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    TppII tripeptidyl-peptidase II [ Drosophila melanogaster ]

    Gene ID: 36444, updated on 10-May-2012
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    Summary

    Official Symbol
    TppIIprovided by Flybase
    Official Full Name
    tripeptidyl-peptidase IIprovided by Flybase
    Primary source
    FLYBASE:FBgn0020370
    Locus tag
    Dmel_CG3991
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.127; CG3991; Dmel\CG3991; dTPP II; dTPPII; l(2)k14301; TPP II; TPP2; TPPII
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    Genomic context

    Location :
    49F4-49F4
    Sequence :
    Chromosome: 2R; NT_033778.3 (9040393..9046595, complement)
    See TppII in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene CG34438 gene product from transcript CG34438-RF Neighboring gene Fak-like tyrosine kinase Neighboring gene CG33007 gene product from transcript CG33007-RA Neighboring gene CG34439 gene product from transcript CG34439-RB Neighboring gene Neurospecific receptor kinase Neighboring gene CG15870 gene product from transcript CG15870-RA Neighboring gene Glial Lazarillo

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Molecular ruler of tripeptidylpeptidase II: mechanistic principle of exopeptidase selectivity. Peters J, et al. Biochem Biophys Res Commun, 2011 Oct 14. PMID 21946061.
    2. Hybrid molecular structure of the giant protease tripeptidyl peptidase II. Chuang CK, et al. Nat Struct Mol Biol, 2010 Aug. PMID 20676100.
    3. The transcriptional response of Drosophila melanogaster to infection with the sigma virus (Rhabdoviridae). Carpenter J, et al. PLoS One, 2009 Aug 31. PMID 19718442.
    4. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.
    5. The Release 5.1 annotation of Drosophila melanogaster heterochromatin. Smith CD, et al. Science, 2007 Jun 15. PMID 17569856.

    See all (21) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. a systematic kinetic analysis of wild type Drosophila melanogaster TPPII and five point mutants of the double-Glu-motif (E312/E343) involving natural substrates were performed.
      Title: Molecular ruler of tripeptidylpeptidase II: mechanistic principle of exopeptidase selectivity.
    2. The structure suggests a model for activation of TPP II involving the relocation of a flexible loop and a repositioning of the active-site serine, coupling it to holocomplex assembly and active-site sequestration.
      Title: Hybrid molecular structure of the giant protease tripeptidyl peptidase II.
    3. the unique spindle form of the holo-complex of TPP II represents an assembly motif stabilizing a highly active state
      Title: Size matters for the tripeptidylpeptidase II complex from Drosophila: The 6-MDa spindle form stabilizes the activated state.
    4. The 150 kDa subunits of TPPII form a superstructure composed of 2 segmented & twisted strands. Each strand is 12.5 nm in width & composed of 11 segments that enclose a central channel.
      Title: A giant protease with a twist: the TPP II complex from Drosophila studied by electron microscopy.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:62211 BioGRID:57949 CG3323    BioGRID  PubMed Two-hybrid 
    BioGRID:62211 BioGRID:66862 CG43162    BioGRID  PubMed Two-hybrid 
    BioGRID:62211 BioGRID:67391 CG4367    BioGRID  PubMed Two-hybrid 
    BioGRID:62211 BioGRID:67993 MED28    BioGRID  PubMed Two-hybrid 
    BioGRID:62211 BioGRID:62760 MED9    BioGRID  PubMed Two-hybrid 
    BioGRID:62211 BioGRID:67360 RhoGAP92B    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the TppII gene: The TppII gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.pombe, A.thaliana, and rice.

    mobile_element

    • Loc: c9043520-9043488 mobile_element_type = transposon:INE-1{}5010

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    exopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    tripeptidyl-peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    tripeptidyl-peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG3991 gene product from transcript CG3991-RD
    Names
    CG3991-PA
    CG3991-PD
    TppII-PA
    TppII-PD
    Tripeptidyl-peptidase II
    tripeptidyl peptidase II
    tripeptidyl-peptidase II
    tripeptidylpeptidase II
    NP_477247.1
    NP_725252.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      9040393..9046595, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165966.1 → NP_725252.1  tripeptidyl-peptidase II, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V6K1
      Related
      FBpp0086887, FBtr0087774
      Conserved Domains (4) summary
      pfam12583
      Location:1156 – 1258
      Blast Score: 399
      TPPII_N; Tripeptidyl peptidase II N terminal
      cd04857
      Location:282 – 589
      Blast Score: 1352
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam12580
      Location:892 – 1079
      Blast Score: 718
      TPPII; Tripeptidyl peptidase II
      cl10459
      Location:101 – 212
      Blast Score: 413
      Peptidases_S8_S53; Peptidase domain in the S8 and S53 families

    2. NM_057899.2 → NP_477247.1  tripeptidyl-peptidase II, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V6K1
      Related
      FBpp0086888, FBtr0087775
      Conserved Domains (4) summary
      pfam12583
      Location:1069 – 1171
      Blast Score: 399
      TPPII_N; Tripeptidyl peptidase II N terminal
      cd04857
      Location:195 – 502
      Blast Score: 1350
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam12580
      Location:805 – 992
      Blast Score: 720
      TPPII; Tripeptidyl peptidase II
      cl10459
      Location:14 – 125
      Blast Score: 412
      Peptidases_S8_S53; Peptidase domain in the S8 and S53 families
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE013599.4 AAF58422.2
    mRNA BT044288.1 ACH92353.1
    mRNA BT003260.1 AAO25017.1
    genomic AE013599.4 AAM68593.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V6K1.2 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

      Supplemental Content