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    AR androgen receptor [ Homo sapiens (human) ]

    Gene ID: 367, updated on 14-May-2013
    Official Symbol
    ARprovided by HGNC
    Official Full Name
    androgen receptorprovided by HGNC
    Primary source
    HGNC:644
    Locus tag
    RP11-383C12.1
    See related
    Ensembl:ENSG00000169083; HPRD:02437; MIM:313700; Vega:OTTHUMG00000021740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KD; AIS; TFM; DHTR; SBMA; HYSP1; NR3C4; SMAX1; HUMARA
    Summary
    The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
    Location :
    Xq12
    Sequence :
    Chromosome: X; NC_000023.10 (66763874..66950461)
    See AR in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 681 pseudogene Neighboring gene poly(A) binding protein, nuclear 1 pseudogene Neighboring gene BMI1 polycomb ring finger oncogene pseudogene Neighboring gene oligophrenin 1 Neighboring gene phosphoglycerate kinase 1, pseudogene 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Androgen receptor CAG repeat length is associated with body fat and serum SHBG in boys: a prospective cohort study. Mouritsen A, et al. J Clin Endocrinol Metab, 2013 Mar. PMID 23393169.
    2. Transcription factor KLLN inhibits tumor growth by AR suppression, induces apoptosis by TP53/TP73 stimulation in prostate carcinomas, and correlates with cellular differentiation. Wang Y, et al. J Clin Endocrinol Metab, 2013 Mar. PMID 23386643.
    3. Melanoma antigen-A11 (MAGE-A11) enhances transcriptional activity by linking androgen receptor dimers. Minges JT, et al. J Biol Chem, 2013 Jan 18. PMID 23172223.
    4. The CAG repeat polymorphism in the androgen receptor gene modifies the risk for hypospadias in Caucasians. Adamovic T, et al. BMC Med Genet, 2012 Nov 20. PMID 23167717.
    5. p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2). Liu T, et al. J Biol Chem, 2013 Feb 1. PMID 23132866.

    See all (1475) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. KLLN is a transcription factor directly regulating AR, TP53, and TP73 expression, with a role in prostate carcinogenesis.
      Title: Transcription factor KLLN inhibits tumor growth by AR suppression, induces apoptosis by TP53/TP73 stimulation in prostate carcinomas, and correlates with cellular differentiation.
    2. findings are indicative of the synergistic effect of AR(CAG)n and CYP19(TTTA)n polymorphisms on semen quality, confirming the significance of AR and CYP19 genes for spermatogenesis.
      Title: Semen quality is influenced by androgen receptor and aromatase gene synergism.
    3. Associations between AR (CAG)n and peripubertal fat accumulation and serum SHBG concentrations indicate that this genetic polymorphism may influence the androgen-dependent fine-tuning of metabolic and reproductive factors at a young age.
      Title: Androgen receptor CAG repeat length is associated with body fat and serum SHBG in boys: a prospective cohort study.
    4. case-control study comprising 651 TC cases and 313 controls in a Norwegian population was conducted for investigation of polymorphisms in the LHR, SRD5A and AR genes and their possible association with TC
      Title: Variations in testosterone pathway genes and susceptibility to testicular cancer in Norwegian men.
    5. androgen-deprivation induced a decrease in AR and PSMA levels in androgen-sensitive LNCaP cells, which may be associated with the development of more aggressive disease-state following androgen deprivation therapy.
      Title: Prolonged androgen deprivation leads to downregulation of androgen receptor and prostate-specific membrane antigen in prostate cancer cells.
    6. The AR-V1 or V7 transcript level does not predict recurrence in patients with high grade prostate cancer at indeterminate risk for progression. Grade 3 cancer in mixed grade tumors may differ from 100% grade 3 cancer, at least in AR-V1 expression.
      Title: Transcript levels of androgen receptor variant AR-V1 or AR-V7 do not predict recurrence in patients with prostate cancer at indeterminate risk for progression.
    7. The genomic and transcriptional cross talk between AR and ERalpha signaling in a luminal breast cancer cell line, was investigated.
      Title: Research resource: interplay between the genomic and transcriptional networks of androgen receptor and estrogen receptor α in luminal breast cancer cells.
    8. Androgen-mediated androgen receptor signals promote bladder carcinogenesis by down-regulating the expression of UDP-glucuronosyltransferases in the bladder.
      Title: Androgen receptor signals regulate UDP-glucuronosyltransferases in the urinary bladder: a potential mechanism of androgen-induced bladder carcinogenesis.
    9. Our findings do not support a role of the AR CAG repeat length in amyotrophic lateral sclerosis .
      Title: CAG repeat length in androgen receptor gene is not associated with amyotrophic lateral sclerosis.
    10. MAGE-A11 increases AR transcriptional activity by linking androgen receptor dimers.
      Title: Melanoma antigen-A11 (MAGE-A11) enhances transcriptional activity by linking androgen receptor dimers.
    Submit: New GeneRIF Correction See all (903)

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Androgen resistance syndrome

    Summary from GeneReviews: Androgen Insensitivity Syndrome Go to GeneReviews

    Disease Characteristics
    Androgen insensitivity syndrome (AIS) is typically characterized by evidence of feminization (i.e., undermasculinization) of the external genitalia at birth, abnormal secondary sexual development in puberty, and infertility in individuals with a 46,XY karyotype. AIS represents a spectrum of defects in androgen action and can be subdivided into three broad phenotypes: Complete androgen insensitivity syndrome (CAIS), with typical female external genitalia. Partial androgen insensitivity syndrome (PAIS) with predominantly female, predominantly male, or ambiguous external genitalia. Mild androgen insensitivity syndrome (MAIS) with typical male external genitalia.
    Diagnosis Testing
    The diagnosis of AIS in individuals with a 46,XY karyotype is based on the following clinical findings: undermasculinization of the external genitalia, impaired spermatogenesis with otherwise normal testes, absent or rudimentary mullerian structures, evidence of normal or increased synthesis of testosterone and its normal conversion to dihydrotestosterone, normal or increased luteinizing hormone (LH) production by the pituitary gland, and deficient or defective androgen binding activity of genital skin fibroblasts. Molecular genetic testing of AR, the only gene in which mutations are known to cause androgen insensitivity syndrome, is available clinically and can be used to confirm the diagnosis in some, but not all, instances.
    Genetic Counseling
    AIS is inherited in an X-linked manner. Affected 46,XY individuals are almost always infertile. Each offspring of a female known to be an AR mutation carrier (heterozygote) is at a 25% risk for each of the following: Having a 46,XY karyotype and being affected. Having a 46,XY karyotype and being unaffected. Having a 46,XX karyotype and being a carrier. Having a 46,XX karyotype and not being a carrier. Carrier testing for at-risk relatives and prenatal testing for pregnancies at increased risk are possible if the disease-causing mutation in the family is known.
    References

    Bulbo-spinal atrophy X-linked

    Summary from GeneReviews: Spinal and Bulbar Muscular Atrophy Go to GeneReviews

    Disease Characteristics
    Spinal and bulbar muscular atrophy (SBMA) is a gradually progressive neuromuscular disorder in which degeneration of lower motor neurons results in proximal muscle weakness, muscle atrophy, and fasciculations. SBMA occurs only in males. Affected individuals often show gynecomastia, testicular atrophy, and reduced fertility as a result of mild androgen insensitivity.
    Diagnosis Testing
    All males with SBMA have expansion of a CAG trinucleotide repeat (>35 CAGs) in the androgen receptor gene (AR). Molecular genetic testing for the CAG trinucleotide repeat expansion is available on a clinical basis.
    Genetic Counseling
    SBMA is inherited in an X-linked manner. Affected males who are fertile pass the disease-causing allele to each daughter. Carrier females have a 50% chance of transmitting the CAG trinucleotide repeat expansion to each child; males who inherit the mutation will be affected; females who inherit the mutation will be carriers and will not be affected. Carrier testing for at-risk female relatives and prenatal testing for pregnancies at increased risk are possible if the disease-causing mutation in the family is known.
    References
    Products Interactant Other Gene Complex Source Pubs Description
    NP_000035.2 NP_005154.1 AKT1    BIND  PubMed Akt phosphorylates AR. 
    NP_000035.2 NP_150634.1 CASP1    BIND  PubMed Androgen Receptor interacts with caspase 1. This interaction was modeled on a demonstrated interaction between human androgen receptor and caspase 1 from an unspecified species. 
    NP_000035.2 NP_004337.2 CASP3    BIND  PubMed Androgen Receptor interacts with caspase 3. This interaction was modeled on a demonstrated interaction between human androgen receptor and caspase 3 from an unspecified species. 
    NP_000035.2 NP_001218.1 CASP7    BIND  PubMed Androgen Receptor interacts with caspase 7. 
    NP_000035.2 NP_203519.1 CASP8    BIND  PubMed Androgen Receptor interacts with caspase 8. 
    NP_000035.2 NP_001744.2 CAV1    BIND  PubMed Caveolin-1 interacts with AR. 
    NP_000035.2 AF520763.1 FGF8    BIND  PubMed AR interacts with FGF8 promoter. 
    NP_000035.2 NT_011109.15 KLK2    BIND  PubMed AR interacts with p-KLK-2. 
    NP_000035.2 AF394907.1 KLK3    BIND  PubMed AR interacts with p-PSA. 
    NP_000035.2 NP_003734.3 NCOA1    BIND  PubMed SRC-1a interacts with AR. 
    NP_000035.2 NP_671756.1 NCOA1    BIND  PubMed SRC-1e interacts with AR. 
    NP_000035.2 NP_006531.1 NCOA2    BIND  PubMed GRIP1 interacts with AR. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human AR. 
    NP_000035.2 NP_000312.1 RB1    BIND  PubMed Rb interacts with AR. 
    NP_000035.2 NP_057011.2 TGFB1I1    BIND  PubMed The carboxy terminus of ARA55 interacts with the carboxy terminus AR to enhance transcriptional activity. 
    P10275 Q08117 AES    HPRD  PubMed  
    P10275 P35869 AHR    HPRD  PubMed  
    P10275 P31749 AKT1    HPRD  PubMed  
    P10275 Q9BQE5 APOL2    HPRD  PubMed  
    P10275 Q92624 APPBP2    HPRD  PubMed  
    P10275 P10275 AR    HPRD  PubMed  
    P10275 P15336 ATF2    HPRD  PubMed  
    P10275 Q99933 BAG1    HPRD  PubMed  
    P10275 P38398 BRCA1    HPRD  PubMed  
    P10275 Calmodulin 1 CALM1    HPRD  PubMed  
    P10275 P27797 CALR    HPRD  PubMed  
    P10275 P29466 CASP1    HPRD  PubMed  
    P10275 P42574 CASP3    HPRD  PubMed  
    P10275 P55210 CASP7    HPRD  PubMed  
    P10275 Q14790 CASP8    HPRD  PubMed  
    P10275 Q03135 CAV1    HPRD  PubMed  
    P10275 P24385 CCND1    HPRD  PubMed  
    P10275 P24864 CCNE1    HPRD  PubMed  
    P10275 P51946 CCNH    HPRD  PubMed  
    P10275 P30304 CDC25A    HPRD  PubMed  
    P10275 P30305 CDC25B    HPRD  PubMed  
    P10275 Q16543 CDC37    HPRD  PubMed  
    P10275 P06493 CDK1    HPRD  PubMed  
    P10275 Q00534 CDK6    HPRD  PubMed  
    P10275 P50613 CDK7    HPRD  PubMed  
    P10275 P50750 CDK9    HPRD  PubMed  
    P10275 P10606 COX5B    HPRD  PubMed  
    P10275 Q92793 CREBBP    HPRD  PubMed  
    P10275 O14595 CTDSP2    HPRD  PubMed  
    P10275 P35222 CTNNB1    HPRD  PubMed  
    P10275 Q13620 CUL4B    HPRD  PubMed  
    P10275 P51398 DAP3    HPRD  PubMed  
    P10275 Q9UER7 DAXX    HPRD  PubMed  
    P10275 IQ motif and WD repeats 1 DCAF6    HPRD  PubMed  
    P10275 P20711 DDC    HPRD  PubMed  
    P10275 CAP binding protein complex interacting protein 1 EFCAB6    HPRD  PubMed  
    P10275 P00533 EGFR    HPRD  PubMed  
    P10275 Q09472 EP300    HPRD  PubMed  
    P10275 P03372 ESR1    HPRD  PubMed  
    P10275 P41161 ETV5    HPRD  PubMed  
    P10275 Q14192 FHL2    HPRD  PubMed  
    P10275 P21333 FLNA    HPRD  PubMed  
    P10275 P55317 FOXA1    HPRD  PubMed  
    P10275 Q12778 FOXO1    HPRD  PubMed  
    P10275 O14976 GAK    HPRD  PubMed  
    P10275 P04406 GAPDH    HPRD  PubMed  
    P10275 P63244 GNB2L1    HPRD  PubMed  
    P10275 Q9Y3R0 GRIP1    HPRD  PubMed  
    P10275 P49841 GSK3B    HPRD  PubMed  
    P10275 P06396 GSN    HPRD  PubMed  
    P10275 P35269 GTF2F1    HPRD  PubMed  
    P10275 P13984 GTF2F2    HPRD  PubMed  
    P10275 P32780 GTF2H1    HPRD  PubMed  
    P10275 Q13547 HDAC1    HPRD  PubMed  
    P10275 Q16665 HIF1A    HPRD  PubMed  
    P10275 Q9H422 HIPK3    HPRD  PubMed  
    P10275 P09429 HMGB1    HPRD  PubMed  
    P10275 P07900 HSP90AA1    HPRD  PubMed  
    P10275 P41252 IARS    HPRD  PubMed  
    P10275 P14735 IDE    HPRD  PubMed  
    P10275 Q16666 IFI16    HPRD  PubMed  
    P10275 P40189 IL6ST    HPRD  PubMed  
    P10275 Q15652 JMJD1C    HPRD  PubMed  
    P10275 P05412 JUN    HPRD  PubMed  
    P10275 Q92831 KAT2B    HPRD  PubMed  
    P10275 Q92993 KAT5    HPRD  PubMed  
    P10275 O95251 KAT7    HPRD  PubMed  
    P10275 O60341 KDM1A    HPRD  PubMed  
    P10275 Q12756 KIF1A    HPRD  PubMed  
    P10275 P20151 KLK2    HPRD  PubMed  
    P10275 P28482 MAPK1    HPRD  PubMed  
    P10275 Q00987 MDM2    HPRD  PubMed  
    P10275 Q15648 MED1    HPRD  PubMed  
    P10275 O60244 MED14    HPRD  PubMed  
    P10275 Q9BQG0 MYBBP1A    HPRD  PubMed  
    P10275 Q15788 NCOA1    HPRD  PubMed  
    P10275 Q15596 NCOA2    HPRD  PubMed  
    P10275 Q9Y6Q9 NCOA3    HPRD  PubMed  
    P10275 Q13772 NCOA4    HPRD  PubMed  
    P10275 O75376 NCOR1    HPRD  PubMed  
    P10275 Q9Y618 NCOR2    HPRD  PubMed  
    P10275 P19838 NFKB1    HPRD  PubMed  
    P10275 Nischarin NISCH    HPRD  PubMed  
    P10275 Q15233 NONO    HPRD  PubMed  
    P10275 P51843 NR0B1    HPRD  PubMed  
    P10275 Q15466 NR0B2    HPRD  PubMed  
    P10275 P13056 NR2C1    HPRD  PubMed  
    P10275 P49116 NR2C2    HPRD  PubMed  
    P10275 P04150 NR3C1    HPRD  PubMed  
    P10275 P08235 NR3C2    HPRD  PubMed  
    P10275 Q13285 NR5A1    HPRD  PubMed  
    P10275 P48552 NRIP1    HPRD  PubMed  
    P10275 Q96L73 NSD1    HPRD  PubMed  
    P10275 Q9UQ80 PA2G4    HPRD  PubMed  
    P10275 Q9NQU5 PAK6    HPRD  PubMed  
    P10275 O75925 PIAS1    HPRD  PubMed  
    P10275 O75928 PIAS2    HPRD  PubMed  
    P10275 Q9Y6X2 PIAS3    HPRD  PubMed  
    P10275 Q8N2W9 PIAS4    HPRD  PubMed  
    P10275 Q12796 PNRC1    HPRD  PubMed  
    P10275 Q9NPJ4 PNRC2    HPRD  PubMed  
    P10275 P14859 POU2F1    HPRD  PubMed  
    P10275 Q01860 POU5F1    HPRD  PubMed  
    P10275 Q99873 PRMT1    HPRD  PubMed  
    P10275 TBP 1 interacting protein PSMC3IP    HPRD  PubMed  
    P10275 P60484 PTEN    HPRD  PubMed  
    P10275 P49023 PXN    HPRD  PubMed  
    P10275 P60763 RAC3    HPRD  PubMed  
    P10275 RAD54-like 2 RAD54L2    HPRD  PubMed  
    P10275 Q99638 RAD9A    HPRD  PubMed  
    P10275 P04049 RAF1    HPRD  PubMed  
    P10275 P62826 RAN    HPRD  PubMed  
    P10275 Q96S59 RANBP9    HPRD  PubMed  
    P10275 P06400 RB1    HPRD  PubMed  
    P10275 RB associated KRAB repressor RBAK    HPRD  PubMed  
    P10275 Q96PM5 RCHY1    HPRD  PubMed  
    P10275 Q04206 RELA    HPRD  PubMed  
    P10275 Q05823 RNASEL    HPRD  PubMed  
    P10275 Q9UBS8 RNF14    HPRD  PubMed  
    P10275 P78317 RNF4    HPRD  PubMed  
    P10275 Q01196 RUNX1    HPRD  PubMed  
    P10275 Q13950 RUNX2    HPRD  PubMed  
    P10275 Q15020 SART3    HPRD  PubMed  
    P10275 P12235 SLC25A4    HPRD  PubMed  
    P10275 Q15797 SMAD1    HPRD  PubMed  
    P10275 P84022 SMAD3    HPRD  PubMed  
    P10275 Q13485 SMAD4    HPRD  PubMed  
    P10275 P08047 SP1    HPRD  PubMed  
    P10275 O95238 SPDEF    HPRD  PubMed  
    P10275 P12931 SRC    HPRD  PubMed  
    P10275 Q05066 SRY    HPRD  PubMed  
    P10275 P40763 STAT3    HPRD  PubMed  
    P10275 Q9UNE7 STUB1    HPRD  PubMed  
    P10275 P63165 SUMO1    HPRD  PubMed  
    P10275 O95425 SVIL    HPRD  PubMed  
    P10275 P15884 TCF4    HPRD  PubMed  
    P10275 HIC5 TGFB1I1    HPRD  PubMed  
    P10275 Q15583 TGIF1    HPRD  PubMed  
    P10275 P82094 TMF1    HPRD  PubMed  
    P10275 O15164 TRIM24    HPRD  PubMed  
    P10275 Q15650 TRIP4    HPRD  PubMed  
    P10275 Q99816 TSG101    HPRD  PubMed  
    P10275 P63279 UBE2I    HPRD  PubMed  
    P10275 Q05086 UBE3A    HPRD  PubMed  
    P10275 Q9UBK9 UXT    HPRD  PubMed  
    P10275 Q5MNZ9 WIPI1    HPRD  PubMed  
    P10275 P13010 XRCC5    HPRD  PubMed  
    P10275 P12956 XRCC6    HPRD  PubMed  
    P10275 Q9ULJ6 ZMIZ1    HPRD  PubMed  
    BioGRID:106862 BioGRID:106675 AES    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:106710 AKT1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:117522 APPL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:106862 AR    BioGRID  PubMed Co-crystal Structure; Protein-peptide; Two-hybrid 
    BioGRID:106862 BioGRID:116074 ARID5A    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:107049 BAG1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:107140 BRCA1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:107252 CALM1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:106862 BioGRID:107262 CALR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:107305 CAV1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:107067 CCND1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:107338 CCNE1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:107342 CCNH    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:107429 CDC25B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:116312 CDC37    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:107457 CDK7    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106862 BioGRID:107459 CDK9    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:107479 CEBPA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:107480 CEBPB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:121709 CHD8    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:114729 COPS2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:107722 COX5B    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:113587 DAP3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:107985 DAXX    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:120933 DCAF6    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106862 BioGRID:107998 DCC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:108010 DDB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:116861 DENND5A    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:113117 DNAJC7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:108201 E2F1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:108206 E2F4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:122306 EFCAB6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:108276 EGFR    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:106862 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:108380 ERCC2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:108383 ERCC3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:108389 ERG    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:108420 ETV5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:108565 FHL2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:108578 FKBP4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:108579 FKBP5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:108605 FLNA    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:109411 FOXA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:108597 FOXO1    BioGRID  PubMed Affinity Capture-Western; Far Western; Two-hybrid 
    BioGRID:106862 BioGRID:124721 GADD45GIP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:108868 GAPDH    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:115671 GNB2L1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:116995 GRIP1    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:109186 GSK3A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:109187 GSK3B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:109189 GSN    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:109217 GTF2F1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:109218 GTF2F2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:109220 GTF2H1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:109221 GTF2H2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:109222 GTF2H3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106862 BioGRID:114368 HDAC3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:115106 HDAC4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106862 BioGRID:119613 HDAC7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:109389 HMGB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:109391 HMGB2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:109414 HNF4A    BioGRID  PubMed Co-localization 
    BioGRID:106862 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:109535 HSPA1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:109548 HSPB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:109786 IL6ST    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:109928 JUN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:115779 KAT5    BioGRID  PubMed Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:116315 KAT7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:120927 KDM3A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:115035 KDM4A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:120819 KDM4D    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:115984 KDM5B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:107029 KIF1A    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:116582 KIFAP3    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:117727 LATS2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106862 BioGRID:124093 LCOR    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:110284 MAGEA11    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:111580 MAPK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex 
    BioGRID:106862 BioGRID:116804 MDN1    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:111465 MED1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:125538 MED12L    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:115196 MED24    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:117961 MLH3    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:114200 NCOA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:115761 NCOA2    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:113841 NCOA3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:113726 NCOA4    BioGRID  PubMed Far Western; Protein-peptide; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:116691 NCOA6    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106862 BioGRID:114973 NCOR1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Phenotypic Suppression; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:114974 NCOR2    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:119572 NELFCD    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:130709 NLRP10    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:110904 NONO    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:106695 NR0B1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:114012 NR0B2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:113033 NR2C1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106862 BioGRID:113034 NR2C2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:122135 NSD1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:111075 PA2G4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:121251 PAK6    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:116446 PARK7    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106862 BioGRID:117133 PATZ1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:111114 PAX6    BioGRID  PubMed Affinity Capture-Western; FRET; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:117973 PELP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:111264 PHB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:114124 PIAS1    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:114523 PIAS2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:115673 PIAS3    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:119624 PIAS4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:121262 PMEPA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:111447 POU2F1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:111448 POU2F2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:111477 PPID    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:111528 PPP5C    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:111577 PRKDC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106862 BioGRID:109512 PRMT1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:117298 PRPF6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:111675 PSMC3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:120558 PSPC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106862 BioGRID:111700 PTEN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:116750 RAD54L2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:111820 RAD9A    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106862 BioGRID:111831 RAF1    BioGRID  PubMed Co-purification 
    BioGRID:106862 BioGRID:111837 RAN    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:115359 RANBP9    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106862 BioGRID:111860 RB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:117406 RCHY1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:114622 REPS2    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:114968 RNF14    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:121119 RNF20    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:111974 RNF4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:115149 RNF40    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:111976 RNF6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:112153 RREB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:115082 SART3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:114472 SELENBP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:123332 SETD7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:112319 SFPQ    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:116901 SIN3B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:116983 SIRT1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Negative Genetic; Reconstituted Complex 
    BioGRID:106862 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:110264 SMAD4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:112479 SMARCA2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106862 BioGRID:112481 SMARCA4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106862 BioGRID:112483 SMARCC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:112486 SMARCD1    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:112489 SMARCE1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:117335 SPDEF    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:113993 SPOP    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:112592 SRC    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106862 BioGRID:116058 SRCAP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:112598 SREBF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:112614 SRY    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:112651 STAT3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:115563 STUB1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Protein-peptide; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:112707 SVIL    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:116740 TAB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:115737 TADA3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:112735 TAF1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:106862 BioGRID:122834 TBL1XR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:112771 TBP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:112802 TCF20    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:112787 TCF4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:112855 TDG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:112899 TGFB1I1    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:112908 TGIF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:112965 TMF1    BioGRID  PubMed Far Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:115485 TNK2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:113010 TP53    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:106862 BioGRID:114333 TRIM24    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:120434 TRIM68    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:113102 TSG101    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:113177 UBE2I    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement; Two-hybrid 
    BioGRID:106862 BioGRID:113185 UBE3A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:114554 USP10    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:106862 BioGRID:123764 USP26    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:113997 UXT    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:122532 WDR77    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:113306 WHSC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106862 BioGRID:113353 XRCC5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:116168 YWHAQ    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106862 BioGRID:116556 ZBTB1    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:113498 ZBTB16    BioGRID  PubMed Two-hybrid 
    BioGRID:106862 BioGRID:117964 ZBTB32    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:119488 ZBTB7A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106862 BioGRID:121427 ZMIZ1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106862 BioGRID:123701 ZMIZ2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106862 BioGRID:117299 ZNF318    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106862 BioGRID:117502 ZNF451    BioGRID  PubMed Affinity Capture-Western 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    POU domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA polymerase II transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    androgen binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    androgen receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    androgen receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    androgen receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    androgen receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    androgen receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    beta-catenin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    		  
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein dimerization activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    activation of prostate induction by androgen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cell proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    epithelial cell differentiation involved in prostate gland development IEA
    Inferred from Electronic Annotation
    more info
    		  
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lateral sprouting involved in mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    male genitalia morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    male gonad development IEA
    Inferred from Electronic Annotation
    more info
    		  
    male somatic sex determination IEA
    Inferred from Electronic Annotation
    more info
    		  
    mammary gland alveolus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    morphogenesis of an epithelial fold IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		  
    negative regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of integrin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		  
    organ formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of integrin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of intracellular estrogen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase III promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    prostate gland development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    prostate gland epithelium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    prostate gland growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein oligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of developmental growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of establishment of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    regulation of prostatic bud formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of systemic arterial blood pressure IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    sex differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    tertiary branching involved in mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		  
    transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    androgen receptor
    Names
    androgen receptor
    dihydrotestosterone receptor
    androgen nuclear receptor variant 2
    nuclear receptor subfamily 3 group C member 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009014.2 RefSeqGene

      Range
      5001..191588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000044.3 → NP_000035.2  androgen receptor isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI352339, AL049564, AL356358, L29496
      Consensus CDS
      CCDS14387.1
      UniProtKB/Swiss-Prot
      P10275
      Related
      ENSP00000363822, OTTHUMP00000023450, ENST00000374690, OTTHUMT00000057007
      Conserved Domains (3) summary
      pfam02166
      Location:6 – 449
      Blast Score: 1398
      Androgen_recep; Androgen receptor
      cd07073
      Location:673 – 918
      Blast Score: 1412
      NR_LBD_AR; Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
      cd07173
      Location:555 – 636
      Blast Score: 475
      NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers

    2. NM_001011645.2 → NP_001011645.1  androgen receptor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. The resulting isoform (2), also referred to as AR45, is shorter, and has a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AI352339, AL049564, AL356358, L29496
      Consensus CDS
      CCDS43965.1
      UniProtKB/TrEMBL
      F1D8N5
      UniProtKB/Swiss-Prot
      P10275
      Conserved Domains (2) summary
      cd07073
      Location:141 – 386
      Blast Score: 1363
      NR_LBD_AR; Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
      cd07173
      Location:23 – 104
      Blast Score: 467
      NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p10 Primary Assembly

      Range
      66763874..66950461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      60592006..60778929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018934.1 Alternate CHM1_1.0

      Range
      66771513..66958175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01067242.1 (5094..19594) None
    genomic ABBA01067243.1 None
    genomic ABBA01067244.1 None
    genomic ABBA01067245.1 None
    genomic ABBA01067246.1 None
    genomic ABBA01067247.1 None
    genomic ABBA01067248.1 None
    genomic ABBA01067249.1 None
    genomic ABBA01067250.1 None
    genomic ABBA01067251.1 None
    genomic ABBA01067252.1 None
    genomic ABBA01067253.1 None
    genomic ABBA01067254.1 None
    genomic ABBA01067255.1 None
    genomic ABBA01067256.1 None
    genomic ABBA01067257.1 None
    genomic ABBA01067258.1 None
    genomic ABBA01067259.1 None
    genomic ABBA01067260.1 None
    genomic ABBA01067261.1 None
    genomic AL049564.11 (102973..139033) None
    genomic AL158016.15 (100..70663) None
    genomic AL356358.19 (100..80064) None
    genomic AMYH01022515.1 (344086..346470) None
    genomic AMYH01022516.1 None
    genomic AMYH01022517.1 None
    genomic AX453758.1 None
    genomic CH471132.2 EAX05380.1
    genomic JB048765.1 CCV20035.1
    genomic M27430.1 AAA51886.1
    genomic M35851.1 AAA51772.1
    genomic M58158.1 AAA51778.1
    genomic S79366.1 AAB21256.2
    genomic S79368.1 AAB21257.2
    genomic U16371.1 AAB60346.1
    mRNA AF162704.1 AAD45921.1
    mRNA AF321914.1 AAK09423.1
    mRNA AF321915.1 AAK09424.1
    mRNA AF321916.1 AAK09425.1
    mRNA AF321917.1 AAK09426.1
    mRNA AI352339.1 None
    mRNA BC132975.1 AAI32976.1
    mRNA FJ235919.1 ACN39562.1
    mRNA FJ235920.1 ACN39563.1
    mRNA GU208210.1 ACZ81436.1
    mRNA HQ692823.1 ADZ17334.1
    mRNA L29496.1 AAA51770.1
    mRNA M20132.1 AAA51729.1
    mRNA M20260.1 AAA51774.1
    mRNA M21748.1 AAA51771.1
    mRNA M23263.1 AAA51775.1
    mRNA M34233.1 AAA51780.1
    mRNA M73069.1 AAA51735.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10275.2 GenPept UniProtKB/Swiss-Prot:P10275

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioAssay, by Gene target
        PubChem BioAssays done on the Gene target
      • BioAssay, by Protein Target
        BioAssay, by Protein Target
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • Books
        Links between Entrez Gene and 'Books' are established if a GeneID is explicitly referenced in a book.
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • ClinVar
        Related medical variations
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • GTR
        GTR associated with a gene
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • MedGen
        Related information in MedGen
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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