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Cep83 centrosomal protein 83 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366872, updated on 3-Apr-2024

Summary

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Official Symbol
Cep83provided by RGD
Official Full Name
centrosomal protein 83provided by RGD
Primary source
RGD:1359593
See related
Ensembl:ENSRNOG00000007859 AllianceGenome:RGD:1359593
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ccdc41; RGD1359593
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in cilium assembly and vesicle docking. Predicted to act upstream of or within establishment of centrosome localization and protein localization to centrosome. Predicted to be located in Golgi apparatus and centriole. Predicted to be part of ciliary transition fiber. Human ortholog(s) of this gene implicated in nephronophthisis 18. Orthologous to human CEP83 (centrosomal protein 83). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 257.2), Brain (RPKM 180.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q13
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (31167198..31276513)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (29280358..29389574)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (35739553..35847618)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit f, pseudogene 3 Neighboring gene centrosomal protein 83, opposite strand Neighboring gene uncharacterized LOC120093560 Neighboring gene plexin C1 Neighboring gene uncharacterized LOC134479861 Neighboring gene uncharacterized LOC120093559

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CCDC41 is required for ciliary vesicle docking to the mother centriole. Joo K, et al. Proc Natl Acad Sci U S A, 2013 Apr 9. PMID 23530209, Free PMC Article
  2. Centriole distal appendages promote membrane docking, leading to cilia initiation. Tanos BE, et al. Genes Dev, 2013 Jan 15. PMID 23348840, Free PMC Article
  3. C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals. Ye X, et al. Proc Natl Acad Sci U S A, 2014 Feb 11. PMID 24469809, Free PMC Article
  4. Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development. Shultz MA, et al. Am J Respir Cell Mol Biol, 2004 Mar. PMID 12947022
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in establishment of centrosome localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment of centrosome localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle docking ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ciliary transition fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ciliary transition fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centrosomal protein of 83 kDa
Names
coiled-coil domain containing 41
coiled-coil domain-containing protein 41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014266.2 → NP_001014288.1  centrosomal protein of 83 kDa

    See identical proteins and their annotated locations for NP_001014288.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q66H89
    UniProtKB/TrEMBL
    A6IG23
    Related
    ENSRNOP00000031786.4, ENSRNOT00000034639.5
    Conserved Domains (1) summary
    COG1196
    Location:39 → 622
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    31167198..31276513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264031.1 → XP_063120101.1  centrosomal protein of 83 kDa isoform X2

    UniProtKB/Swiss-Prot
    Q66H89
    UniProtKB/TrEMBL
    A6IG23

  2. XM_063264027.1 → XP_063120097.1  centrosomal protein of 83 kDa isoform X1

  3. XM_063264030.1 → XP_063120100.1  centrosomal protein of 83 kDa isoform X1

  4. XM_063264032.1 → XP_063120102.1  centrosomal protein of 83 kDa isoform X3

  5. XM_063264036.1 → XP_063120106.1  centrosomal protein of 83 kDa isoform X8

  6. XM_008765317.4 → XP_008763539.1  centrosomal protein of 83 kDa isoform X4

    Conserved Domains (2) summary
    COG1196
    Location:39 → 622
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19219
    Location:157 → 234
    DUF342; Protein of unknown function (DUF342)

  7. XM_063264035.1 → XP_063120105.1  centrosomal protein of 83 kDa isoform X6

  8. XM_039079678.2 → XP_038935606.1  centrosomal protein of 83 kDa isoform X7

    Conserved Domains (2) summary
    COG1196
    Location:39 → 267
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:172 → 507
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  9. XM_063264037.1 → XP_063120107.1  centrosomal protein of 83 kDa isoform X9

  10. XM_063264034.1 → XP_063120104.1  centrosomal protein of 83 kDa isoform X5

  11. XM_063264042.1 → XP_063120112.1  centrosomal protein of 83 kDa isoform X14

  12. XM_063264041.1 → XP_063120111.1  centrosomal protein of 83 kDa isoform X13

  13. XM_063264038.1 → XP_063120108.1  centrosomal protein of 83 kDa isoform X10

  14. XM_063264039.1 → XP_063120109.1  centrosomal protein of 83 kDa isoform X11

  15. XM_063264043.1 → XP_063120113.1  centrosomal protein of 83 kDa isoform X14

  16. XM_063264033.1 → XP_063120103.1  centrosomal protein of 83 kDa isoform X4

  17. XM_063264026.1 → XP_063120096.1  centrosomal protein of 83 kDa isoform X1

  18. XM_017595016.3 → XP_017450505.1  centrosomal protein of 83 kDa isoform X2

    UniProtKB/Swiss-Prot
    Q66H89
    UniProtKB/TrEMBL
    A6IG23
    Conserved Domains (1) summary
    COG1196
    Location:39 → 622
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  19. XM_063264028.1 → XP_063120098.1  centrosomal protein of 83 kDa isoform X1

  20. XM_063264040.1 → XP_063120110.1  centrosomal protein of 83 kDa isoform X12

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66H89.1 GenPept UniProtKB/Swiss-Prot:Q66H89

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