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INPP5D inositol polyphosphate-5-phosphatase D [ Homo sapiens (human) ]

Gene ID: 3635, updated on 26-May-2016
Official Symbol
INPP5Dprovided by HGNC
Official Full Name
inositol polyphosphate-5-phosphatase Dprovided by HGNC
Primary source
HGNC:HGNC:6079
See related
Ensembl:ENSG00000168918 HPRD:09033; MIM:601582; Vega:OTTHUMG00000133688
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SHIP; SHIP1; SHIP-1; hp51CN; SIP-145; p150Ship
Summary
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Orthologs
Location:
2q37.1
Exon count:
28
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (233059967..233207903)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (233925036..233995881) , (234054795..234116549)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene neuronal guanine nucleotide exchange factor Neighboring gene uncharacterized LOC101928881 Neighboring gene neuraminidase 2 (cytosolic sialidase) Neighboring gene autophagy related 16 like 1 Neighboring gene small Cajal body-specific RNA 5 Neighboring gene small Cajal body-specific RNA 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
NHGRI GWA Catalog
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
NHGRI GWA Catalog
Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of inositol polyphosphate-5-phosphatase, 145kDa (INPP5D) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

  • 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), organism-specific biosystem (from BIOCYC)
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), organism-specific biosystemGeneral Background : MI-HEXAKISPHOSPHATE (phytate, phytic acid) is one of the most prevalent forms of phosphorylated inositols in the cell, with a total concentration of 15-100 μM . It's cellula...
  • 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), conserved biosystem (from BIOCYC)
    1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), conserved biosystemGeneral Background |FRAME: MI-HEXAKISPHOSPHATE| (phytate, phytic acid) is one of the most prevalent forms of phosphorylated inositols in the eukaryotic cell, with a total concentration of 15-100 &m...
  • 3-phosphoinositide degradation, organism-specific biosystem (from BIOCYC)
    3-phosphoinositide degradation, organism-specific biosystem
    3-phosphoinositide degradation
  • 3-phosphoinositide degradation, conserved biosystem (from BIOCYC)
    3-phosphoinositide degradation, conserved biosystem|FRAME: Phosphoinositides "Phosphoinositides"| play a key role in signal transduction in the eukaryotic cell, transmitting signals from the cell surface to modulate intracellular processes. The 3-pho...
  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
  • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
    B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
  • B cell receptor signaling pathway, conserved biosystem (from KEGG)
    B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • D-myo-inositol (1,3,4)-trisphosphate biosynthesis, organism-specific biosystem (from BIOCYC)
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis, organism-specific biosystem: INOSITOL-1-4-5-TRISPHOSPHATE is a secondary messenger molecule used in signal transduction and lipid signaling. It mediates the biological response of a large number of hormones and neurotransmitte...
  • D-myo-inositol (1,3,4)-trisphosphate biosynthesis, conserved biosystem (from BIOCYC)
    D-myo-inositol (1,3,4)-trisphosphate biosynthesis, conserved biosystem|FRAME: INOSITOL-1-4-5-TRISPHOSPHATE| is a secondary messenger molecule used in signal transduction and lipid signaling in eukaryotic cells. It mediates the biological response of a large number of h...
  • Downstream TCR signaling, organism-specific biosystem (from REACTOME)
    Downstream TCR signaling, organism-specific biosystemChanges in gene expression are required for the T cell to gain full proliferative competence and to produce effector cytokines. Three transcription factors in particular have been found to play a key...
  • Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
    Fc epsilon RI signaling pathway, organism-specific biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
  • Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
    Fc epsilon RI signaling pathway, conserved biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
  • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
    Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
  • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
    Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
  • IL-4 signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-4 signaling Pathway, organism-specific biosystemInterleukin-4 belongs to the IL-2 family of cytokines, which includes IL-2, IL-7, IL-9, IL-15 and IL-21. It signals through 2 different receptor complexes; Receptor complex 1 comprises of IL-4 recept...
  • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Inositol phosphate metabolism, organism-specific biosystem (from KEGG)
    Inositol phosphate metabolism, organism-specific biosystem
    Inositol phosphate metabolism
  • Inositol phosphate metabolism, organism-specific biosystem (from REACTOME)
    Inositol phosphate metabolism, organism-specific biosystemInositol phosphates (IPs) are molecules involves in signalling processes in eukaryotes. myo-Inositol consists of a six-carbon cyclic alcohol with an axial 2-hydroxy and five equatorial hydroxyls. M...
  • Inositol phosphate metabolism, conserved biosystem (from KEGG)
    Inositol phosphate metabolism, conserved biosystem
    Inositol phosphate metabolism
  • Interleukin receptor SHC signaling, organism-specific biosystem (from REACTOME)
    Interleukin receptor SHC signaling, organism-specific biosystemPhosphorylation of Shc at three tyrosine residues, 239, 240 (Gotoh et al. 1996) and 317 (Salcini et al. 1994) involves unidentified tyrosine kinases presumed to be part of the activated receptor comp...
  • Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-2 signaling, organism-specific biosystemInterleukin-2 (IL-2) is a cytokine that is produced by T cells in response to antigen stimulation. Originally, IL-2 was discovered because of its potent growth factor activity on activated T cells in...
  • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
    Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemThe Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta...
  • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • PECAM1 interactions, organism-specific biosystem (from REACTOME)
    PECAM1 interactions, organism-specific biosystemPECAM-1/CD31 is a member of the immunoglobulin superfamily (IgSF) and has been implicated to mediate the adhesion and trans-endothelial migration of T-lymphocytes into the vascular wall, T cell activ...
  • PI Metabolism, organism-specific biosystem (from REACTOME)
    PI Metabolism, organism-specific biosystemPhosphatidylinositol (PI), a membrane phospholipid, can be reversibly phosphorylated at the 3, 4, and 5 positions of the inositol ring to generate seven phosphoinositides: phosphatidylinositol 3-phos...
  • Phosphatidylinositol signaling system, organism-specific biosystem (from KEGG)
    Phosphatidylinositol signaling system, organism-specific biosystem
    Phosphatidylinositol signaling system
  • Phosphatidylinositol signaling system, conserved biosystem (from KEGG)
    Phosphatidylinositol signaling system, conserved biosystem
    Phosphatidylinositol signaling system
  • Phospholipid metabolism, organism-specific biosystem (from REACTOME)
    Phospholipid metabolism, organism-specific biosystemPhospholipids contain a polar head group and two long-chain fatty acyl moieties, one of which is generally unsaturated. The head group is a glycerol or serine phosphate attached to a polar group such...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Synthesis of IP3 and IP4 in the cytosol, organism-specific biosystem (from REACTOME)
    Synthesis of IP3 and IP4 in the cytosol, organism-specific biosystemAn array of inositol trisphosphate (IP3) and tetrakisphosphate (IP4) molecules are synthesised by the action of various kinases and phosphatases in the cytosol (Irvine & Schell 2001, Bunney & Katan 2...
  • Synthesis of PIPs at the plasma membrane, organism-specific biosystem (from REACTOME)
    Synthesis of PIPs at the plasma membrane, organism-specific biosystemAt the plasma membrane, subsequent phosphorylation of phosphatidylinositol 4-phosphate (PI4P) produces phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (...
  • TCR signaling, organism-specific biosystem (from REACTOME)
    TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
  • superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism, organism-specific biosystem (from BIOCYC)
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism, organism-specific biosystem
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
  • superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism, conserved biosystem (from BIOCYC)
    superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism, conserved biosystem|FRAME: INOSITOL-1-4-5-TRISPHOSPHATE| is a secondary messenger molecule used in signal transduction and lipid signaling in eukaryotic cells. It mediates the biological response of a large number of h...
  • superpathway of inositol phosphate compounds, organism-specific biosystem (from BIOCYC)
    superpathway of inositol phosphate compounds, organism-specific biosystem
    superpathway of inositol phosphate compounds
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC104855, MGC142140, MGC142142

Gene Ontology Provided by GOA

Function Evidence Code Pubs
PTB domain binding IEA
Inferred from Electronic Annotation
more info
 
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity TAS
Traceable Author Statement
more info
 
inositol-polyphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity TAS
Traceable Author Statement
more info
 
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
determination of adult lifespan IEA
Inferred from Electronic Annotation
more info
 
immunoglobulin mediated immune response IEA
Inferred from Electronic Annotation
more info
 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
negative regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of bone resorption IEA
Inferred from Electronic Annotation
more info
 
negative regulation of immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-6 biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of monocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neutrophil differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
phosphate-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Names
SH2 domain-containing inositol 5'-phosphatase 1
inositol polyphosphate-5-phosphatase, 145kD
inositol polyphosphate-5-phosphatase, 145kDa
signaling inositol polyphosphate 5 phosphatase SIP-145
signaling inositol polyphosphate phosphatase SHIP II
NP_001017915.1
NP_005532.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033988.1 RefSeqGene

    Range
    5001..152937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001017915.2NP_001017915.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform a

    See identical proteins and their annotated locations for NP_001017915.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AW503130, BC099920, U53470, U57650
    Consensus CDS
    CCDS74672.1
    UniProtKB/Swiss-Prot
    Q92835
    Related
    ENSP00000405338, OTTHUMP00000165072, ENST00000445964, OTTHUMT00000257935
    Conserved Domains (3) summary
    cd09100
    Location:404710
    INPP5c_SHIP1-INPP5D; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins
    cd10343
    Location:1102
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
    cl12038
    Location:9761052
    ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...
  2. NM_005541.4NP_005532.2  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform b

    See identical proteins and their annotated locations for NP_005532.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a.
    Source sequence(s)
    AW503130, BC099920, U57650, X98429
    Consensus CDS
    CCDS77543.1
    UniProtKB/Swiss-Prot
    Q92835
    Related
    ENSP00000352575, OTTHUMP00000165069, ENST00000359570, OTTHUMT00000257930
    Conserved Domains (3) summary
    cd09100
    Location:403709
    INPP5c_SHIP1-INPP5D; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins
    cd10343
    Location:1102
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
    cl12038
    Location:9751051
    ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    233059967..233207903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511128.1XP_011509430.1  

    See identical proteins and their annotated locations for XP_011509430.1

    Conserved Domains (2) summary
    cd09100
    Location:404710
    INPP5c_SHIP1-INPP5D; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins
    cd10343
    Location:1102
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
  2. XM_011511129.1XP_011509431.1  

    See identical proteins and their annotated locations for XP_011509431.1

    Related
    ENSP00000397421, OTTHUMP00000203442, ENST00000415617, OTTHUMT00000330246
    Conserved Domains (2) summary
    cd09100
    Location:144450
    INPP5c_SHIP1-INPP5D; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins
    cl12038
    Location:716792
    ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

Reference GRCh38.p2 PATCHES

Genomic

  1. NW_011332690.1 Reference GRCh38.p2 PATCHES

    Range
    5305..153241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011548851.1XP_011547153.1  

    See identical proteins and their annotated locations for XP_011547153.1

    Conserved Domains (2) summary
    cd09100
    Location:404710
    INPP5c_SHIP1-INPP5D; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins
    cd10343
    Location:1102
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
  2. XM_011548852.1XP_011547154.1  

    See identical proteins and their annotated locations for XP_011547154.1

    Conserved Domains (2) summary
    cd09100
    Location:144450
    INPP5c_SHIP1-INPP5D; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins
    cl12038
    Location:716792
    ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    233930442..234000981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. NC_018913.2 Alternate CHM1_1.1

    Range
    234060594..234122681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)