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CG10104 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36602, updated on 4-Apr-2024

Summary

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Official Symbol
CG10104provided by FlyBase
Primary source
FLYBASE:FBgn0033933
Locus tag
Dmel_CG10104
See related
AllianceGenome:FB:FBgn0033933
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG10104
Summary
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in cell death. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in several diseases, including familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension (multiple); neuronal ceroid lipofuscinosis 10; and portal hypertension. Orthologous to several human genes including CTSD (cathepsin D). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
51A1-51A1; 2-71 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14390696..14392209)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10278201..10279714)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Diuretic hormone 44 receptor 1 Neighboring gene long non-coding RNA:CR44369 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative genomics reveals a constant rate of origination and convergent acquisition of functional retrogenes in Drosophila. Bai Y, et al. Genome Biol, 2007. PMID 17233920, Free PMC Article
  2. Parent genes of retrotransposition-generated gene duplicates in Drosophila melanogaster have distinct expression profiles. Langille MG, et al. Genomics, 2007 Sep. PMID 17628393
  3. Nuclear chromosome dynamics in the Drosophila male germ line contribute to the nonrandom genomic distribution of retrogenes. Díaz-Castillo C, et al. Mol Biol Evol, 2012 Sep. PMID 22427708
  4. The genetic architecture of odor-guided behavior in Drosophila melanogaster. Anholt RR, et al. Behav Genet, 2001 Jan. PMID 11529271
  5. An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination. Kanca O, et al. Elife, 2022 Jun 20. PMID 35723254, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell death IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG10104-PA
NP_610961.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14390696..14392209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137117.2 → NP_610961.1  uncharacterized protein Dmel_CG10104 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610961.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z9Q9, Q8MZF3
    Related
    FBpp0086615
    Conserved Domains (3) summary
    pfam00026
    Location:84 → 402
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:28 → 54
    A1_Propeptide; A1 Propeptide
    cl11403
    Location:76 → 400
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z9Q9 A1Z9Q9
Q8MZF3 Q8MZF3

Gene LinkOut

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