INSM1 insulinoma-associated 1 [Homo sapiens] - Gene

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Summary

Official Symbol: INSM1provided by HGNC
Official Full Name: insulinoma-associated 1provided by HGNC
Primary source: HGNC:6090
See related: Ensembl:ENSG00000173404; HPRD:02480; MIM:600010; Vega:OTTHUMG00000032004
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IA1; IA-1
Summary: Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 20p11.2

Sequence :: Chromosome: 20; NC_000020.10 (20348765..20351593)

See INSM1 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Both the AR42J cell line and the primary cultured mouse acinar cells support role for INSM1 in pancreatic acinar cell trans-differentiation model.
Title: Functional role of an islet transcription factor, INSM1/IA-1, on pancreatic acinar cell trans-differentiation.
The results suggest that INSM1 up-regulation plays a positive role in HSV-1 replication, probably by binding to the ICP0 promoter.
Title: Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor INSM1, which modulates the expression and localization of the immediate early protein ICP0.
The INSM1 promoter can direct herpes simplex virus thymidine kinase gene expression in a nude mouse model of neuroendocrine cancer and effectively repress tumor growth in response to ganciclovir treatment.
Title: INSM1 promoter-driven adenoviral herpes simplex virus thymidine kinase cancer gene therapy for the treatment of primitive neuroectodermal tumors.
Data show that the consistent functional effect of INSM1, either with or without other ITFs, promotes pancreatic duct cell differentiation as well as induces Panc-1 cell cycle arrest.
Title: Insulinoma-associated antigen-1 zinc-finger transcription factor promotes pancreatic duct cell trans-differentiation.
INSM1 role as an important regulator during neuroendocrine differentiation [review]
Title: Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation.
INSM1 is a new zinc-finger transcription factor that modulates insulin gene transcription during early pancreas development.
Title: Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription.
in mice and humans, INSM1 is likewise expressed transiently during terminal neurogenic divisions, from late progenitors to nascent neurons, and particularly during symmetric neuronogenic divisions.
Title: Transient expression of the conserved zinc finger gene INSM1 in progenitors and nascent neurons throughout embryonic and adult neurogenesis.
results presented in this study define INSM1 as a transcriptional repressor of the neuroD/b2 gene. The molecular mechanism of INSM1 transcriptional repression is attributed to the recruitment of cyclin D1 and HDAC-1 and -3
Title: INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases.
IA-1 gene is developmentally expressed in the nervous system and the NeuroD1/E47 transcription factors up-regulate IA-1 gene expression through the proximal E-box element of the IA-1 promoter
Title: NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system.
IA-1 gene was shown to be developmentally regulated in fetal pancreatic cells, and its expression pattern is consistent with parallel changes in islet-specific transcription factors during the endocrine differentiation of AR42J cells.
Title: Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q01101	P24385	CCND1	HPRD	PubMed
Q01101	Q13368	MPP3	HPRD	PubMed
Q01101	Q9BX66	SORBS1	HPRD	PubMed
Q01101	Q13509	TUBB3	HPRD	PubMed
BioGRID:109853	BioGRID:107067	CCND1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:109853	BioGRID:109315	HDAC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109853	BioGRID:114368	HDAC3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109853	BioGRID:115831	SORBS1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:109853	BioGRID:115654	TUBB3	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cell differentiation	IEA Inferred from Electronic Annotation more info
endocrine pancreas development	TAS Traceable Author Statement more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
intracellular	IEA Inferred from Electronic Annotation more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: insulinoma-associated protein 1

Names: insulinoma-associated protein 1; zinc finger protein IA-1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.