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Calr3 calreticulin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364529, updated on 5-Mar-2024

Summary

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Official Symbol
Calr3provided by RGD
Official Full Name
calreticulin 3provided by RGD
Primary source
RGD:1309243
See related
Ensembl:ENSRNOG00000013260 AllianceGenome:RGD:1309243
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein folding chaperone. Predicted to be involved in protein folding and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum lumen and nuclear envelope. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human CALR3 (calreticulin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 367.3), Kidney (RPKM 35.7) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
16p14
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (17430105..17456777)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (17396064..17423166)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19097391..19124062)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member E1 Neighboring gene similar to human chromosome 19 open reading frame 44 Neighboring gene calcium homeostasis endoplasmic reticulum protein Neighboring gene epidermal growth factor receptor pathway substrate 15-like 1 Neighboring gene KLF transcription factor 2 Neighboring gene adaptor related protein complex 1 subunit mu 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Calreticulin-2 is localized in the lumen of the endoplasmic reticulum but is not a Ca2+ -binding protein. Nomura R, et al. Histochem Cell Biol, 2011 Jun. PMID 21590275
  2. Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility [corrected]. Tokuhiro K, et al. Proc Natl Acad Sci U S A, 2012 Mar 6. PMID 22357757, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calreticulin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012212.1 → NP_001012212.1  calreticulin-3 precursor

    See identical proteins and their annotated locations for NP_001012212.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079049
    UniProtKB/TrEMBL
    F7EM31, Q6AYG8
    Related
    ENSRNOP00000018018.4, ENSRNOT00000018018.6
    Conserved Domains (1) summary
    pfam00262
    Location:23 → 315
    Calreticulin; Calreticulin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    17430105..17456777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094712.2 → XP_038950640.1  calreticulin-3 isoform X1

    Conserved Domains (1) summary
    pfam00262
    Location:23 → 257
    Calreticulin; Calreticulin family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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