My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    IRF7 interferon regulatory factor 7 [ Homo sapiens ]

    Gene ID: 3665, updated on 19-May-2012
    Help top of page

    Summary

    Official Symbol
    IRF7provided by HGNC
    Official Full Name
    interferon regulatory factor 7provided by HGNC
    Primary source
    HGNC:6122
    See related
    Ensembl:ENSG00000185507; HPRD:05441; MIM:605047; Vega:OTTHUMG00000132019
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IRF7A; IRF-7H
    Summary
    IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]
    Help top of page

    Genomic context

    Location :
    11p15.5
    Sequence :
    Chromosome: 11; NC_000011.9 (612555..615999, complement)
    See IRF7 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC143666 Neighboring gene PHD and ring finger domains 1 Neighboring gene cadherin-related family member 5 Neighboring gene secretin

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. TRAF6 and IRF7 control HIV replication in macrophages. Sirois M, et al. PLoS One, 2011. PMID 22140520.
    2. Guanylate binding protein 4 negatively regulates virus-induced type I IFN and antiviral response by targeting IFN regulatory factor 7. Hu Y, et al. J Immunol, 2011 Dec 15. PMID 22095711.
    3. Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7. Liang Q, et al. J Immunol, 2011 Nov 1. PMID 21940674.
    4. Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7. Unterholzner L, et al. PLoS Pathog, 2011 Sep. PMID 21931555.
    5. Novel identification of the IRF7 region as an anticentromere autoantibody propensity locus in systemic sclerosis. Carmona FD, et al. Ann Rheum Dis, 2012 Jan. PMID 21926187.

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. TRAF6 can regulate HIV-1 production and expression of IRF7 promotes HIV-1 replication.
      Title: TRAF6 and IRF7 control HIV replication in macrophages.
    2. IRF7 region is an anticentromere autoantibody propensity locus in systemic sclerosis
      Title: Novel identification of the IRF7 region as an anticentromere autoantibody propensity locus in systemic sclerosis.
    3. Vaccinia virus protein C6 inhibits the activation of IRF7 by TBK1- and IKKepsilon-dependent pathways.
      Title: Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7.
    4. The ubiquitin E3 ligase activity of tripartite motif-containing (TRIM)28 protein is specific to IRF7.
      Title: Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7.
    5. Cigarette smoke suppresses key plasmacytoid dendritic cells functions upon viral infection by a mechanism that involves downregulation of TLR7 expression and decreased activation of IRF-7.
      Title: Cigarette smoke suppresses TLR-7 stimulation in response to virus infection in plasmacytoid dendritic cells.
    6. Study did not find signi fi cant relationships between rs4963128 or rs2246614 of IRF7/KIAA1542 and the risk of systemic lupus erythematosus, differing from a previous study of European women
      Title: Association of genetic variations in the STAT4 and IRF7/KIAA1542 regions with systemic lupus erythematosus in a Northern Han Chinese population.
    7. analysis of IFN-stimulated response elements (ISREs) that bind to both the IFN-stimulated gene factor 3 (ISGF3) as well as to IFN response factor 7 (IRF7)
      Title: Transcription factor redundancy ensures induction of the antiviral state.
    8. ORF45 may maintain the IRF-7 molecule in the closed form and prevent it from being activated in response to viral infection
      Title: Mechanisms of autoinhibition of IRF-7 and a probable model for inactivation of IRF-7 by Kaposi's sarcoma-associated herpesvirus protein ORF45.
    9. These findings demonstrate that the lysine residues of IRF-7 play important roles in mediating IFN synthesis and modulating viral lytic replication.
      Title: Lysine residues of interferon regulatory factor 7 affect the replication and transcription activator-mediated lytic replication of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8.
    10. Neurovirulence of interferon-resistant rabies virus correlates with the capacity of the virus phosphoprotein to prevent activation of IRF3 and IRF7.
      Title: Genetic dissection of interferon-antagonistic functions of rabies virus phosphoprotein: inhibition of interferon regulatory factor 3 activation is important for pathogenicity.
    Submit: New GeneRIF Correction See all (56)
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including IFN regulatory factor 7A (IRF7), in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001563.2 NP_002459.1 MYD88    BIND  PubMed IRF7 interacts with MyD88. 
    NP_001563.2 NP_004611.1 TRAF6    BIND  PubMed IRF7 intereacts with TRAF6. This interaction was modeled on a demonstrated interaction between mouse IRF7 and human TRAF6. 
    NP_001563.2 AAC34946.1     BIND  PubMed RTA interacts with and ubiquitinates IRF7. 
    Q92985 Q92793 CREBBP    HPRD  PubMed  
    Q92985 Q09472 EP300    HPRD  PubMed  
    Q92985 P51617 IRAK1    HPRD  PubMed  
    Q92985 Q14653 IRF3    HPRD  PubMed  
    Q92985 Q92830 KAT2A    HPRD  PubMed  
    Q92985 Q92831 KAT2B    HPRD  PubMed  
    Q92985 KIAA1271 protein MAVS    HPRD  PubMed  
    Q92985 Q99836 MYD88    HPRD  PubMed  
    Q92985 Q8N2W9 PIAS4    HPRD  PubMed  
    Q92985 Toll-like receptor adaptor molecule 1 TICAM1    HPRD  PubMed  
    Q92985 Toll like receptor adaptor molecule 2 TICAM2    HPRD  PubMed  
    Q92985 Q9Y4K3 TRAF6    HPRD  PubMed  
    BioGRID:109873 BioGRID:114511 AIP    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109873 BioGRID:106739 ALK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109873 BioGRID:106864 ARAF    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109873 BioGRID:121318 CCDC47    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109873 BioGRID:107777 CREBBP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109873 BioGRID:108347 EP300    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109873 BioGRID:114302 FADD    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109873 BioGRID:201474 Gbp4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109873 BioGRID:121590 HACE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109873 BioGRID:115250 IQSEC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109873 BioGRID:109863 IRAK1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109873 BioGRID:109869 IRF3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109873 BioGRID:109873 IRF7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109873 BioGRID:118028 KIAA1274    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109873 BioGRID:117509 LTN1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109873 BioGRID:110700 MYD88    BioGRID  PubMed Affinity Capture-Western; FRET; Two-hybrid 
    BioGRID:109873 BioGRID:111072 P4HA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109873 BioGRID:115328 TANK    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109873 BioGRID:116201 TLK2    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109873 BioGRID:112983 TNFAIP3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109873 BioGRID:113041 TRAF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109873 BioGRID:112615 TRIM21    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109873 BioGRID:117968 TRMT2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109873 BioGRID:120338 TRMT61B    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109873 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
      Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
    • Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, organism-specific biosystem (from REACTOME)
      Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, organism-specific biosystemCell stimulation with viral ds RNA leads to the activation of two IKK-related serine/threonine kinases, TBK1 and IKK-i which directly phosphorylate IRF3 and IRF7 promoting their dimerization and tran...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
      Interferon alpha/beta signaling, organism-specific biosystemType I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, wher...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
      MyD88 dependent cascade initiated on endosome, organism-specific biosystemUpon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I ...
    • MyD88-independent cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88-independent cascade initiated on plasma membrane, organism-specific biosystemThe MyD88-independent signaling route utilizes TRAM and TRIF adapters, that are essential for production of both type 1 interferons(IFNs) and pro-inflammatory cytokines. TRAM is thought to bridge bet...
    • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
      RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
    • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
      RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
    • Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
      Regulation of nuclear SMAD2/3 signaling
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • TRAF3-dependent IRF activation pathway, organism-specific biosystem (from REACTOME)
      TRAF3-dependent IRF activation pathway, organism-specific biosystemIPS-1/MAVS/Cardif/VISA with its TRAF-interaction motif (TIM) directly interacts with TRAF3 and recruits TRAF3 to the RIG-I/MDA5 signaling complex. TRAF3 acts as a scaffold for the assembly of a signa...
    • TRAF6 mediated IRF7 activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated IRF7 activation, organism-specific biosystemTRAF6 is crucial for both RIG-I- and MDA5-mediated antiviral responses. The absence of TRAF6 resulted in enhanced viral replication and a significant reduction in the production of type I IFNs and IL...
    • TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling, organism-specific biosystem (from REACTOME)
      TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling, organism-specific biosystemIn plasmacytoid dendritic cell induction of type I IFNs critically depends on IFN regulatory factor 7 in TLR7 and 9 signaling (Honda et al 2005). IRF-7, but not IRF3, interacts with MyD88, TRAF6, and...
    • TRIF mediated TLR3 signaling, organism-specific biosystem (from REACTOME)
      TRIF mediated TLR3 signaling, organism-specific biosystemTIR-domain-containing adaptor inducing interferon-beta (TRIF or TIKAM1) is known to be an essential and exclusive adaptor used by TLR3; all the poly(I:C)-induced pathways leading to NFkB and IRF3 act...
    • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemToll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and in...
    • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
    • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
    • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
    • Toll Receptor Cascades, organism-specific biosystem (from REACTOME)
      Toll Receptor Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, organism-specific biosystem (from REACTOME)
      Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, organism-specific biosystemCell stimulation with viral ds RNA leads to the activation of two IKK-related serine/threonine kinases, TBK1 and IKK-i which directly phosphorylate IRF3 and IRF7 promoting their dimerization and tran...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    regulatory region DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    MyD88-independent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    TRIF-dependent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Toll signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of interferon-alpha production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    toll-like receptor 3 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor 4 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    type I interferon-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    endosome membrane TAS
    Traceable Author Statement
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    interferon regulatory factor 7
    Names
    interferon regulatory factor 7
    IRF-7
    interferon regulatory factor-7H
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029106.1 RefSeqGene

      Range
      5001..8445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001572.3 → NP_001563.2  interferon regulatory factor 7 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) has an alternate 5' UTR and 5' coding region, compared to variant d. The resulting isoform (a) is shorter and has a distinct N-terminus compared to isoform d.
      Source sequence(s)
      AF076494, BM849172, U53830, U53831, U73036
      Consensus CDS
      CCDS7703.1
      UniProtKB/Swiss-Prot
      Q92985
      Related
      ENSP00000380704, OTTHUMP00000162887, ENST00000397574, OTTHUMT00000255026
      Conserved Domains (2) summary
      cd00103
      Location:11 – 124
      Blast Score: 285
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
      pfam10401
      Location:286 – 466
      Blast Score: 477
      IRF-3; Interferon-regulatory factor 3

    2. NM_004029.2 → NP_004020.1  interferon regulatory factor 7 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) has an alternate 5' UTR, 5' coding region and lacks an alternate in-frame exon, compared to variant d. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform d.
      Source sequence(s)
      AF076494, BM849172, U53831
      Consensus CDS
      CCDS7704.1
      UniProtKB/Swiss-Prot
      Q92985
      Related
      ENSP00000380700, ENST00000397570
      Conserved Domains (2) summary
      cd00103
      Location:11 – 124
      Blast Score: 284
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
      pfam10401
      Location:257 – 437
      Blast Score: 473
      IRF-3; Interferon-regulatory factor 3

    3. NM_004031.2 → NP_004022.2  interferon regulatory factor 7 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) encodes the longest isoform (d).
      Source sequence(s)
      AF076494, DA601567, DA967682, U53830, U53831
      Consensus CDS
      CCDS7705.1
      UniProtKB/Swiss-Prot
      Q92985
      Related
      ENSP00000380697, ENST00000397566
      Conserved Domains (2) summary
      cd00103
      Location:24 – 137
      Blast Score: 283
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
      pfam10401
      Location:299 – 479
      Blast Score: 474
      IRF-3; Interferon-regulatory factor 3

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      612555..615999, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      427860..431281, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_004030.1: Suppressed sequence

      Description
      NM_004030.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF277159.1 AAG30003.1
    genomic AP006284.2 (71270..74642) None
    genomic CH471158.1 EAX02355.1
      EAX02356.1
      EAX02357.1
      EAX02358.1
      EAX02359.1
      EAX02360.1
    mRNA AF076494.1 AAC70999.1
    mRNA AK303752.1 BAG64723.1
    mRNA BC136555.1 AAI36556.1
    mRNA BC144242.1 None
    mRNA BM849172.1 None
    mRNA DA601567.1 None
    mRNA DA967682.1 None
    mRNA U53830.1 AAB80686.1
    mRNA U53831.1 AAB80688.1
    mRNA U53832.1 AAB80690.1
      AAB80691.1
    mRNA U73036.1 AAB17190.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92985.2 GenPept UniProtKB/Swiss-Prot:Q92985
    Q9HB64 GenPept UniProtKB/TrEMBL:Q9HB64
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...