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    ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) [ Homo sapiens ]

    Gene ID: 3678, updated on 19-May-2012
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    Summary

    Official Symbol
    ITGA5provided by HGNC
    Official Full Name
    integrin, alpha 5 (fibronectin receptor, alpha polypeptide)provided by HGNC
    Primary source
    HGNC:6141
    See related
    Ensembl:ENSG00000161638; HPRD:00627; MIM:135620; Vega:OTTHUMG00000169841
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FNRA; CD49e; VLA5A
    Summary
    The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    12q11-q13
    Sequence :
    Chromosome: 12; NC_000012.11 (54789045..54813050, complement)
    See ITGA5 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 84 Neighboring gene zinc finger protein 385A Neighboring gene gametocyte specific factor 1 Neighboring gene NCK-associated protein 1-like

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. ZEB2 upregulates integrin α5 expression through cooperation with Sp1 to induce invasion during epithelial-mesenchymal transition of human cancer cells. Nam EH, et al. Carcinogenesis, 2012 Mar. PMID 22227038.
    2. αVβ3-integrin relocalizes nectin1 and routes herpes simplex virus to lipid rafts. Gianni T, et al. J Virol, 2012 Mar. PMID 22171266.
    3. Rv2468c, a novel Mycobacterium tuberculosis protein that costimulates human CD4+ T cells through VLA-5. Li Q, et al. J Leukoc Biol, 2012 Feb. PMID 22158781.
    4. The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration. Zech T, et al. J Cell Sci, 2011 Nov 15. PMID 22114305.
    5. Integrin alphavbeta6 promotes tumor tolerance in colorectal cancer. Yang SB, et al. Cancer Immunol Immunother, 2012 Mar. PMID 21913024.

    See all (226) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. ZEB2 was found to activate integrin alpha5 and vimentin promoters by interacting with and activating transcription factor Sp1, suggesting that cooperation between ZEB2 and Sp1 represents a novel mechanism of mesenchymal gene activation during epithelia...
      Title: ZEB2 upregulates integrin α5 expression through cooperation with Sp1 to induce invasion during epithelial-mesenchymal transition of human cancer cells.
    2. Data suggest that colorectal cancer (CRC)-derived integrin alphavbeta6 is involved in the establishment of tumor immune tolerance in local tissues.
      Title: Integrin alphavbeta6 promotes tumor tolerance in colorectal cancer.
    3. WASH and Arp2/3 regulates integrin alpha5beta1-mediated invasive cell migration.
      Title: The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration.
    4. alphaVbeta3-integrin relocalizes nectin1 to lipid rafts, independently of herpes simplex virus 1.
      Title: αVβ3-integrin relocalizes nectin1 and routes herpes simplex virus to lipid rafts.
    5. Rv2468c engaged integrin VLA-5 (alpha5beta1) on CD4+ T cells through its FN-like RGD motif GRDGSPK.
      Title: Rv2468c, a novel Mycobacterium tuberculosis protein that costimulates human CD4+ T cells through VLA-5.
    6. The endoproteolytic cleavage of alphav subunits is necessary for alphavbeta5/beta6 integrin to control alpha2beta1 function and could thus play an essential role in colon cancer cell migration.
      Title: αv integrin processing interferes with the cross-talk between αvβ5/β6 and α2β1 integrins.
    7. Integrin alpha5beta1 might involves the abnormal proliferation and migration of A549 cells through mediating ERK signal transduction pathway.
      Title: [Effect of Integrin α5β1-mediated ERK signal pathway on proliferation and migration of A549 cells].
    8. investigation of role of ITGA5 in cancer: MMP9 activity is induced by EGF/FN in breast cancer cells by the activation of multiple signaling pathways (FAK, PI3 K, and ERK); integrin receptor alpha5beta1 (ITGA5/ITGB1) is required in these processes.
      Title: Epigallocatechin-3-gallate (EGCG) downregulates EGF-induced MMP-9 in breast cancer cells: involvement of integrin receptor α5β1 in the process.
    9. The expression of the alpha5 gene in human uveal melanoma cell lines, was characterized.
      Title: Suppression of α5 gene expression is closely related to the tumorigenic properties of uveal melanoma cell lines.
    10. Data show that cagL-Y58E59 H. pylori infection predisposed an upward shift in integrin alpha5beta1 in the corpus, leading to more severe corpus chronic inflammation.
      Title: H. pylori cagL amino acid sequence polymorphism Y58E59 induces a corpus shift of gastric integrin α5β1 related with gastric carcinogenesis.
    Submit: New GeneRIF Correction See all (146)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates VLA-5 (integrin alpha 5) cell surface receptor levels in thymic epithelial cells PubMed
    tat IFN-gamma interacts with HIV-1 Tat to induce endothelial cells to proliferate and invade the extracellular matrix by upregulating the receptors for Tat (integrins alpha-5-beta-1 and alpha-v-beta-3), suggesting Tat and IFN-gamma play major roles in AIDS-KS PubMed
    tat HIV-1 Tat induces angiogenesis and cooperates in the development of AIDS-associated Kaposi sarcoma as a result of interactions with integrins alpha-5-beta-1 and alpha-v-beta 3 PubMed
    tat Activation of primary T cells by HIV-1 Tat involves integrin receptors and monoclonal antibodies to integrin alpha 5 inhibit Tat-induced upregulation of CD25 PubMed
    tat The arginine-glycine-aspartic acid (RGD) sequence present at the carboxy-terminal of HIV-1 Tat mediates vascular cell and monocyte migration and invasion by binding to the alpha-5-beta-1 and alpha-v-beta-3 integrins PubMed
    Vpr vpr HIV-1 Vpr-expressing Jurkat T cell clones showed upregulated expression of integrin alpha 5, suggesting a role of Vpr in modulating the cell adhesion process PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002196.1 NP_002202.2 ITGB1    BIND  PubMed VLA5-alpha5 interacts with VLA5-beta. 
    P08648 Q15389 ANGPT1    HPRD  PubMed  
    P08648 Q9Y5C1 ANGPTL3    HPRD  PubMed  
    P08648 Q13017 ARHGAP5    HPRD  PubMed  
    P08648 Q9Y679 AUP1    HPRD  PubMed  
    P08648 P21926 CD9    HPRD  PubMed  
    P08648 P39060 COL18A1    HPRD  PubMed  
    P08648 P02452 COL1A1    HPRD  PubMed  
    P08648 P00533 EGFR    HPRD  PubMed  
    P08648 P04626 ERBB2    HPRD  PubMed  
    P08648 P21802 FGFR2    HPRD  PubMed  
    P08648 P35916 FLT4    HPRD  PubMed  
    P08648 P02751 FN1    HPRD  PubMed  
    P08648 O14908 GIPC1    HPRD  PubMed  
    P08648 P05556 ITGB1    HPRD  PubMed  
    P08648 P05106 ITGB3    HPRD  PubMed  
    P08648 P18084 ITGB5    HPRD  PubMed  
    P08648 P32004 L1CAM    HPRD  PubMed  
    P08648 Nischarin NISCH    HPRD  PubMed  
    P08648 P16284 PECAM1    HPRD  PubMed  
    P08648 P10451 SPP1    HPRD  PubMed  
    P08648 P24821 TNC    HPRD  PubMed  
    BioGRID:109884 BioGRID:107031 AUP1    BioGRID  PubMed Two-hybrid 
    BioGRID:109884 BioGRID:107262 CALR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109884 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109884 BioGRID:107366 CD9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109884 BioGRID:108554 FGFR2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109884 BioGRID:108621 FN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109884 BioGRID:115978 GIPC1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109884 BioGRID:109824 ILK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109884 BioGRID:109894 ITGB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109884 BioGRID:110094 L1CAM    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109884 BioGRID:111368 PLP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109884 BioGRID:111815 RABIF    BioGRID  PubMed Two-hybrid 
    BioGRID:109884 BioGRID:112574 SPP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109884 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
      Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem
      Angiopoietin receptor Tie2-mediated signaling
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
      Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Dilated cardiomyopathy, conserved biosystem (from KEGG)
      Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
    • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Shigellosis, organism-specific biosystem (from KEGG)
      Shigellosis, organism-specific biosystemShigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestina...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signal transduction by L1, organism-specific biosystem (from REACTOME)
      Signal transduction by L1, organism-specific biosystemBesides adhesive roles in cell cell interaction, L1 functions as a signal transducing receptor providing neurons with cues from their environment for axonal growth and guidance. L1 associates with be...
    • Signaling events mediated by focal adhesion kinase, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by focal adhesion kinase, organism-specific biosystem
      Signaling events mediated by focal adhesion kinase
    • Syndecan-2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-2-mediated signaling events, organism-specific biosystem
      Syndecan-2-mediated signaling events
    • Syndecan-4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-4-mediated signaling events, organism-specific biosystem
      Syndecan-4-mediated signaling events
    • VEGFR3 signaling in lymphatic endothelium, organism-specific biosystem (from Pathway Interaction Database)
      VEGFR3 signaling in lymphatic endothelium, organism-specific biosystem
      VEGFR3 signaling in lymphatic endothelium

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    integrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    platelet-derived growth factor receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    vascular endothelial growth factor receptor 2 binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    angiogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    axon guidance TAS
    Traceable Author Statement
    more info
    		  
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell-cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell-substrate junction assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    heterophilic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    leukocyte cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    leukocyte migration TAS
    Traceable Author Statement
    more info
    		  
    memory IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of vascular endothelial growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    wound healing, spreading of epidermal cells IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    alphav-beta3 integrin-vitronectin complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    colocalizes_with cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    ruffle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    colocalizes_with ruffle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    synaptosome IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    integrin alpha-5
    Names
    integrin alpha-5
    VLA-5
    integrin alpha-F
    CD49 antigen-like family member E
    fibronectin receptor subunit alpha
    fibronectin receptor, alpha subunit
    very late activation protein 5, alpha subunit
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002205.2 → NP_002196.2  integrin alpha-5 precursor

      Status: REVIEWED

      Source sequence(s)
      BC008786, BM787112, BX647780
      Consensus CDS
      CCDS8880.1
      UniProtKB/Swiss-Prot
      P08648
      Related
      ENSP00000293379, OTTHUMP00000242260, ENST00000293379, OTTHUMT00000406174
      Conserved Domains (2) summary
      pfam08441
      Location:490 – 921
      Blast Score: 1057
      Integrin_alpha2; Integrin alpha
      cl15299
      Location:389 – 422
      Blast Score: 122
      FG-GAP; FG-GAP repeat

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      54789045..54813050, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      51828142..51852148, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC079313.35 (27438..51443) None
    genomic CH471054.1 EAW96780.1
      EAW96781.1
      EAW96782.1
    genomic HI574152.1 CBX47565.1
    mRNA AK291570.1 BAF84259.1
    mRNA AK304696.1 BAG65466.1
    mRNA AK311051.1 None
    mRNA AK312414.1 BAG35324.1
    mRNA AU133210.1 None
    mRNA AY429549.1 None
    mRNA BC008786.2 AAH08786.1
    mRNA BM787112.1 None
    mRNA BX647780.1 None
    mRNA M13918.2 AAA52467.1
    mRNA X06256.1 CAA29601.1
    other-genetic DQ892690.2 ABM83616.1
    other-genetic EU176722.1 ABW03523.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08648.2 GenPept UniProtKB/Swiss-Prot:P08648
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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