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    IRAK2 interleukin-1 receptor-associated kinase 2 [ Homo sapiens ]

    Gene ID: 3656, updated on 19-May-2012
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    Summary

    Official Symbol
    IRAK2provided by HGNC
    Official Full Name
    interleukin-1 receptor-associated kinase 2provided by HGNC
    Primary source
    HGNC:6113
    See related
    Ensembl:ENSG00000134070; HPRD:04491; MIM:603304; Vega:OTTHUMG00000155358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IRAK-2; MGC150550
    Summary
    IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    3p25.3
    Sequence :
    Chromosome: 3; NC_000003.11 (10206563..10285427)
    See IRAK2 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene BRICK1, SCAR/WAVE actin-nucleating complex subunit Neighboring gene von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase Neighboring gene TatD DNase domain containing 2 Neighboring gene ghrelin opposite strand RNA 2 (non-protein coding)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Li S, et al. Immunity, 2011 Sep 23. PMID 21903422.
    3. Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha. Flannery SM, et al. J Biol Chem, 2011 Jul 8. PMID 21606490.
    4. Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression. Xiong Y, et al. J Biol Chem, 2011 Mar 11. PMID 21220427.
    5. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. Casabonne D, et al. Haematologica, 2011 Feb. PMID 21048031.

    See all (38) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha.
      Title: Human interleukin-1 receptor-associated kinase-2 is essential for Toll-like receptor-mediated transcriptional and post-transcriptional regulation of tumor necrosis factor alpha.
    2. analysis of differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease
      Title: Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease.
    3. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
    4. Our data show that interleukin-1R-associated kinase 2 is a novel and critical component of TGFbeta signaling.
      Title: Interleukin-1R-associated kinase 2 is a novel modulator of the transforming growth factor beta signaling cascade.
    5. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.
    6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    7. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    8. the crystal structure of the MyD88-IRAK4-IRAK2 death domain (DD) complex, which surprisingly reveals a left-handed helical oligomer that consists of 6 MyD88, 4 IRAK4 and 4 IRAK2 DDs
      Title: Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling.
    9. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
    Submit: New GeneRIF Correction See all (13)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001561.2 NP_001560.1 IRAK1    BIND  PubMed IRAK interacts with IRAK-2 and forms a heterocomplex. 
    NP_001561.2 NP_001561.2 IRAK2    BIND  PubMed IRAK-2 interacts with itself and forms a homocomplex. 
    NP_001561.2 NP_009130.1 IRAK3    BIND  PubMed IRAK-2 interacts with IRAK-M. 
    NP_001561.2 NP_002459.1 MYD88    BIND  PubMed IRAK-2 interacts with MyD88. 
    NP_001561.2 NP_067681.1 TICAM2    BIND  PubMed TIRP interacts with IRAK-2. 
    NP_001561.2 NP_004611.1 TRAF6    BIND  PubMed IRAK-2 interacts with TRAF6. 
    O43187 P01112 HRAS    HPRD  PubMed  
    O43187 P14778 IL1R1    HPRD  PubMed  
    O43187 P51617 IRAK1    HPRD  PubMed  
    O43187 O43187 IRAK2    HPRD  PubMed  
    O43187 Q9Y616 IRAK3    HPRD  PubMed  
    O43187 Q99836 MYD88    HPRD  PubMed  
    O43187 Q15796 SMAD2    HPRD  PubMed  
    O43187 Q9HCE7 SMURF1    HPRD  PubMed  
    O43187 Toll like receptor adaptor molecule 2 TICAM2    HPRD  PubMed  
    O43187 P58753 TIRAP    HPRD  PubMed  
    O43187 O00206 TLR4    HPRD  PubMed  
    O43187 Q9Y4K3 TRAF6    HPRD  PubMed  
    BioGRID:109865 BioGRID:121312 ADCK3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109865 BioGRID:106864 ARAF    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109865 BioGRID:114907 BAG3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109865 BioGRID:116312 CDC37    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109865 BioGRID:121924 FASTKD5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109865 BioGRID:109770 IL1R1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109865 BioGRID:115015 IQCB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109865 BioGRID:115250 IQSEC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109865 BioGRID:109863 IRAK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109865 BioGRID:116382 IRAK3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109865 BioGRID:119322 IRAK4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109865 BioGRID:110455 MME    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109865 BioGRID:110700 MYD88    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression 
    BioGRID:109865 BioGRID:121418 PELI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109865 BioGRID:121417 PELI2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109865 BioGRID:128900 PELI3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109865 BioGRID:116726 SARM1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109865 BioGRID:124826 SESTD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109865 BioGRID:116661 SNRNP200    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109865 BioGRID:109908 STT3A    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109865 BioGRID:117003 TARDBP    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109865 BioGRID:125325 TIRAP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Phenotypic Suppression 
    BioGRID:109865 BioGRID:112953 TLR3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109865 BioGRID:112983 TNFAIP3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109865 BioGRID:119978 TOLLIP    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109865 BioGRID:113041 TRAF6    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109865 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109865 BioGRID:120257 YTHDF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109865 BioGRID:123141 ZC3H12A    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:109865 BioGRID:124547 ZC3H12C    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
      Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • IL-1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-1 Signaling Pathway, organism-specific biosystemThe interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor,...
    • IRAK2 mediated activation of TAK1 complex, organism-specific biosystem (from REACTOME)
      IRAK2 mediated activation of TAK1 complex, organism-specific biosystemAlthough IRAK-1 was originally thought to be a key mediator of TRAF6 activation in the IL1R/TLR signaling (Dong W et al. 2006), recent studies showed that IRAK-2, but not IRAK-1, led to TRAF6 polyubi...
    • IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, organism-specific biosystem (from REACTOME)
      IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, organism-specific biosystemAlthough IRAK-1 was originally thought to be a key mediator of TRAF6 activation in the IL1R/TLR signaling (Dong W et al. 2006), recent studies showed that IRAK-2, but not IRAK-1, led to TRAF6 polyubi...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-1 signaling, organism-specific biosystemInterleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL1R1), the only signaling-capable IL1 receptor. This is a single chain type 1 transmembrane protein comprising an extracellular ligand bindi...
    • JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, organism-specific biosystem (from REACTOME)
      JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, organism-specific biosystemC-Jun NH2 terminal kinases (JNKs) are an evolutionarily conserved family of serine/threonine protein kinases, that belong to mitogen activated protein kinase family (MAPKs - also known as stress-acti...
    • MAP kinase activation in TLR cascade, organism-specific biosystem (from REACTOME)
      MAP kinase activation in TLR cascade, organism-specific biosystemMitogen activated protein kinase (MAPK) cascade, one of the most ancient and evolutionarily conserved signaling pathways, is involved in many processes of immune responses. The MAP kinases cascade tr...
    • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88 cascade initiated on plasma membrane, organism-specific biosystemMammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of...
    • MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
      MyD88 dependent cascade initiated on endosome, organism-specific biosystemUpon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I ...
    • MyD88-independent cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88-independent cascade initiated on plasma membrane, organism-specific biosystemThe MyD88-independent signaling route utilizes TRAM and TRIF adapters, that are essential for production of both type 1 interferons(IFNs) and pro-inflammatory cytokines. TRAM is thought to bridge bet...
    • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
    • NFkB and MAP kinases activation mediated by TLR4 signaling repertoire, organism-specific biosystem (from REACTOME)
      NFkB and MAP kinases activation mediated by TLR4 signaling repertoire, organism-specific biosystemMitogen activated protein kinase (MAPK) cascade, one of the most ancient and evolutionarily conserved signaling pathways, is involved in many processes of immune responses. The MAP kinases cascade tr...
    • NOD1/2 Signaling Pathway, organism-specific biosystem (from REACTOME)
      NOD1/2 Signaling Pathway, organism-specific biosystemNOD1 is ubiquitously expressed, while NOD2 expression is restricted to monocytes, macrophages, dendritic cells, and intestinal Paneth cells (Inohara et al. 2005). NOD1 and NOD2 activation induces tra...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
      Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemThe innate immune system is the first line of defense against invading microorganisms, a broad specificity response characterized by the recruitment and activation of phagocytes and the release of an...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystem (from REACTOME)
      TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystemNF-kappaB is sequestered in the cytoplasm in a complex with inhibitor of NF-kappaB (IkB). Almost all NF-kappaB activation pathways are mediated by IkB kinase (IKK), which phosphorylates IkB resulting...
    • TRAF6 Mediated Induction of proinflammatory cytokines, organism-specific biosystem (from REACTOME)
      TRAF6 Mediated Induction of proinflammatory cytokines, organism-specific biosystemIn human, together with ubiquitin-conjugating E2-type enzymes UBC13 and UEV1A (also known as UBE2V1), TRAF6 catalyses Lys63-linked ubiquitination. It is believed that auto polyubiquitination and oli...
    • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemTRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
    • TRAF6 mediated induction of TAK1 complex, organism-specific biosystem (from REACTOME)
      TRAF6 mediated induction of TAK1 complex, organism-specific biosystemIn human, together with ubiquitin-conjugating E2-type enzymes UBC13 and UEV1A (also known as UBE2V1), TRAF6 catalyses Lys63-linked ubiquitination. It is believed that auto polyubiquitination and oli...
    • TRIF mediated TLR3 signaling, organism-specific biosystem (from REACTOME)
      TRIF mediated TLR3 signaling, organism-specific biosystemTIR-domain-containing adaptor inducing interferon-beta (TRIF or TIKAM1) is known to be an essential and exclusive adaptor used by TLR3; all the poly(I:C)-induced pathways leading to NFkB and IRF3 act...
    • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
    • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
    • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemToll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and in...
    • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
    • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
    • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
    • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
    • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
    • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
    • Toll Receptor Cascades, organism-specific biosystem (from REACTOME)
      Toll Receptor Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • activated TAK1 mediates p38 MAPK activation, organism-specific biosystem (from REACTOME)
      activated TAK1 mediates p38 MAPK activation, organism-specific biosystemp38 mitogen-activated protein kinase (MAPK) belongs to a highly conserved family of serine/threonine protein kinases. The p38 MAPK-dependent signaling cascade is activated by pro-inflammatory or stre...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    I-kappaB kinase/NF-kappaB cascade TAS
    Traceable Author Statement
    more info
    		  
    JNK cascade TAS
    Traceable Author Statement
    more info
    		  
    MyD88-dependent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    MyD88-independent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    TRIF-dependent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Toll signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    activation of MAPK activity TAS
    Traceable Author Statement
    more info
    		  
    inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    interleukin-1-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    nucleotide-binding oligomerization domain containing signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of NF-kappaB transcription factor activity TAS
    Traceable Author Statement
    more info
    		  
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to interleukin-1 IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    stress-activated MAPK cascade TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor 1 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor 2 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor 3 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor 4 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    endosome membrane TAS
    Traceable Author Statement
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    interleukin-1 receptor-associated kinase-like 2
    Names
    interleukin-1 receptor-associated kinase-like 2
    interleukin-1 receptor associated kinase-2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001570.3 → NP_001561.3  interleukin-1 receptor-associated kinase-like 2

      Status: REVIEWED

      Source sequence(s)
      AC022384, AF026273, AJ496794, AL538890, AL556221, BG682610
      Consensus CDS
      CCDS33697.1
      UniProtKB/Swiss-Prot
      O43187
      Related
      ENSP00000256458, OTTHUMP00000207789, ENST00000256458, OTTHUMT00000339623
      Conserved Domains (2) summary
      cd00180
      Location:216 – 407
      Blast Score: 321
      PKc; Catalytic domain of Protein Kinases
      cd08795
      Location:3 – 91
      Blast Score: 449
      Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      10206563..10285427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      10142464..10221162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC022384.5 (44079..122943) None
    genomic CH471055.1 EAW64069.1
    mRNA AF026273.1 AAB87669.1
    mRNA AJ496794.1 CAD43180.3
    mRNA AK299033.1 BAG61108.1
    mRNA AK312841.1 BAG35695.1
    mRNA AL538890.3 None
    mRNA AL556221.3 None
    mRNA BC125184.1 AAI25185.1
    mRNA BG682610.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43187.2 GenPept UniProtKB/Swiss-Prot:O43187
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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