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Agps Alkylglycerone phosphate synthase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36669, updated on 4-Apr-2024

Summary

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Official Symbol
Agpsprovided by FlyBase
Official Full Name
Alkylglycerone phosphate synthaseprovided by FlyBase
Primary source
FLYBASE:FBgn0033983
Locus tag
Dmel_CG10253
See related
AllianceGenome:FB:FBgn0033983
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ADPS; AGPS; CG10253; dAGPS; Dmel\CG10253
Summary
Predicted to enable FAD binding activity and alkylglycerone-phosphate synthase activity. Predicted to be involved in ether lipid biosynthetic process. Located in peroxisome. Is expressed in several structures, including embryonic maxillary sensory complex; extended germ band embryo; lateral cord neurons; presumptive embryonic/larval system; and ventral midline of embryo. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctata and rhizomelic chondrodysplasia punctata type 3. Orthologous to human AGPS (alkylglycerone phosphate synthase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Agps in Genome Data Viewer
Location:
51D3-51D3; 2-73 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14929703..14934861, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10817208..10822366, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 6a8 Neighboring gene Cytochrome P450 317a1 Neighboring gene kank Neighboring gene uncharacterized protein Neighboring gene Lap1 Neighboring gene uncharacterized protein Neighboring gene atypical protein kinase C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identifying a recombinant alkyldihydroxyacetonephosphate synthase suited for crystallographic studies. Razeto A, et al. Protein Expr Purif, 2007 Oct. PMID 17601746
  2. Reducing ether lipids improves Drosophila overnutrition-associated pathophysiology phenotypes via a switch from lipid storage to beta-oxidation. Santoro C, et al. Sci Rep, 2022 Jul 29. PMID 35906462, Free PMC Article
  3. New regulators of Drosophila eye development identified from temporal transcriptome changes. Quiquand M, et al. Genetics, 2021 Apr 15. PMID 33681970, Free PMC Article
  4. GMAP is an Atg8a-interacting protein that regulates Golgi turnover in Drosophila. Rahman A, et al. Cell Rep, 2022 May 31. PMID 35649355, Free PMC Article
  5. Regulators of autophagosome formation in Drosophila muscles. Zirin J, et al. PLoS Genet, 2015 Feb. PMID 25692684, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables FAD binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables alkylglycerone-phosphate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alkylglycerone-phosphate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables alkylglycerone-phosphate synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ether lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISM
Inferred from Sequence Model
more info
 PubMed 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
alkylglycerone phosphate synthase
Names
Agps-PA
Agps-PB
Agps-PC
Agps-PD
CG10253-PA
CG10253-PB
CG10253-PC
CG10253-PD
alkyldihydroxyacetonephosphate synthase
NP_001188935.1
NP_001188936.1
NP_001188937.1
NP_611006.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14929703..14934861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202007.2 → NP_001188936.1  alkylglycerone phosphate synthase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188936.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V778
    UniProtKB/TrEMBL
    A0A0B4JD21, D5SHU3
    Conserved Domains (3) summary
    COG0277
    Location:152 → 612
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    pfam01565
    Location:159 → 300
    FAD_binding_4; FAD binding domain
    pfam02913
    Location:337 → 608
    FAD-oxidase_C; FAD linked oxidases, C-terminal domain

  2. NM_001202006.1 → NP_001188935.1  alkylglycerone phosphate synthase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188935.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V778
    UniProtKB/TrEMBL
    A0A0B4JD21, D5SHU3
    Conserved Domains (3) summary
    COG0277
    Location:152 → 612
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    pfam01565
    Location:159 → 300
    FAD_binding_4; FAD binding domain
    pfam02913
    Location:337 → 608
    FAD-oxidase_C; FAD linked oxidases, C-terminal domain

  3. NM_001202008.1 → NP_001188937.1  alkylglycerone phosphate synthase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188937.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V778
    UniProtKB/TrEMBL
    A0A0B4JD21, D5SHU3
    Conserved Domains (3) summary
    COG0277
    Location:152 → 612
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    pfam01565
    Location:159 → 300
    FAD_binding_4; FAD binding domain
    pfam02913
    Location:337 → 608
    FAD-oxidase_C; FAD linked oxidases, C-terminal domain

  4. NM_137162.3 → NP_611006.1  alkylglycerone phosphate synthase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611006.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V778
    UniProtKB/TrEMBL
    A0A0B4JD21, D5SHU3
    Related
    FBpp0086558
    Conserved Domains (3) summary
    COG0277
    Location:152 → 612
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    pfam01565
    Location:159 → 300
    FAD_binding_4; FAD binding domain
    pfam02913
    Location:337 → 608
    FAD-oxidase_C; FAD linked oxidases, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JD21 A0A0B4JD21
Q9V778.1 Q9V778

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