Ercc1 [Drosophila melanogaster] - Gene

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Summary

Official Symbol: Ercc1provided by Flybase
Primary source: FLYBASE:FBgn0028434
Locus tag: Dmel_CG10215
Gene type: protein coding
RNA name: Ercc1
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10215; Dmel\CG10215; ERCC1

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Genomic context

Location :: 51C5-51C5

Sequence :: Chromosome: 2R; NT_033778.3 (10740470..10741453)

See Ercc1 in Epigenomics, MapViewer

Chromosome 2R - NT_033778.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

HDM, MEI-9, MUS312, and ERCC1 form a complex that resolves meiotic recombination intermediates into crossovers.
Title: Drosophila hold'em is required for a subset of meiotic crossovers and interacts with the dna repair endonuclease complex subunits MEI-9 and ERCC1.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:62399	BioGRID:62397	CG10209	BioGRID	PubMed	Two-hybrid
BioGRID:62399	BioGRID:58700	CG11164	BioGRID	PubMed	Two-hybrid
BioGRID:62399	BioGRID:59864	CG15631	BioGRID	PubMed	Two-hybrid
BioGRID:62399	BioGRID:77495	CG33052	BioGRID	PubMed	Two-hybrid
BioGRID:62399	BioGRID:61695	CG8642	BioGRID	PubMed	Two-hybrid
BioGRID:62399	BioGRID:57914	HLH4C	BioGRID	PubMed	Two-hybrid
BioGRID:62399	BioGRID:57875	Xpac	BioGRID	PubMed	Two-hybrid
BioGRID:62399	BioGRID:60495	cdc2	BioGRID	PubMed	Two-hybrid
BioGRID:62399	BioGRID:59586	cpb	BioGRID	PubMed	Two-hybrid
BioGRID:62399	BioGRID:57890	mei-9	BioGRID	PubMed	Two-hybrid
BioGRID:62399	BioGRID:68973	pie	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the Ercc1 gene: The Ercc1 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, zebrafish, mosquito, S.pombe, , N.crassa, A.thaliana, and rice.

Pathways from BioSystems

DNA Repair, organism-specific biosystem (from REACTOME)
DNA Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dual incision reaction in GG-NER, organism-specific biosystem (from REACTOME)
Dual incision reaction in GG-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dual incision reaction in TC-NER, organism-specific biosystem (from REACTOME)
Dual incision reaction in TC-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Fanconi anemia pathway, organism-specific biosystem (from KEGG)
Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
Fanconi anemia pathway, conserved biosystem (from KEGG)
Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
Formation of incision complex in GG-NER, organism-specific biosystem (from REACTOME)
Formation of incision complex in GG-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Global Genomic NER (GG-NER), organism-specific biosystem (from REACTOME)
Global Genomic NER (GG-NER), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
Nucleotide Excision Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nucleotide excision repair, organism-specific biosystem (from KEGG)
Nucleotide excision repair, organism-specific biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
Nucleotide excision repair, conserved biosystem (from KEGG)
Nucleotide excision repair, conserved biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
Transcription-coupled NER (TC-NER), organism-specific biosystem (from REACTOME)
Transcription-coupled NER (TC-NER), organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
damaged DNA binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
single-stranded DNA specific endodeoxyribonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to single-stranded DNA specific endodeoxyribonuclease activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
nucleotide-excision repair	IMP Inferred from Mutant Phenotype more info	PubMed
nucleotide-excision repair, DNA incision, 5'-to lesion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
nucleus	IEA Inferred from Electronic Annotation more info
protein complex	IDA Inferred from Direct Assay more info	PubMed

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General protein information

Preferred Names: CG10215 gene product from transcript CG10215-RA

Names: CG10215-PA; Ercc1; Ercc1-PA

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.3

Range

10740470..10741453

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058120.2 → NP_477468.1 Ercc1 [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q7KMG7

Related

FBpp0086578, FBtr0087448

Conserved Domains (2) summary

COG5241
Location:1 – 257
Blast Score: 331

RAD10; Nucleotide excision repair endonuclease NEF1, RAD10 subunit [DNA replication, recombination, and repair]

cl04283
Location:61 – 173
Blast Score: 346

Rad10; Binding domain of DNA repair protein Ercc1 (rad10/Swi10)