 MMP14    HPRD  PubMed  
    P06756 P08253 MMP2    HPRD  PubMed  
    P06756 P14543 NID1    HPRD  PubMed  
    P06756 P41231 P2RY2    HPRD  PubMed  
    P06756 O96013 PAK4    HPRD  PubMed  
    P06756 P16234 PDGFRA    HPRD  PubMed  
    P06756 P60201 PLP1    HPRD  PubMed  
    P06756 Q05397 PTK2    HPRD  PubMed  
    P06756 P10451 SPP1    HPRD  PubMed  
    P06756 P01137 TGFB1    HPRD  PubMed  
    P06756 P04216 THY1    HPRD  PubMed  
    BioGRID:109891 BioGRID:107031 AUP1    BioGRID  PubMed Two-hybrid 
    BioGRID:109891 BioGRID:107262 CALR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109891 BioGRID:109712 CYR61    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113288 BioGRID:109824 ILK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109891 BioGRID:109896 ITGB3    BioGRID  PubMed Co-crystal Structure 
    BioGRID:109891 BioGRID:110094 L1CAM    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109891 BioGRID:110918 NOV    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109891 BioGRID:111368 PLP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109891 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing-Cross presentation, organism-specific biosystem (from REACTOME)
      Antigen processing-Cross presentation, organism-specific biosystemMHC class I molecules generally present peptide antigens derived from proteins synthesized by the cell itself to CD8+ T cells. However, in some circumstances, antigens from extracellular environment ...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Cross-presentation of particulate exogenous antigens (phagosomes), organism-specific biosystem (from REACTOME)
      Cross-presentation of particulate exogenous antigens (phagosomes), organism-specific biosystemDendritic cells (DCs) take up and process exogenous particulate or cell-associated antigens such as microbes or tumor cells for MHC-I cross-presentation. Particulate antigens have been reported to be...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
      Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Dilated cardiomyopathy, conserved biosystem (from KEGG)
      Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
    • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Integrins in angiogenesis, organism-specific biosystem (from Pathway Interaction Database)
      Integrins in angiogenesis, organism-specific biosystem
      Integrins in angiogenesis
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • Nectin adhesion pathway, organism-specific biosystem (from Pathway Interaction Database)
      Nectin adhesion pathway, organism-specific biosystem
      Nectin adhesion pathway
    • Osteoblast Signaling, organism-specific biosystem (from WikiPathways)
      Osteoblast Signaling, organism-specific biosystem
      Osteoblast Signaling
    • Osteopontin-mediated events, organism-specific biosystem (from Pathway Interaction Database)
      Osteopontin-mediated events, organism-specific biosystem
      Osteopontin-mediated events
    • PDGFR-alpha signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      PDGFR-alpha signaling pathway, organism-specific biosystem
      PDGFR-alpha signaling pathway
    • PECAM1 interactions, organism-specific biosystem (from REACTOME)
      PECAM1 interactions, organism-specific biosystemPECAM-1/CD31 is a member of the immunoglobulin superfamily (IgSF) and has been implicated to mediate the adhesion and trans-endothelial migration of T-lymphocytes into the vascular wall, T cell activ...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • S1P1 pathway, organism-specific biosystem (from Pathway Interaction Database)
      S1P1 pathway, organism-specific biosystem
      S1P1 pathway
    • S1P3 pathway, organism-specific biosystem (from Pathway Interaction Database)
      S1P3 pathway, organism-specific biosystem
      S1P3 pathway
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signal transduction by L1, organism-specific biosystem (from REACTOME)
      Signal transduction by L1, organism-specific biosystemBesides adhesive roles in cell cell interaction, L1 functions as a signal transducing receptor providing neurons with cues from their environment for axonal growth and guidance. L1 associates with be...
    • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
      Signaling events mediated by VEGFR1 and VEGFR2
    • Signaling events mediated by focal adhesion kinase, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by focal adhesion kinase, organism-specific biosystem
      Signaling events mediated by focal adhesion kinase
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to insulin-like growth factor I binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to opsonin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase C alpha binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to protein kinase C binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transforming growth factor beta binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    angiogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    antigen processing and presentation of exogenous peptide antigen via MHC class I TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of peptide antigen via MHC class I TAS
    Traceable Author Statement
    more info
    		  
    axon guidance TAS
    Traceable Author Statement
    more info
    		  
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    blood vessel development IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell-matrix adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    entry of bacterium into host cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    entry of symbiont into host cell by promotion of host phagocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    entry of virus into host cell TAS
    Traceable Author Statement
    more info
    		 PubMed 
    integrin-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    leukocyte migration TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of lipid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of lipoprotein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of low-density lipoprotein particle receptor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of macrophage derived foam cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of osteoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of apoptotic cell clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of phagocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    		  
    cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    integrin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integrin complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    phagocytic vesicle TAS
    Traceable Author Statement
    more info
    		  
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    integrin alpha-V
    Names
    integrin alpha-V
    integrin alphaVbeta3
    vitronectin receptor subunit alpha
    antigen identified by monoclonal antibody L230
    integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144999.1 → NP_001138471.1  integrin alpha-V isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC017101, AK302990, BC047454
      Consensus CDS
      CCDS46471.1
      UniProtKB/TrEMBL
      B7Z883
      Related
      ENSP00000404291, OTTHUMP00000205400, ENST00000433736, OTTHUMT00000334604
      Conserved Domains (3) summary
      pfam08441
      Location:421 – 868
      Blast Score: 1208
      Integrin_alpha2; Integrin alpha
      pfam13517
      Location:214 – 279
      Blast Score: 105
      VCBS; Family description
      cl15299
      Location:321 – 375
      Blast Score: 154
      FG-GAP; FG-GAP repeat

    2. NM_001145000.1 → NP_001138472.1  integrin alpha-V isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the coding region compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1.
      Source sequence(s)
      AC017101, AK309711, BC047454, BC136442, BC144100
      Consensus CDS
      CCDS46470.1
      UniProtKB/TrEMBL
      B7ZLX0
      UniProtKB/Swiss-Prot
      P06756
      Related
      ENSP00000364042, OTTHUMP00000205399, ENST00000374907, OTTHUMT00000334603
      Conserved Domains (3) summary
      pfam08441
      Location:431 – 878
      Blast Score: 1205
      Integrin_alpha2; Integrin alpha
      pfam13517
      Location:224 – 289
      Blast Score: 106
      VCBS; Family description
      cl15299
      Location:331 – 385
      Blast Score: 154
      FG-GAP; FG-GAP repeat

    3. NM_002210.3 → NP_002201.1  integrin alpha-V isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC017101, AK309711, BC047454, BC136442
      Consensus CDS
      CCDS2292.1
      UniProtKB/Swiss-Prot
      P06756
      Related
      ENSP00000261023, OTTHUMP00000163473, ENST00000261023, OTTHUMT00000255882
      Conserved Domains (3) summary
      pfam08441
      Location:467 – 914
      Blast Score: 1209
      Integrin_alpha2; Integrin alpha
      pfam13517
      Location:260 – 325
      Blast Score: 104
      VCBS; Family description
      cl15299
      Location:367 – 421
      Blast Score: 153
      FG-GAP; FG-GAP repeat

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      187454790..187545628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      179314524..179405485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC017101.10 AAY24257.1
    genomic AF251818.1 AAG03000.1
    genomic AF251819.1 AAG03000.1
    genomic AF251820.1 AAG03000.1
    genomic AF251821.1 AAG03000.1
    genomic AF251822.1 AAG03000.1
    genomic AF251823.1 AAG03000.1
    genomic AF251824.1 AAG03000.1
    genomic AF251825.1 AAG03000.1
    genomic AF251826.1 AAG03000.1
    genomic AF251827.1 AAG03000.1
    genomic AF251828.1 AAG03000.1
    genomic AF251829.1 AAG03000.1
    genomic AF251830.1 AAG03000.1
    genomic AF251831.1 AAG03000.1
    genomic AF251832.1 AAG03000.1
    genomic AF251833.1 AAG03000.1
    genomic AF251834.1 AAG03000.1
    genomic AF251835.1 AAG03000.1
    genomic AF251836.1 AAG03000.1
    genomic AF251837.1 AAG03000.1
    genomic AF251838.1 AAG03000.1
    genomic AF251839.1 AAG03000.1
    genomic AF251840.1 AAG03000.1
    genomic AF251841.1 AAG03000.1
    genomic CH471058.2 EAX10933.1
      EAX10934.1
    genomic EU332844.1 ABY87533.1
    genomic U07375.1 AAA61631.1
    mRNA AB209894.1 BAD93131.1
    mRNA AK302550.1 BAG63819.1
    mRNA AK302990.1 BAH13869.1
    mRNA AK309711.1 None
    mRNA BC047454.1 None
    mRNA BC072686.1 None
    mRNA BC126231.1 AAI26232.1
    mRNA BC136442.1 AAI36443.1
    mRNA BC144100.1 AAI44101.1
    mRNA BQ129340.1 None
    mRNA EF560727.1 ABQ59037.1
    mRNA M14648.1 AAA36808.1
    mRNA N83286.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06756.2 GenPept UniProtKB/Swiss-Prot:P06756
    Help top of page

    Additional Links

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