ISG20 interferon stimulated exonuclease gene 20kDa [Homo sapiens] - Gene

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Summary

Official Symbol: ISG20provided by HGNC
Official Full Name: interferon stimulated exonuclease gene 20kDaprovided by HGNC
Primary source: HGNC:6130
See related: Ensembl:ENSG00000172183; HPRD:05169; MIM:604533; Vega:OTTHUMG00000148679
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD25; HEM45

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Genomic context

Location :: 15q26

Sequence :: Chromosome: 15; NC_000015.9 (89182039..89198879)

See ISG20 in Epigenomics, MapViewer

Chromosome 15 - NC_000015.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ISG20 inhibited infections by hepatitis C virus, bovine viral diarrhea virus and hepatitis A virus. Moreover, ISG20 demonstrated cell-type specific antiviral activity against yellow fever virus, a classical flavivirus.
Title: Antiviral activities of ISG20 in positive-strand RNA virus infections.
ISG20 has a role in reducing the synthesis of HBV proteins
Title: Cloning, eukaryotic expression of human ISG20 and preliminary study on the effect of its anti-HBV.
ISG20has distinctive residues, Met14 and Arg53, to accommodate hydrogen bonds with the 2'-OH group of the UMP ribose, and these residues may be responsible for the preference of ISG20 for RNA substrates
Title: Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including HEM45, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Function	Evidence Code	Pubs
3'-5'-exoribonuclease activity	IDA Inferred from Direct Assay more info	PubMed
RNA binding	IEA Inferred from Electronic Annotation more info
exonuclease activity	IEA Inferred from Electronic Annotation more info
exoribonuclease II activity	IEA Inferred from Electronic Annotation more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
single-stranded DNA specific 3'-5' exodeoxyribonuclease activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
DNA catabolic process, exonucleolytic	IDA Inferred from Direct Assay more info	PubMed
RNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
cell proliferation	TAS Traceable Author Statement more info	PubMed
cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
innate immune response	IEA Inferred from Electronic Annotation more info
rRNA processing	IEA Inferred from Electronic Annotation more info
response to virus	IDA Inferred from Direct Assay more info	PubMed
type I interferon-mediated signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
PML body	IDA Inferred from Direct Assay more info	PubMed
intracellular	IEA Inferred from Electronic Annotation more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: interferon-stimulated gene 20 kDa protein

Names: interferon-stimulated gene 20 kDa protein; estrogen-regulated transcript 45 protein; promyelocytic leukemia nuclear body-associated protein ISG20

NP_002192.2

EC 3.1.13.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002201.4 → NP_002192.2 interferon-stimulated gene 20 kDa protein

Status: PROVISIONAL

Source sequence(s)

BC007922

Consensus CDS

CCDS10345.1

UniProtKB/Swiss-Prot

Q96AZ6

Related

ENSP00000306565, OTTHUMP00000192918, ENST00000306072, OTTHUMT00000309069

Conserved Domains (1) summary

cd06149
Location:8 – 163
Blast Score: 645

ISG20; DEDDh 3'-5' exonuclease domain of Interferon Stimulated Gene product of 20 kDa, and similar proteins

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000015.9 Reference GRCh37.p5 Primary Assembly

Range

89182039..89198879

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000147.1 Alternate HuRef

Range

65293925..65311076

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC104259.14 (53516..70356)	None
genomic	CH471101.1	EAX02013.1
		EAX02014.1
		EAX02015.1
		EAX02016.1
mRNA	AB209639.1	BAD92876.1
mRNA	AK307769.1	None
mRNA	BC007922.2	AAH07922.1
mRNA	BC016341.1	AAH16341.1
mRNA	BT006952.1	AAP35598.1
mRNA	CR456942.1	CAG33223.1
mRNA	U88964.1	AAB53416.1
mRNA	X89773.2	CAA61915.2