INPPL1 inositol polyphosphate phosphatase-like 1 [Homo sapiens] - Gene

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Summary

Official Symbol: INPPL1provided by HGNC
Official Full Name: inositol polyphosphate phosphatase-like 1provided by HGNC
Primary source: HGNC:6080
See related: Ensembl:ENSG00000165458; HPRD:02900; MIM:600829; Vega:OTTHUMG00000167879
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SHIP2
Summary: The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]

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Genomic context

Location :: 11q13

Sequence :: Chromosome: 11; NC_000011.9 (71935882..71950191)

See INPPL1 in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SHIP2 suppresses ligand-induced activation of EphA2 and promotes receptor coordinated chemotactic cell migration.
Title: NMR structure of a heterodimeric SAM:SAM complex: characterization and manipulation of EphA2 binding reveal new cellular functions of SHIP2.
Caveolin-1 knockdown by small interfering RNA reduces H2O2-induced SHP-2 phosphorylation in rat primary astrocytes and in CRT-MG human astroglioma cells.
Title: Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes.
results support the hypothesis that SHIP2 may play a critical role in the initiation and progression of LSCC and may serve as both a prognostic marker and a potential therapeutic target in patients with LSCC
Title: Prognostic value of elevated SHIP2 expression in laryngeal squamous cell carcinoma.
The function of SHIP2 is different at the plasma membrane where it recognizes PtdIns(3,4,5)P3, and in the nucleus where it may interact with PtdIns(4,5)P2, particularly in speckles.
Title: Evidence of SHIP2 Ser132 phosphorylation, its nuclear localization and stability.
The upregulation of SHIP2 in Zucker rat glomeruli prior to the age of onset of proteinuria suggests a possible role for SHIP2 in the development of podocyte injury.
Title: Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes.
Treatment of HEKs and HCEKs with antago-205 increased SHIP2 levels and impaired the ability of these cells to seal linear scratch wounds compared with untreated or irrelevant-antago treatments
Title: MicroRNA-205 promotes keratinocyte migration via the lipid phosphatase SHIP2.
Data show that SHIP2 localizes to the nucleus and periphery, and has been shown to translocate to the cell membrane following EGF treatment.
Title: Regulation of SHIP2 function through plasma membrane interaction.
LL5beta directs the translocation of filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2.
Title: LL5beta directs the translocation of filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2.
The authors demonstrate that Y483 and Y511 within tandem ITIM-like sequences of Escherichia coli Tir are essential for recruiting human SHIP2, a host inositol phosphatase.
Title: Enteropathogenic Escherichia coli recruits the cellular inositol phosphatase SHIP2 to regulate actin-pedestal formation.
A recent study now shows that two additional tyrosines within Tir recruit the inositol phosphatase SHIP2 to generate a PI(3,4)P2-enriched membrane platform that stabilizes pedestal assembly.
Title: Phosphoinositides influence pathogen surfing: EPEC rights the SHIP.

Submit: New GeneRIF Correction See all (42)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001558.2	NP_005202.2	CSF1R	BIND	PubMed	CSF1R (c-FMS) interacts with INPPL1 (SHIP-2). This interaction was modeled on a demonstrated interaction between CSF1R and INPPL1 from unspecified species.
NP_001558.2	NP_000236.2	MET	BIND	PubMed	MET (c-Met) interacts with INPPL1. This interaction was modeled on a demonstrated interaction between human c-Met and PIK3R1 from an unspecified species.
SHIP2	P00519	ABL1	HPRD	PubMed
SHIP2	P56945	BCAR1	HPRD	PubMed
SHIP2	P22681	CBL	HPRD	PubMed
SHIP2	P07333	CSF1R	HPRD	PubMed
SHIP2	P00533	EGFR	HPRD	PubMed
SHIP2	P31994	FCGR2B	HPRD	PubMed
SHIP2	Q14315	FLNC	HPRD	PubMed
SHIP2	P08581	MET	HPRD	PubMed
SHIP2	P29353	SHC1	HPRD	PubMed
SHIP2	Q9BX66	SORBS1	HPRD	PubMed
SHIP2	O60504	SORBS3	HPRD	PubMed
SHIP2	P12931	SRC	HPRD	PubMed
BioGRID:109848	BioGRID:106543	ABL1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109848	BioGRID:114934	BCAR1	BioGRID	PubMed	Affinity Capture-Western; Far Western; Reconstituted Complex
BioGRID:109848	BioGRID:107315	CBL	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109848	BioGRID:108276	EGFR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109848	BioGRID:108607	FLNC	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:109848	BioGRID:109854	INSR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109848	BioGRID:110391	MET	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109848	BioGRID:112361	SHC1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:109848	BioGRID:115831	SORBS1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:109848	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex

Function	Evidence Code	Pubs
SH2 domain binding	IPI Inferred from Physical Interaction more info	PubMed
SH3 domain binding	IEA Inferred from Electronic Annotation more info
actin binding	IEA Inferred from Electronic Annotation more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
phosphatidylinositol-3,4,5-trisphosphate binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
brain development	IEA Inferred from Electronic Annotation more info
cell adhesion	TAS Traceable Author Statement more info	PubMed
cellular lipid metabolic process	IEA Inferred from Electronic Annotation more info
endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
glucose metabolic process	IEA Inferred from Electronic Annotation more info
inositol trisphosphate metabolic process	IEA Inferred from Electronic Annotation more info
negative regulation of DNA replication	IEA Inferred from Electronic Annotation more info
negative regulation of MAP kinase activity	IEA Inferred from Electronic Annotation more info
negative regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
negative regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
negative regulation of insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
negative regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
negative regulation of platelet-derived growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
phosphatidylinositol phosphorylation	IEA Inferred from Electronic Annotation more info
post-embryonic development	IEA Inferred from Electronic Annotation more info
response to drug	IEA Inferred from Electronic Annotation more info
response to insulin stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
actin cortical patch	IEA Inferred from Electronic Annotation more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
lamellipodium	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

Names: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; SHIP-2; INPPL-1; 51C protein; protein 51C; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2

NP_001558.3

EC 3.1.3.86

EC 3.1.3.n1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023253.1 RefSeqGene

Range

5001..19310

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001567.3 → NP_001558.3 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

Status: REVIEWED

Source sequence(s)

BC140853, BG236320, Y14385

Consensus CDS

CCDS8213.1

UniProtKB/Swiss-Prot

O15357

Related

ENSP00000298229, OTTHUMP00000237158, ENST00000298229, OTTHUMT00000396789

Conserved Domains (3) summary

cd09491
Location:1194 – 1256
Blast Score: 288

SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins

cd09101
Location:424 – 727
Blast Score: 1701

INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins

cd10343
Location:21 – 117
Blast Score: 443

SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p5 Primary Assembly

Range

71935882..71950191

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

68229043..68243351

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AP000593.4 (13639..27963)	None
genomic	CH471076.1	EAW74854.1
		EAW74855.1
mRNA	BC140853.1	AAI40854.1
mRNA	BG236320.1	None
mRNA	L24444.1	AAA50503.1
mRNA	L36818.1	AAA96658.1
mRNA	Y14385.1	CAA74743.1