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    Cdk5 Cyclin-dependent kinase 5 [ Drosophila melanogaster ]

    Gene ID: 36727, updated on 10-May-2012
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    Summary

    Official Symbol
    Cdk5provided by Flybase
    Official Full Name
    Cyclin-dependent kinase 5provided by Flybase
    Primary source
    FLYBASE:FBgn0013762
    Locus tag
    Dmel_CG8203
    Gene type
    protein coding
    RNA name
    Cyclin-dependent kinase 5
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cdk5; CDK5; CG8203; DmCdk5; Dmel\CG8203
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    Genomic context

    Location :
    52A13-52A13
    Sequence :
    Chromosome: 2R; NT_033778.3 (11457035..11458918, complement)
    See Cdk5 in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene CG8195 gene product from transcript CG8195-RA Neighboring gene flotillin Neighboring gene CG30466 gene product from transcript CG30466-RA Neighboring gene CG8204 gene product from transcript CG8204-RA Neighboring gene CG42524 gene product from transcript CG42524-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Cdk5 regulates the size of an axon initial segment-like compartment in mushroom body neurons of the Drosophila central brain. Trunova S, et al. J Neurosci, 2011 Jul 20. PMID 21775591.
    2. Drosophila cdk5 is needed for locomotive behavior and NMJ elaboration, but seems dispensable for synaptic transmission. Kissler AE, et al. Dev Neurobiol, 2009 May. PMID 19263480.
    3. Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model. Chatterjee S, et al. Hum Mol Genet, 2009 Jan 1. PMID 18930955.
    4. Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways. Haussmann IU, et al. Genome Biol, 2008 Apr 17. PMID 18419806.
    5. Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1. Choe EA, et al. J Neurosci, 2007 Aug 29. PMID 17728463.

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The data of this study demonstrated that Cdk5/p35 kinase is a key regulator of the development and maintenance of the axon initial segment in Drosophila.
      Title: Cdk5 regulates the size of an axon initial segment-like compartment in mushroom body neurons of the Drosophila central brain.
    2. In Drosophila the cdk5 is needed for locomotive behavior and NMJ elaboration.
      Title: Drosophila cdk5 is needed for locomotive behavior and NMJ elaboration, but seems dispensable for synaptic transmission.
    3. Cdk5/p35 did not have major effects on tau toxicity or phosphorylation.
      Title: Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model.
    4. Therefore, we propose that Abl and p35/p25 cooperate in promoting Cdk5-pY15, which deregulates Cdk5 activity and subcellular localization in Abeta42-triggered neurodegeneration.
      Title: Abl deregulates Cdk5 kinase activity and subcellular localization in Drosophila neurodegeneration.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_477080.1 NP_523355.1 CycD    BIND  PubMed Cdk5 interacts with CycD (Cdi3). 
    BioGRID:62461 BioGRID:63211 CG13510    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:63320 CG13558    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:63648 CG13900    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:59406 CG14619    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:62914 CG15124    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:63558 CG15861    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:72486 CG17508    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:58197 CG2256    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:58525 CG2371    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:57754 CG2865    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:76940 CG31204    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:59632 CG31679    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:61742 CG34350    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:68004 CG4673    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:65539 CG4858    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:62713 CG5009    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:64118 CG5568    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:60452 CG5708    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:60446 CG5731    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:62268 CG6191    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:60628 CG6488    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:63816 CG8993    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:60471 Cdk5alpha    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:62461 BioGRID:58885 Chc    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:66526 Csk    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:66871 CycC    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:58898 CycD    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:60939 CycE    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:63921 CycJ    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:66030 Dfd    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:63542 Dll    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:69651 E5    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:61444 EcR    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:59912 His3.3A    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:63381 PHDP    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:60212 TwdlE    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:57745 crn    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:62866 ena    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:68607 pan    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:65883 rev7    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:66236 skap    BioGRID  PubMed Two-hybrid 
    BioGRID:62461 BioGRID:68433 spn-A    BioGRID  PubMed Two-hybrid 
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    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    cyclin binding NAS
    Non-traceable Author Statement
    more info
    		  
    cyclin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cyclin-dependent protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    motor axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		  
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cyclin-dependent protein kinase 5 holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG8203 gene product from transcript CG8203-RA
    Names
    CG8203-PA
    Cdk5-PA
    Cyclin-dependent kinase 5
    NP_477080.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      11457035..11458918, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057732.3 → NP_477080.1  Cyclin-dependent kinase 5 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48609
      Related
      FBpp0086483, FBtr0087350
      Conserved Domains (2) summary
      cd07839
      Location:3 – 286
      Blast Score: 1553
      STKc_CDK5; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5
      PLN00009
      Location:1 – 288
      Blast Score: 1021
      PLN00009; cyclin-dependent kinase A; Provisional
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE013599.4 AAF58119.1
    mRNA AY061049.1 AAL28597.1
    mRNA X99511.1 CAA67861.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48609.2 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

      Supplemental Content