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    ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) [ Homo sapiens ]

    Gene ID: 3676, updated on 19-May-2012
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    Summary

    Official Symbol
    ITGA4provided by HGNC
    Official Full Name
    integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)provided by HGNC
    Primary source
    HGNC:6140
    See related
    Ensembl:ENSG00000115232; HPRD:01894; MIM:192975; Vega:OTTHUMG00000154212
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IA4; CD49D; MGC90518
    Summary
    The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    2q31.3
    Sequence :
    Chromosome: 2; NC_000002.11 (182321619..182402474)
    See ITGA4 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2E 3 Neighboring gene microRNA 4437 Neighboring gene ceramide kinase-like Neighboring gene Sin3A-associated protein, 18kDa pseudogene Neighboring gene neuronal differentiation 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Acquisition of resistance toward HYD1 correlates with a reduction in cleaved α4 integrin expression and a compromised CAM-DR phenotype. Emmons MF, et al. Mol Cancer Ther, 2011 Dec. PMID 21980133.
    2. Dynamic alterations in integrin α4 expression by hypoxia are involved in trophoblast invasion during early implantation. Na KH, et al. J Cell Biochem, 2012 Feb. PMID 21976114.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells. Brachtl G, et al. PLoS One, 2011. PMID 21876768.
    5. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. Okada Y, et al. PLoS Genet, 2011 Jun. PMID 21738478.

    See all (160) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. HYD1 is more potent in relapsed myeloma specimens than newly diagnosed patients, a finding that correlated with alpha4 integrin expression.
      Title: Acquisition of resistance toward HYD1 correlates with a reduction in cleaved α4 integrin expression and a compromised CAM-DR phenotype.
    2. dynamic changes in integrins, including those in integrin alpha 4 expression by hypoxia, play a regulatory role in trophoblast invasion
      Title: Dynamic alterations in integrin α4 expression by hypoxia are involved in trophoblast invasion during early implantation.
    3. These data argue for a prominent role of VLA-4 but not CD38 expression in the homing of chronic lymphocytic leukemia cells to bone marrow (BM) niches and in human BM infiltration.
      Title: Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells.
    4. Data show that the expression of CD49d is strongly associated with expression of the chemokine receptor CXCR4 suggesting a co-ordinated role for these molecules in the trafficking of CLL cells to the lymphoid tissues.
      Title: CD49d is an independent prognostic marker that is associated with CXCR4 expression in CLL.
    5. alpha4 integrin-mediated adhesion is upregulated during T lymphocyte extravasation by activating Galpha subunit-dependent inside-out signaling.
      Title: RGS10 restricts upregulation by chemokines of T cell adhesion mediated by α4β1 and αLβ2 integrins.
    6. expression of VLA-4 in PBMC of hemorrhagic fever with renal syndrome (HFRS) patients at different stages were higher than normal controls, except recovery stage; VLA-4 might play an important role in the immunopathological lesions of HFRS
      Title: Expression of VLA-4 molecule in PBMC from patients with hemorrhagic fever with renal syndrome.
    7. expression pattern of very late antigen-4 integrin was studied by fluorescence-activated cell sorting and Western blotting experiments, and cell adhesion was analyzed by fluorometric adhesion assay
      Title: Toll-like receptor-9 triggering modulates expression of α-4 integrin on human B lymphocytes and their adhesion to extracellular matrix proteins.
    8. An association between the cytoplasmic tail of alpha 4 integrin and non-muscle myosin IIA (MIIA)was demonstrated by co-immunoprecipitation.
      Title: Association between α4 integrin cytoplasmic tail and non-muscle myosin IIA regulates cell migration.
    9. findings indicate that alpha4beta7*IgG can be used as a probe for functional MAdCAM-1 expressed on HEVs in GALT and could potentially serve as an anti-inflammatory drug inhibiting GALT-specific lymphocyte migration
      Title: An integrin alpha4beta7•IgG heterodimeric chimera binds to MAdCAM-1 on high endothelial venules in gut-associated lymphoid tissue.
    10. Findings suggest that the inactive alpha4beta7 and alpha4beta7 activated by different stimuli have distinct conformations with different structural requirements for MAdCAM-1 binding.
      Title: The CC' and DE loops in Ig domains 1 and 2 of MAdCAM-1 play different roles in MAdCAM-1 binding to low- and high-affinity integrin alpha4beta7.
    Submit: New GeneRIF Correction See all (112)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Identification of nine novel Loci associated with white blood cell subtypes in a Japanese population.

    Multiple common variants for celiac disease influencing immune gene expression.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_000876.1 AAC68675.1 EED    BIND  PubMed Integrin alpha-4 interacts with WAIT-1. 
    NP_000876.1 NP_002202.2 ITGB1    BIND  PubMed VLA4-alpha4 interacts with VLA4-beta. 
    NP_000876.1 NP_000880.1 ITGB7    BIND  PubMed Integrin-alpha4 interacts with Integrin-beta7. 
    NP_000876.1 NP_004802.1 LPXN    BIND  PubMed Leupaxin (LPXN) interacts with integrin alpha-4 (ITGA4). 
    NP_000876.1 NP_002850.1 PXN    BIND  PubMed Paxillin (PXN) interacts with integrin alpha-4 (ITGA4). 
    NP_000876.1 NP_057011.2 TGFB1I1    BIND  PubMed TGFB1I1 (Hic-5) interacts with integrin alpha-4 (ITGA4). 
    P13612 Q9UKQ2 ADAM28    HPRD  PubMed  
    P13612 P60033 CD81    HPRD  PubMed  
    P13612 P27701 CD82    HPRD  PubMed  
    P13612 Embryonic ectoderm development EED    HPRD  PubMed  
    P13612 P02751 FN1    HPRD  PubMed  
    P13612 Q14773 ICAM4    HPRD  PubMed  
    P13612 P13612 ITGA4    HPRD  PubMed  
    P13612 P05556 ITGB1    HPRD  PubMed  
    P13612 P26010 ITGB7    HPRD  PubMed  
    P13612 O00214 LGALS8    HPRD  PubMed  
    P13612 O60711 LPXN    HPRD  PubMed  
    P13612 Q13477 MADCAM1    HPRD  PubMed  
    P13612 P17612 PRKACA    HPRD  PubMed  
    P13612 P10644 PRKAR1A    HPRD  PubMed  
    P13612 P49023 PXN    HPRD  PubMed  
    P13612 HIC5 TGFB1I1    HPRD  PubMed  
    P13612 P13611 VCAN    HPRD  PubMed  
    BioGRID:109883 BioGRID:107413 CD81    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109883 BioGRID:114265 EED    BioGRID  PubMed Two-hybrid 
    BioGRID:109883 BioGRID:110155 LGALS8    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109883 BioGRID:111719 PTK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109883 BioGRID:111787 PXN    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109883 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
      Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Dilated cardiomyopathy, conserved biosystem (from KEGG)
      Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
    • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
      Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
    • Intestinal immune network for IgA production, conserved biosystem (from KEGG)
      Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Paxillin-dependent events mediated by a4b1, organism-specific biosystem (from Pathway Interaction Database)
      Paxillin-dependent events mediated by a4b1, organism-specific biosystem
      Paxillin-dependent events mediated by a4b1
    • Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem (from Pathway Interaction Database)
      Paxillin-independent events mediated by a4b1 and a4b7, organism-specific biosystem
      Paxillin-independent events mediated by a4b1 and a4b7
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • a4b1 and a4b7 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
      a4b1 and a4b7 Integrin signaling, organism-specific biosystem
      a4b1 and a4b7 Integrin signaling

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    fibronectin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    B cell differentiation IC
    Inferred by Curator
    more info
    		 PubMed 
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    blood vessel remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    chorio-allantoic fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    face development IEA
    Inferred from Electronic Annotation
    more info
    		  
    heart development IEA
    Inferred from Electronic Annotation
    more info
    		  
    heterophilic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    leukocyte cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
    		  
    regulation of immune response TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    integrin alpha-4
    Names
    integrin alpha-4
    269C wild type
    integrin alpha 4
    integrin alpha-IV
    VLA-4 subunit alpha
    integrin alpha-4 subunit
    CD49 antigen-like family member D
    antigen CD49D, alpha-4 subunit of VLA-4 receptor
    very late activation protein 4 receptor, alpha 4 subunit
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000885.4 → NP_000876.3  integrin alpha-4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC020595, X16983
      Consensus CDS
      CCDS42788.1
      UniProtKB/Swiss-Prot
      P13612
      Related
      ENSP00000380227, OTTHUMP00000205320, ENST00000397033, OTTHUMT00000334427
      Conserved Domains (3) summary
      pfam08441
      Location:463 – 902
      Blast Score: 885
      Integrin_alpha2; Integrin alpha
      pfam13517
      Location:314 – 388
      Blast Score: 118
      VCBS; Family description
      cl15299
      Location:366 – 418
      Blast Score: 164
      FG-GAP; FG-GAP repeat

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      182321619..182402474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      174178675..174259339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC020595.7 (66169..147024) None
    genomic CH471058.2 EAX10985.1
      EAX10986.1
      EAX10987.1
    mRNA AB208885.1 BAD92122.1
    mRNA AJ504733.1 CAD43289.1
    mRNA AJ508356.1 CAD48165.1
    mRNA AJ510246.1 CAD53326.1
    mRNA AJ510247.1 CAD53327.1
    mRNA AJ510248.1 CAD53328.1
    mRNA AJ510249.1 CAD53329.1
    mRNA AK303220.1 BAG64307.1
    mRNA AK303478.1 BAG64514.1
    mRNA AK310610.1 None
    mRNA AK311738.1 None
    mRNA BC016671.2 AAH16671.1
    mRNA BC055419.1 AAH55419.1
    mRNA BC080190.1 AAH80190.1
    mRNA L12002.1 AAB59613.1
    mRNA X16983.1 CAA34852.1
    other-genetic BC146277.1 AAI46278.1
    other-genetic BC156712.1 AAI56713.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAB25486.1 GenPept
    P13612.3 GenPept UniProtKB/Swiss-Prot:P13612
    Q13682 GenPept UniProtKB/TrEMBL:Q13682
    Q59H74 GenPept UniProtKB/TrEMBL:Q59H74
    Q68EM9 GenPept UniProtKB/TrEMBL:Q68EM9
    Q6PJE7 GenPept UniProtKB/TrEMBL:Q6PJE7
    Q7Z4L6 GenPept UniProtKB/TrEMBL:Q7Z4L6
    Q8IU66 GenPept UniProtKB/TrEMBL:Q8IU66
    Q8IU71 GenPept UniProtKB/TrEMBL:Q8IU71
    Q8IUA2 GenPept UniProtKB/TrEMBL:Q8IUA2
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
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