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ITGAD integrin subunit alpha D [ Homo sapiens (human) ]

Gene ID: 3681, updated on 26-May-2016
Official Symbol
ITGADprovided by HGNC
Official Full Name
integrin subunit alpha Dprovided by HGNC
Primary source
HGNC:HGNC:6146
See related
Ensembl:ENSG00000156886 MIM:602453; Vega:OTTHUMG00000176614
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADB2; CD11D
Summary
This gene belongs to the beta-2 integrin family of membrane glycoproteins, which are are composed of non-covalently linked alpha and beta subunits to form a heterodimer. It encodes the alpha subunit of the cell surface heterodimers and is involved in the activation and adhesion functions of leukocytes. The gene is located about 11kb downstream of the integrin subunit alpha X gene, another member of the integrin family. It is expressed in the tissue and circulating myeloid leukocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Orthologs
Location:
16p11.2
Exon count:
32
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (31393241..31426513)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31404633..31437826)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha M Neighboring gene integrin subunit alpha X pseudogene Neighboring gene integrin subunit alpha X Neighboring gene cytochrome c oxidase subunit 6A2 Neighboring gene zinc finger protein 843

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ39841

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
extracellular matrix organization TAS
Traceable Author Statement
more info
 
heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response NAS
Non-traceable Author Statement
more info
PubMed 
integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IC
Inferred by Curator
more info
PubMed 
integrin complex TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
integrin alpha-D
Names
CD11 antigen-like family member D
beta-2 integrin alphaD subunit
leukointegrin alpha D

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050624.1 RefSeqGene

    Range
    5072..38265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001318185.1NP_001305114.1  integrin alpha-D isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB208945, U37028
    UniProtKB/Swiss-Prot
    Q13349
    UniProtKB/TrEMBL
    Q59H14
    Conserved Domains (4) summary
    smart00191
    Location:453495
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11251139
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:6151028
    Integrin_alpha2; Integrin alpha
  2. NM_005353.2NP_005344.2  integrin alpha-D isoform 2 precursor

    See identical proteins and their annotated locations for NP_005344.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.
    Source sequence(s)
    AB208945
    Consensus CDS
    CCDS32438.1
    UniProtKB/Swiss-Prot
    Q13349
    UniProtKB/TrEMBL
    Q59H14
    Related
    ENSP00000373854, OTTHUMP00000254645, ENST00000389202, OTTHUMT00000432836
    Conserved Domains (4) summary
    smart00191
    Location:453509
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11241138
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:6141027
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    31393241..31426513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545845.1XP_011544147.1  

    Conserved Domains (2) summary
    smart00191
    Location:464506
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
  2. XM_011545848.1XP_011544150.1  

    Conserved Domains (2) summary
    smart00191
    Location:464506
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
  3. XM_011545846.1XP_011544148.1  

    Conserved Domains (2) summary
    smart00191
    Location:464506
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
  4. XM_011545843.1XP_011544145.1  

    Conserved Domains (3) summary
    smart00191
    Location:464506
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:6261018
    Integrin_alpha2; Integrin alpha
  5. XM_011545835.1XP_011544137.1  

    Conserved Domains (4) summary
    smart00191
    Location:464506
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11531167
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:6261056
    Integrin_alpha2; Integrin alpha
  6. XM_011545837.1XP_011544139.1  

    Conserved Domains (4) summary
    smart00191
    Location:464506
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11521166
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:6261055
    Integrin_alpha2; Integrin alpha
  7. XM_011545844.1XP_011544146.1  

    Conserved Domains (4) summary
    smart00191
    Location:464506
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:961975
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:581864
    Integrin_alpha2; Integrin alpha
  8. XM_011545842.1XP_011544144.1  

    Conserved Domains (4) summary
    smart00191
    Location:377419
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:10661080
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:539969
    Integrin_alpha2; Integrin alpha
  9. XM_011545839.1XP_011544141.1  

    Conserved Domains (4) summary
    smart00191
    Location:464506
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11361150
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:6261039
    Integrin_alpha2; Integrin alpha
  10. XM_011545836.1XP_011544138.1  

    Conserved Domains (4) summary
    smart00191
    Location:464520
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11521166
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:6251055
    Integrin_alpha2; Integrin alpha
  11. XM_011545838.1XP_011544140.1  

    Conserved Domains (4) summary
    smart00191
    Location:453495
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11421156
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:6151045
    Integrin_alpha2; Integrin alpha
  12. XM_011545840.1XP_011544142.1  

    Conserved Domains (4) summary
    smart00191
    Location:453495
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11251139
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:6151028
    Integrin_alpha2; Integrin alpha
  13. XM_011545841.1XP_011544143.1  

    Conserved Domains (4) summary
    smart00191
    Location:453509
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:11231137
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:6141026
    Integrin_alpha2; Integrin alpha
  14. XM_011545847.1XP_011544149.1  

    Conserved Domains (3) summary
    cd01469
    Location:149324
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam00357
    Location:741755
    Integrin_alpha; Integrin alpha cytoplasmic region
    pfam08441
    Location:356644
    Integrin_alpha2; Integrin alpha

RNA

  1. XR_950791.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    32723321..32756513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)