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    Sema-2a [ Drosophila melanogaster ]

    Gene ID: 36846, updated on 10-May-2012
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    Summary

    Official Symbol
    Sema-2aprovided by Flybase
    Primary source
    FLYBASE:FBgn0011260
    Locus tag
    Dmel_CG4700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    112/40; BcDNA:LD09561; CG4700; CT14922; D-Sema II; D-Sema-II; D-Sema2a; D-semaII; D-SemaII; Dmel\CG4700; dSema-II; Dsema-II; l(2)03021; sema 2a; sema II; sema-2a; sema-II; sema2a; Sema2a; semaII; SemaII
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    Genomic context

    Location :
    53C6-53C7
    Sequence :
    Chromosome: 2R; NT_033778.3 (12387701..12420934)
    See Sema-2a in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene Sperm-Leucylaminopeptidase 8 Neighboring gene CG7813 gene product from transcript CG7813-RA Neighboring gene CG4750 gene product from transcript CG4750-RA Neighboring gene Syntrophin-like 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. GlycoFly: a database of Drosophila N-linked glycoproteins identified using SPEG--MS techniques. Baycin-Hizal D, et al. J Proteome Res, 2011 Jun 3. PMID 21480662.
    2. Positional cues in the Drosophila nerve cord: semaphorins pattern the dorso-ventral axis. Zlatic M, et al. PLoS Biol, 2009 Jun 16. PMID 19547742.
    3. Overexpression screen in Drosophila identifies neuronal roles of GSK-3 beta/shaggy as a regulator of AP-1-dependent developmental plasticity. Franciscovich AL, et al. Genetics, 2008 Dec. PMID 18832361.
    4. Genetic modifier screens reveal new components that interact with the Drosophila dystroglycan-dystrophin complex. Kucherenko MM, et al. PLoS One, 2008 Jun 11. PMID 18545683.
    5. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.

    See all (41) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. PlexB is a receptor for the secreted semaphorin Sema-2a
      Title: Drosophila Plexin B is a Sema-2a receptor required for axon guidance.
    2. These data support a model in which Sema2a, while being secreted from oenocytes, represses axon extension from the sensory neuron cell body, but only in regions in direct contact with oenocytes.
      Title: Semaphorin 2a secreted by oenocytes signals through plexin B and plexin A to guide sensory axons in the Drosophila embryo.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:62559 BioGRID:625223 ATbp    BioGRID  PubMed Two-hybrid 
    BioGRID:62559 BioGRID:66659 Arp87C    BioGRID  PubMed Two-hybrid 
    BioGRID:62559 BioGRID:65377 CG14089    BioGRID  PubMed Two-hybrid 
    BioGRID:62559 BioGRID:65880 CG2931    BioGRID  PubMed Two-hybrid 
    BioGRID:62559 BioGRID:66110 CG3014    BioGRID  PubMed Two-hybrid 
    BioGRID:62559 BioGRID:59869 CG3225    BioGRID  PubMed Two-hybrid 
    BioGRID:62559 BioGRID:60160 CG5155    BioGRID  PubMed Two-hybrid 
    BioGRID:62559 BioGRID:72482 CycK    BioGRID  PubMed Two-hybrid 
    BioGRID:62559 BioGRID:57881 Fas2    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:62559 BioGRID:63578 Kr    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:62559 BioGRID:58759 NetA    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:62559 BioGRID:71867 Src64B    BioGRID  PubMed Two-hybrid 
    BioGRID:62559 BioGRID:63141 Vrp1    BioGRID  PubMed Two-hybrid 
    BioGRID:62559 BioGRID:63994 ago    BioGRID  PubMed Two-hybrid 
    BioGRID:62559 BioGRID:59046 f    BioGRID  PubMed Two-hybrid 
    BioGRID:62559 BioGRID:67237 fru    BioGRID  PubMed Two-hybrid 
    BioGRID:62559 BioGRID:60379 gcm2    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the Sema-2a gene: The Sema-2a gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, and mosquito.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    adult behavior NAS
    Non-traceable Author Statement
    more info
    		  
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    axon guidance NAS
    Non-traceable Author Statement
    more info
    		  
    drinking behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    flight behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    salivary gland development IMP
    Inferred from Mutant Phenotype
    more info
    		  
    synaptic target inhibition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    synaptic target inhibition NAS
    Non-traceable Author Statement
    more info
    		  
    visual behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    extracellular region NAS
    Non-traceable Author Statement
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    CG4700 gene product from transcript CG4700-RC
    Names
    CG4700-PA
    CG4700-PB
    CG4700-PC
    CG4700-PD
    D-Semaphorin II
    Sema-2a
    Sema-2a-PA
    Sema-2a-PB
    Sema-2a-PC
    Sema-2a-PD
    semaphorin
    semaphorin 2a
    semaphorin II
    semiphorin
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      12387701..12420934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166178.2 → NP_725586.1  Sema-2a, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24323
      Related
      FBpp0086236, FBtr0087088
      Conserved Domains (4) summary
      cd04979
      Location:546 – 637
      Blast Score: 205
      Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain of semaphorin
      smart00630
      Location:41 – 471
      Blast Score: 1060
      Sema; semaphorin domain
      cd11238
      Location:39 – 496
      Blast Score: 2032
      Sema_2A; The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A)
      cl02601
      Location:500 – 542
      Blast Score: 82
      PSI; Plexin repeat

    2. NM_058159.4 → NP_477507.1  Sema-2a, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24323
      Related
      FBpp0086238, FBtr0087090
      Conserved Domains (4) summary
      cd04979
      Location:573 – 664
      Blast Score: 206
      Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain of semaphorin
      smart00630
      Location:68 – 498
      Blast Score: 1059
      Sema; semaphorin domain
      cd11238
      Location:66 – 523
      Blast Score: 2026
      Sema_2A; The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A)
      cl02601
      Location:527 – 569
      Blast Score: 81
      PSI; Plexin repeat

    3. NM_134303.3 → NP_599130.1  Sema-2a, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24323
      Related
      FBpp0086237, FBtr0087089
      Conserved Domains (4) summary
      cd04979
      Location:573 – 664
      Blast Score: 206
      Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain of semaphorin
      smart00630
      Location:68 – 498
      Blast Score: 1059
      Sema; semaphorin domain
      cd11238
      Location:66 – 523
      Blast Score: 2026
      Sema_2A; The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A)
      cl02601
      Location:527 – 569
      Blast Score: 81
      PSI; Plexin repeat

    4. NM_206134.1 → NP_995856.1  Sema-2a, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24323
      Related
      FBpp0089268, FBtr0087091
      Conserved Domains (4) summary
      cd04979
      Location:550 – 641
      Blast Score: 206
      Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain of semaphorin
      smart00630
      Location:68 – 475
      Blast Score: 1006
      Sema; semaphorin domain
      cd11238
      Location:66 – 500
      Blast Score: 1928
      Sema_2A; The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A)
      cl02601
      Location:504 – 546
      Blast Score: 82
      PSI; Plexin repeat
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE013599.4 AAM68500.1
    mRNA AY095026.1 AAM11354.1
    mRNA AY128437.1 AAM75030.1
    genomic AE013599.4 AAF57990.1
    genomic AE013599.4 AAF57989.1
    genomic AE013599.4 AAS64837.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MLF1.1 GenPept
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    Additional Links

    Gene LinkOut

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