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    mam mastermind [ Drosophila melanogaster ]

    Gene ID: 36555, updated on 19-May-2012
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    Summary

    Official Symbol
    mamprovided by Flybase
    Official Full Name
    mastermindprovided by Flybase
    Primary source
    FLYBASE:FBgn0002643
    Locus tag
    Dmel_CG8118
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8118; Dm0064; dMam; Dmel\CG8118; l(2)03505; l(2)04615; Mam; mam(CAG)[[7]]; N-2G; SR2-4
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    Genomic context

    Location :
    50C23-50D3; 2-70.3 cM
    Sequence :
    Chromosome: 2R; NT_033778.3 (9878686..9947861)
    See mam in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene CG8067 gene product from transcript CG8067-RA Neighboring gene CG13350 gene product from transcript CG13350-RA Neighboring gene tre oncogene-related protein Neighboring gene mir-4978 stem loop Neighboring gene CG18371 gene product from transcript CG18371-RA Neighboring gene CG30483 gene product from transcript CG30483-RB Neighboring gene CG42287 gene product from transcript CG42287-RA Neighboring gene CG42288 gene product from transcript CG42288-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin. Janody F, et al. Dev Dyn, 2011 Sep. PMID 21793099.
    2. The effects of weak genetic perturbations on the transcriptome of the wing imaginal disc and its association with wing shape in Drosophila melanogaster. Dworkin I, et al. Genetics, 2011 Apr. PMID 21288875.
    3. EndoGI modulates Notch signaling and axon guidance in Drosophila. O'Keefe DD, et al. Mech Dev, 2011 Jan-Feb. PMID 21055464.
    4. Modifiers of notch transcriptional activity identified by genome-wide RNAi. Mourikis P, et al. BMC Dev Biol, 2010 Oct 19. PMID 20959007.
    5. Robust target gene discovery through transcriptome perturbations and genome-wide enhancer predictions in Drosophila uncovers a regulatory basis for sensory specification. Aerts S, et al. PLoS Biol, 2010 Jul 27. PMID 20668662.

    See all (206) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Genes activated by Notch signaling at the dorsal-ventral boundary of wing disc fall into classes affected differently by the loss of kinase module subunits. The distinctions do not result from different requirements for Groucho.
      Title: Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin.
    2. Results identify Mastermind, the Notch pathway transcriptional co-activator, as a rare dose-dependent modifier of aberrant follicle stem cell expansion induced by excess Hedgehog.
      Title: Hedgehog-stimulated stem cells depend on non-canonical activity of the Notch co-activator Mastermind.
    3. The findings in this study suggest Mam is not always necessary and sufficient for co-activation of binary Su(H)/NICD complexes on SPS elements.
      Title: Promoter-specific co-activation by Drosophila mastermind.
    4. Mam protein might associate during the asymmetric specification of cell fates and the N-terminal region of the protein plays a role in this process.
      Title: Differential effects of Drosophila mastermind on asymmetric cell fate specification and neuroblast formation.
    5. an alternative product of the mastermind locus that represses notch signalling
      Title: A naturally occurring alternative product of the mastermind locus that represses notch signalling.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:62308 BioGRID:63843 CG1240    BioGRID  PubMed Two-hybrid 
    BioGRID:62308 BioGRID:61933 CG12934    BioGRID  PubMed Two-hybrid 
    BioGRID:62308 BioGRID:59833 CG17612    BioGRID  PubMed Two-hybrid 
    BioGRID:62308 BioGRID:63447 CG3328    BioGRID  PubMed Two-hybrid 
    BioGRID:62308 BioGRID:65182 CG9715    BioGRID  PubMed Two-hybrid 
    BioGRID:62308 BioGRID:66325 Crc    BioGRID  PubMed Two-hybrid 
    BioGRID:62308 BioGRID:67310 Dl    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:62308 BioGRID:58322 Dsor1    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:62308 BioGRID:67070 Fas1    BioGRID  PubMed Two-hybrid 
    BioGRID:62308 BioGRID:60480 GATAd    BioGRID  PubMed Two-hybrid 
    BioGRID:62308 BioGRID:67421 H    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:62308 BioGRID:63485 Letm1    BioGRID  PubMed Two-hybrid 
    BioGRID:62308 BioGRID:58924 Mfe2    BioGRID  PubMed Two-hybrid 
    BioGRID:62308 BioGRID:57823 N    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:62308 BioGRID:78261 Nipped-B    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:62308 BioGRID:65518 Psn    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:62308 BioGRID:66301 Ras85D    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:62308 BioGRID:78269 RpL38    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:62308 BioGRID:68163 Ser    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:62308 BioGRID:60899 Su(H)    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:62308 BioGRID:58586 Ten-a    BioGRID  PubMed Two-hybrid 
    BioGRID:62308 BioGRID:62854 Topors    BioGRID  PubMed Two-hybrid 
    BioGRID:62308 BioGRID:59621 aop    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:62308 BioGRID:57697 arm    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:62308 BioGRID:69119 ct    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:62308 BioGRID:58490 dsh    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:62308 BioGRID:58076 dx    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:62308 BioGRID:65366 fz2    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:62308 BioGRID:57556 l(1)sc    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:62308 BioGRID:69697 l(3)82Fd    BioGRID  PubMed Two-hybrid 
    BioGRID:62308 BioGRID:69357 mys    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:62308 BioGRID:57758 phl    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:62308 BioGRID:58454 sev    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:62308 BioGRID:57779 sgg    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:62308 BioGRID:69991 shi    BioGRID  PubMed Two-hybrid 
    BioGRID:62308 BioGRID:58658 sno    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:62308 BioGRID:64862 stv    BioGRID  PubMed Two-hybrid 
    BioGRID:62308 BioGRID:66816 su(Hw)    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:62308 BioGRID:60155 wg    BioGRID  PubMed Phenotypic Enhancement 
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    General gene information

    Markers

    Pathways from BioSystems

    • Notch signaling pathway, organism-specific biosystem (from KEGG)
      Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Notch signaling pathway, conserved biosystem (from KEGG)
      Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Notch signaling pathway NAS
    Non-traceable Author Statement
    more info
    		  
    apposition of dorsal and ventral imaginal disc-derived wing surfaces IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    chaeta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    compound eye development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    ectoderm development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    germ-line stem cell maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    imaginal disc-derived wing margin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mesodermal cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nervous system development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    somatic stem cell maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
    polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    polytene chromosome puff IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG8118 gene product from transcript CG8118-RA
    Names
    CG8118-PA
    CG8118-PB
    CG8118-PC
    mam-PA
    mam-PB
    mam-PC
    master mind
    mastermind
    NP_995831.1
    • unusual splice
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      9878686..9947861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080376.1 → NP_525115.1  mastermind, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P21519
      Related
      FBpp0086722, FBtr0087596
      Conserved Domains (1) summary
      pfam09596
      Location:126 – 178
      Blast Score: 172
      MamL-1; MamL-1 domain

    2. NM_166030.1 → NP_725354.1  mastermind, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P21519
      Related
      FBpp0086723, FBtr0087597
      Conserved Domains (1) summary
      pfam09596
      Location:126 – 178
      Blast Score: 172
      MamL-1; MamL-1 domain

    3. NM_206109.1 → NP_995831.1  mastermind, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P21519
      Related
      FBpp0086724, FBtr0087598
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE013599.4 AAF58300.2
    genomic AE013599.4 AAF58299.1
    genomic AE013599.4 AAS64855.1
    mRNA BT044353.1 ACH92418.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21519.2 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content