CG6543 [Drosophila melanogaster] - Gene

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Summary

Official Symbol: CG6543provided by Flybase
Primary source: FLYBASE:FBgn0033879
Locus tag: Dmel_CG6543
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18645; Dmel\CG6543

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Genomic context

Location :: 50C6-50C6

Sequence :: Chromosome: 2R; NT_033778.3 (9740452..9741879, complement)

See CG6543 in Epigenomics, MapViewer

Chromosome 2R - NT_033778.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:62290	BioGRID:64858	CG10133	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:61187	CG10750	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:64736	CG11534	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:65741	CG12768	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:66332	CG16817	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:61131	CG17323	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:61582	CG2064	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:76950	CG31229	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:60414	CG31712	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:77306	CG31920	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:59139	CG32549	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:57935	CG32772	BioGRID	PubMed	Two-hybrid
BioGRID:62290	BioGRID:72704	CG34168	BioGRID	PubMed	Two-hybrid
BioGRID:62290	BioGRID:62459	CG8195	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:59902	CG8891	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:66690	CtBP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:61549	Inos	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:60023	Kr-h2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:65742	Mes2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:62181	Nacalpha	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:58882	PGRP-LE	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:59788	Spindly	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:61868	TER94	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:66512	dpr5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:60454	eEF1delta	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:60097	homer	BioGRID	PubMed	Two-hybrid
BioGRID:62290	BioGRID:61223	ref(2)P	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:64732	ssp	BioGRID	PubMed	Affinity Capture-MS
BioGRID:62290	BioGRID:68196	wdb	BioGRID	PubMed	Two-hybrid

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General gene information

Pathways from BioSystems

Beta Oxidation Meta MAPP, organism-specific biosystem (from WikiPathways)
Beta Oxidation Meta MAPP, organism-specific biosystem
Beta Oxidation Meta MAPP
Beta oxidation of butanoyl-CoA to acetyl-CoA, organism-specific biosystem (from REACTOME)
Beta oxidation of butanoyl-CoA to acetyl-CoA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA, organism-specific biosystem (from REACTOME)
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Beta oxidation of hexanoyl-CoA to butanoyl-CoA, organism-specific biosystem (from REACTOME)
Beta oxidation of hexanoyl-CoA to butanoyl-CoA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA, organism-specific biosystem (from REACTOME)
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Beta oxidation of octanoyl-CoA to hexanoyl-CoA, organism-specific biosystem (from REACTOME)
Beta oxidation of octanoyl-CoA to hexanoyl-CoA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Butanoate metabolism, organism-specific biosystem (from KEGG)
Butanoate metabolism, organism-specific biosystem
Butanoate metabolism
Butanoate metabolism, conserved biosystem (from KEGG)
Butanoate metabolism, conserved biosystem
Butanoate metabolism
Fatty Acid Beta Oxidation 1, organism-specific biosystem (from WikiPathways)
Fatty Acid Beta Oxidation 1, organism-specific biosystem
Fatty Acid Beta Oxidation 1
Fatty Acid Beta Oxidation 2, organism-specific biosystem (from WikiPathways)
Fatty Acid Beta Oxidation 2, organism-specific biosystem
Fatty Acid Beta Oxidation 2
Fatty Acid Beta Oxidation 3, organism-specific biosystem (from WikiPathways)
Fatty Acid Beta Oxidation 3, organism-specific biosystem
Fatty Acid Beta Oxidation 3
Fatty Acid Biosynthesis, organism-specific biosystem (from WikiPathways)
Fatty Acid Biosynthesis, organism-specific biosystem
Fatty Acid Biosynthesis
Fatty acid biosynthesis, elongation, mitochondria, organism-specific biosystem (from KEGG)
Fatty acid biosynthesis, elongation, mitochondria, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Fatty acid metabolism
Fatty acid biosynthesis, elongation, mitochondria, conserved biosystem (from KEGG)
Fatty acid biosynthesis, elongation, mitochondria, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Fatty acid metabolism
Fatty acid elongation, organism-specific biosystem (from KEGG)
Fatty acid elongation, organism-specific biosystem
Fatty acid elongation
Fatty acid elongation, conserved biosystem (from KEGG)
Fatty acid elongation, conserved biosystem
Fatty acid elongation
Fatty acid metabolism, organism-specific biosystem (from KEGG)
Fatty acid metabolism, organism-specific biosystem
Fatty acid metabolism
Fatty acid metabolism, conserved biosystem (from KEGG)
Fatty acid metabolism, conserved biosystem
Fatty acid metabolism
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Lysine degradation, organism-specific biosystem (from KEGG)
Lysine degradation, organism-specific biosystem
Lysine degradation
Lysine degradation, conserved biosystem (from KEGG)
Lysine degradation, conserved biosystem
Lysine degradation
Metabolic pathways, organism-specific biosystem (from KEGG)
Metabolic pathways, organism-specific biosystem
Metabolic pathways
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Mitochondrial Fatty Acid Beta-Oxidation, organism-specific biosystem (from REACTOME)
Mitochondrial Fatty Acid Beta-Oxidation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Propanoate metabolism, organism-specific biosystem (from KEGG)
Propanoate metabolism, organism-specific biosystem
Propanoate metabolism
Propanoate metabolism, conserved biosystem (from KEGG)
Propanoate metabolism, conserved biosystem
Propanoate metabolism
Tryptophan metabolism, organism-specific biosystem (from KEGG)
Tryptophan metabolism, organism-specific biosystem
Tryptophan metabolism
Tryptophan metabolism, conserved biosystem (from KEGG)
Tryptophan metabolism, conserved biosystem
Tryptophan metabolism
Valine, leucine and isoleucine degradation, organism-specific biosystem (from KEGG)
Valine, leucine and isoleucine degradation, organism-specific biosystem
Valine, leucine and isoleucine degradation
Valine, leucine and isoleucine degradation, conserved biosystem (from KEGG)
Valine, leucine and isoleucine degradation, conserved biosystem
Valine, leucine and isoleucine degradation
beta-Alanine metabolism, organism-specific biosystem (from KEGG)
beta-Alanine metabolism, organism-specific biosystem
beta-Alanine metabolism
beta-Alanine metabolism, conserved biosystem (from KEGG)
beta-Alanine metabolism, conserved biosystem
beta-Alanine metabolism
beta-Oxidation, organism-specific biosystem (from KEGG)
beta-Oxidation, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Fatty acid metabolism
beta-Oxidation, conserved biosystem (from KEGG)
beta-Oxidation, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Fatty acid metabolism
mitochondrial fatty acid beta-oxidation of saturated fatty acids, organism-specific biosystem (from REACTOME)
mitochondrial fatty acid beta-oxidation of saturated fatty acids, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enoyl-CoA hydratase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
lipid particle	IDA Inferred from Direct Assay more info	PubMed
microtubule associated complex	IDA Inferred from Direct Assay more info	PubMed
mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

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General protein information

Preferred Names: CG6543 gene product from transcript CG6543-RA

Names: CG6543; CG6543-PA; CG6543-PB

NP_610910.1

EC 4.2.1.17

NP_725332.1

EC 4.2.1.17

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.3

Range

9740452..9741879, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_137066.3 → NP_610910.1 CG6543, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q7JR58

Related

FBpp0086769

Conserved Domains (2) summary

cd06558
Location:41 – 234
Blast Score: 569

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

PRK05862
Location:37 – 294
Blast Score: 961

PRK05862; enoyl-CoA hydratase; Provisional
NM_166014.2 → NP_725332.1 CG6543, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q7JR58

Related

FBpp0086770

Conserved Domains (2) summary

cd06558
Location:41 – 234
Blast Score: 569

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

PRK05862
Location:37 – 294
Blast Score: 961

PRK05862; enoyl-CoA hydratase; Provisional