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CG8060 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36824, updated on 4-Apr-2024

Summary

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Official Symbol
CG8060provided by FlyBase
Primary source
FLYBASE:FBgn0034113
Locus tag
Dmel_CG8060
See related
AllianceGenome:FB:FBgn0034113
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG8060
Summary
Predicted to enable protein tyrosine kinase inhibitor activity. Predicted to be involved in negative regulation of protein tyrosine kinase activity. Predicted to be located in nucleoplasm. Orthologous to human IBTK (inhibitor of Bruton tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
53B4-53B4; 2-79 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16316313..16320732, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12203818..12208237, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45232 Neighboring gene Autophagy-related 9 Neighboring gene NADPH oxidase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mes2, a MADF-containing transcription factor essential for Drosophila development. Zimmermann G, et al. Dev Dyn, 2006 Dec. PMID 17029287
  2. Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome. Glatter T, et al. Mol Syst Biol, 2011 Nov 8. PMID 22068330, Free PMC Article
  3. The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling. Xu C, et al. Cell Rep, 2019 Jan 15. PMID 30650359, Free PMC Article
  4. Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. Krauchunas AR, et al. Dev Biol, 2012 Oct 1. PMID 22884528, Free PMC Article
  5. In vivo analysis of proteomes and interactomes using Parallel Affinity Capture (iPAC) coupled to mass spectrometry. Rees JS, et al. Mol Cell Proteomics, 2011 Jun. PMID 21447707, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein tyrosine kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in negative regulation of protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG8060-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16316313..16320732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137273.3 → NP_611117.2  uncharacterized protein Dmel_CG8060 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611117.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZAE2, Q95R60
    Related
    FBpp0086322
    Conserved Domains (9) summary
    smart00225
    Location:697 → 798
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cd00204
    Location:46 → 138
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14821
    Location:798 → 834
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00415
    Location:147 → 195
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam00651
    Location:684 → 795
    BTB; BTB/POZ domain
    pfam12796
    Location:95 → 138
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:57 → 111
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:56 → 87
    ANK; ANK repeat [structural motif]
    cl02518
    Location:547 → 635
    BTB; BTB/POZ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZAE2 A1ZAE2
Q95R60 Q95R60

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