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    Sox15 Sox box protein 15 [ Drosophila melanogaster ]

    Gene ID: 36575, updated on 10-May-2012
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    Summary

    Official Symbol
    Sox15provided by Flybase
    Official Full Name
    Sox box protein 15provided by Flybase
    Primary source
    FLYBASE:FBgn0005613
    Locus tag
    Dmel_CG8404
    Gene type
    protein coding
    RNA name
    Sox box protein 15
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13945; CG8404; Dmel\CG8404; Dsox-15; DSox-15; Sox F; SOX15; Sox50E; SOX50E; SoxE; SoxF; SOXF
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    Genomic context

    Location :
    50E4-50E4
    Sequence :
    Chromosome: 2R; NT_033778.3 (10088888..10099914, complement)
    See Sox15 in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene CG30069 gene product from transcript CG30069-RA Neighboring gene Vesicular GABA Transporter Neighboring gene mir-308 stem loop Neighboring gene Ribosomal protein S23 Neighboring gene CG8468 gene product from transcript CG8468-RC Neighboring gene optic atrophy 1-like

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Parallel on-chip gene synthesis and application to optimization of protein expression. Quan J, et al. Nat Biotechnol, 2011 May. PMID 21516083.
    2. The gene regulatory cascade linking proneural specification with differentiation in Drosophila sensory neurons. Cachero S, et al. PLoS Biol, 2011 Jan 4. PMID 21283833.
    3. Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. Blanco E, et al. BMC Dev Biol, 2010 Sep 2. PMID 20813047.
    4. Complex interplay of three transcription factors in controlling the tormogen differentiation program of Drosophila mechanoreceptors. Miller SW, et al. Dev Biol, 2009 May 15. PMID 19232522.
    5. SoxF is part of a novel negative-feedback loop in the wingless pathway that controls proliferation in the Drosophila wing disc. Dichtel-Danjoy ML, et al. Development, 2009 Mar. PMID 19176582.

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. new feedback loop in the wg pathway in which the spatially restricted activation of the Sox gene SoxF (Sox15) by wg represses its own transcription, thus ensuring tight regulation of growth control
      Title: SoxF is part of a novel negative-feedback loop in the wingless pathway that controls proliferation in the Drosophila wing disc.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:62325 BioGRID:60468 CG13138    BioGRID  PubMed Two-hybrid 
    BioGRID:62325 BioGRID:72655 CG14634    BioGRID  PubMed Two-hybrid 
    BioGRID:62325 BioGRID:67567 CG7080    BioGRID  PubMed Two-hybrid 
    BioGRID:62325 BioGRID:66304 by    BioGRID  PubMed Two-hybrid 
    BioGRID:62325 BioGRID:61396 gus    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    chaeta development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    chaeta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    negative regulation of transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    wing disc development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CG8404 gene product from transcript CG8404-RA
    Names
    CG8404-PA
    Sox box protein 15
    Sox15-PA
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      10088888..10099914, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079015.2 → NP_523739.2  Sox box protein 15 [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40657
      Related
      FBpp0086702, FBtr0087576
      Conserved Domains (2) summary
      cd01388
      Location:214 – 285
      Blast Score: 263
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      PHA03273
      Location:305 – 391
      Blast Score: 100
      PHA03273; envelope glycoprotein C; Provisional
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA BT025204.1 ABF17895.1
    genomic AE013599.4 AAF58279.2
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40657.2 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content