My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) [ Homo sapiens ]

    Gene ID: 3673, updated on 19-May-2012
    Help top of page

    Summary

    Official Symbol
    ITGA2provided by HGNC
    Official Full Name
    integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)provided by HGNC
    Primary source
    HGNC:6137
    See related
    Ensembl:ENSG00000164171; HPRD:01893; MIM:192974; Vega:OTTHUMG00000131165
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BR; GPIa; CD49B; VLA-2; VLAA2; BDPLT9
    Summary
    This gene product belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
    Help top of page

    Genomic context

    Location :
    5q11.2
    Sequence :
    Chromosome: 5; NC_000005.9 (52285156..52390609)
    See ITGA2 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene integrin, alpha 1 Neighboring gene pelota homolog (Drosophila) Neighboring gene ribosomal protein L17 pseudogene 21 Neighboring gene uncharacterized LOC257396 Neighboring gene molybdenum cofactor synthesis 2

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. [Expressions of integrinalpha2beta1 and CD133 in benign prostatic hyperplasia complicated by prostatitis and their significance]. Ding Q, et al. Zhonghua Nan Ke Xue, 2011 Oct. PMID 22049795.
    2. Mean platelet volume and integrin alleles correlate with levels of integrins α(IIb)β(3) and α(2)β(1) in acute coronary syndrome patients and normal subjects. Kunicki TJ, et al. Arterioscler Thromb Vasc Biol, 2012 Jan. PMID 22015659.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. SPARC promotes cathepsin B-mediated melanoma invasiveness through a collagen I/α2β1 integrin axis. Girotti MR, et al. J Invest Dermatol, 2011 Dec. PMID 21850018.
    5. Integrins α2β1 and α11β1 regulate the survival of mesenchymal stem cells on collagen I. Popov C, et al. Cell Death Dis, 2011 Jul 28. PMID 21796158.

    See all (309) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Expression of laminin beta1 and integrin alpha2 is elevated in the anterior temporal neocortex tissue from patients with intractable epilepsy.
      Title: Expression of laminin β1 and integrin α2 in the anterior temporal neocortex tissue of patients with intractable epilepsy.
    2. Inflammation can up-regulate the expressions of Integrin alpha2beta1 and CD133 in benign prostatic hyperplasia tissue.
      Title: [Expressions of integrinalpha2beta1 and CD133 in benign prostatic hyperplasia complicated by prostatitis and their significance].
    3. Under convertase inhibition, alpha2beta1 engagement led to enhanced phosphorylation of both FAK (focal adhesion kinase) and MAPK (mitogen-activated protein kinase).
      Title: αv integrin processing interferes with the cross-talk between αvβ5/β6 and α2β1 integrins.
    4. Findings do not support the influence of the IRGA2807T allele in the development of retinopathy in type 2 diabetes.
      Title: No association between the ITGA2 807T allele and retinopathy in french patients with type 2 diabetes.
    5. Platelet alphaIIbeta3 and alpha2beta1 levels were measured by flow cytometry in 320 acute coronary syndrome patients and 128 normal subjects and compared with MPV, platelet count, ITGA2 rs1126643, and ITGB3 rs5918 alleles.
      Title: Mean platelet volume and integrin alleles correlate with levels of integrins α(IIb)β(3) and α(2)β(1) in acute coronary syndrome patients and normal subjects.
    6. Analysis of the data led to the elucidation of a new molecular mechanism by which SPARC promotes cathepsin B-mediated melanoma invasiveness using collagen I and alpha2beta1 integrins as mediators.
      Title: SPARC promotes cathepsin B-mediated melanoma invasiveness through a collagen I/α2β1 integrin axis.
    7. CDKN2A, GATA3, CREBBP, ITGA2, NBL1 and TGM4 were down-regulated in the prostate carcinoma glands compared to the corresponding normal glands
      Title: Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers.
    8. The disturbance of alpha2beta1 mediated interactions to collagen I results in a tremendous reduction of hMSC numbers owing to mitochondrial leakage accompanied by Bcl-2-associated X protein upregulation.
      Title: Integrins α2β1 and α11β1 regulate the survival of mesenchymal stem cells on collagen I.
    9. Blocking the alpha(2)beta(1) receptor on human mesenchymal stem cells also resulted in a reduction of cell adhesion on both types of collagen-like peptide surfaces.
      Title: Integrin-mediated adhesion and proliferation of human MSCs elicited by a hydroxyproline-lacking, collagen-like peptide.
    10. A vicinal thiol-containing population of alphaIIbbeta3 provides redox sensitive sites for regulation of alphaIIbbeta3.
      Title: Vicinal thiols are required for activation of the αIIbβ3 platelet integrin.
    Submit: New GeneRIF Correction See all (157)
    Help top of page

    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Neonatal alloimmune thrombocytopenia

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002194.1 NP_002202.2 ITGB1    BIND  PubMed VLA2-alpha2 interacts with VLA2-beta. 
    P17301 P68133 ACTA1    HPRD  PubMed  
    P17301 Q9Y679 AUP1    HPRD  PubMed  
    P17301 P21926 CD9    HPRD  PubMed  
    P17301 P02452 COL1A1    HPRD  PubMed  
    P17301 P08123 COL1A2    HPRD  PubMed  
    P17301 P27658 COL8A1    HPRD  PubMed  
    P17301 P98160 HSPG2    HPRD  PubMed  
    P17301 P17301 ITGA2    HPRD  PubMed  
    P17301 P05556 ITGB1    HPRD  PubMed  
    P17301 P25391 LAMA1    HPRD  PubMed  
    P17301 P03956 MMP1    HPRD  PubMed  
    BioGRID:109880 BioGRID:107031 AUP1    BioGRID  PubMed Two-hybrid 
    BioGRID:109880 BioGRID:110346 CD46    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109880 BioGRID:107674 COL1A1    BioGRID  PubMed Co-purification 
    BioGRID:109880 BioGRID:129792 LAMA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109880 BioGRID:110456 MMP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109880 BioGRID:111815 RABIF    BioGRID  PubMed Two-hybrid 
    BioGRID:109880 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Arf6 trafficking events, organism-specific biosystem (from Pathway Interaction Database)
      Arf6 trafficking events, organism-specific biosystem
      Arf6 trafficking events
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • CHL1 interactions, organism-specific biosystem (from REACTOME)
      CHL1 interactions, organism-specific biosystemClose homolog of L1 (CHL1) is a member of the L1 family of cell adhesion molecules expressed by subpopulations of neurons and glia in the central and peripheral nervous system. CHL1 like L1 promotes ...
    • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR4-mediated signaling events, organism-specific biosystem
      CXCR4-mediated signaling events
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
      Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Dilated cardiomyopathy, conserved biosystem (from KEGG)
      Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
    • Integrin-mediated cell adhesion, organism-specific biosystem (from WikiPathways)
      Integrin-mediated cell adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Platelet Adhesion to exposed collagen, organism-specific biosystem (from REACTOME)
      Platelet Adhesion to exposed collagen, organism-specific biosystemInitiation of platelet adhesion is the first step in the formation of the platelet plug. Circulating platelets are arrested and subsequently activated by exposed collagen and vWF. Several collagen bi...
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Syndecan-2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-2-mediated signaling events, organism-specific biosystem
      Syndecan-2-mediated signaling events
    • VEGFR3 signaling in lymphatic endothelium, organism-specific biosystem (from Pathway Interaction Database)
      VEGFR3 signaling in lymphatic endothelium, organism-specific biosystem
      VEGFR3 signaling in lymphatic endothelium

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    collagen binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    axon guidance TAS
    Traceable Author Statement
    more info
    		  
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell-matrix adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    organ morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    basal part of cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell surface IDA
    Inferred from Direct Assay
    more info
    		  
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    integrin alpha-2
    Names
    integrin alpha-2
    integrin alpha 2
    collagen receptor
    VLA-2 subunit alpha
    platelet antigen Br
    platelet glycoprotein Ia
    platelet glycoprotein GPIa
    CD49 antigen-like family member B
    platelet membrane glycoprotein Ia
    very late activation protein 2 receptor, alpha-2 subunit
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008330.1 RefSeqGene

      Range
      5001..110454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002203.3 → NP_002194.2  integrin alpha-2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC008966, AU126174, BE048389, BF355124, BG288116, BG494837, BG771368, BM828183, BM979113, BP280760, BP381403, CA442768, CK904145, CN272390, DA343078, DA545055, X17033
      Consensus CDS
      CCDS3957.1
      UniProtKB/Swiss-Prot
      P17301
      Related
      ENSP00000296585, OTTHUMP00000161816, ENST00000296585, OTTHUMT00000253857
      Conserved Domains (4) summary
      cd01469
      Location:173 – 353
      Blast Score: 564
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam08441
      Location:649 – 1060
      Blast Score: 715
      Integrin_alpha2; Integrin alpha
      pfam13517
      Location:563 – 636
      Blast Score: 88
      VCBS; Family description
      cl15299
      Location:551 – 604
      Blast Score: 159
      FG-GAP; FG-GAP repeat

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      52285156..52390609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      49257212..49362658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC008966.9 (50606..153539) None
    genomic AF035968.2 AAC94975.1
    genomic AF062039.1 AAF77577.1
    genomic AF512556.1 AAM34795.1
    genomic CH471123.1 EAW54872.1
      EAW54873.1
    genomic JA738693.1 CCF76999.1
    genomic L24121.1 AAA16619.2
    genomic S72155.1 AAD14096.1
    mRNA AK307952.1 None
    mRNA AU126174.1 None
    mRNA BC143505.1 None
    mRNA BC143508.1 None
    mRNA BC143509.1 None
    mRNA BC143511.1 None
    mRNA BC143512.1 None
    mRNA BE048389.1 None
    mRNA BF355124.1 None
    mRNA BG288116.1 None
    mRNA BG494837.1 None
    mRNA BG771368.1 None
    mRNA BM828183.1 None
    mRNA BM979113.1 None
    mRNA BP280760.1 None
    mRNA BP381403.1 None
    mRNA CA442768.1 None
    mRNA CK904145.1 None
    mRNA CN272390.1 None
    mRNA DA343078.1 None
    mRNA DA545055.1 None
    mRNA X17033.1 CAA34894.1
    other-genetic BC148596.1 AAI48597.1
    other-genetic BC156715.1 AAI56716.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17301.1 GenPept UniProtKB/Swiss-Prot:P17301
    Q16183 GenPept UniProtKB/TrEMBL:Q16183
    Q71V33 GenPept UniProtKB/TrEMBL:Q71V33
    Q9NNZ2 GenPept UniProtKB/TrEMBL:Q9NNZ2
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...