INPP5A inositol polyphosphate-5-phosphatase, 40kDa [Homo sapiens] - Gene

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Summary

Official Symbol: INPP5Aprovided by HGNC
Official Full Name: inositol polyphosphate-5-phosphatase, 40kDaprovided by HGNC
Primary source: HGNC:6076
Locus tag: RP11-288G11.1
See related: Ensembl:ENSG00000068383; HPRD:02521; MIM:600106; Vega:OTTHUMG00000019293
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: 5PTASE; MGC116947; MGC116949; DKFZp434A1721
Summary: The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 10q26.3

Sequence :: Chromosome: 10; NC_000010.10 (134351353..134596984)

See INPP5A in Epigenomics, MapViewer

Chromosome 10 - NC_000010.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NPP5Amay play a role in development and progression of cutaneous squamous cell carcinoma tumors
Title: Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinoma.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q14642	P08567	PLEK	HPRD	PubMed
Q14642	P63104	YWHAZ	HPRD	PubMed
BioGRID:109844	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109844	BioGRID:113366	YWHAZ	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
PH domain binding	IPI Inferred from Physical Interaction more info	PubMed
hydrolase activity	IEA Inferred from Electronic Annotation more info
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
inositol-1,4,5-trisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
inositol-polyphosphate 5-phosphatase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
cell communication	NAS Non-traceable Author Statement more info
phosphatidylinositol phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

Preferred Names: type I inositol 1,4,5-trisphosphate 5-phosphatase

Names: type I inositol 1,4,5-trisphosphate 5-phosphatase; InsP3 5-phosphatase; CTCL tumor antigen HD-CL-02; 43 kDa inositol polyphosphate 5-phophatase; inositol trisphosphate-5-phosphatase, 40kD; type I inositol-1,4,5-trisphosphate 5-phophatase; type I inositol-1,4,5-trisphosphate 5-phosphatase

NP_005530.3

EC 3.1.3.56

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005539.3 → NP_005530.3 type I inositol 1,4,5-trisphosphate 5-phosphatase

Status: REVIEWED

Source sequence(s)

AF273055, AL392043, BC096280

Consensus CDS

CCDS7669.2

UniProtKB/Swiss-Prot

Q14642

UniProtKB/TrEMBL

Q8N6C1

Related

ENSP00000357583, OTTHUMP00000020775, ENST00000368594, OTTHUMT00000051085

Conserved Domains (1) summary

cd09092
Location:10 – 394
Blast Score: 1896

INPP5A; Type I inositol polyphosphate 5-phosphatase I

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000010.10 Reference GRCh37.p5 Primary Assembly

Range

134351353..134596984

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000142.1 Alternate HuRef

Range

127973351..128148455

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF184215.1	AAK13252.1
genomic	AL356603.11	CAI40940.1
		CAI40941.1
		CAI40942.1
		CAI40944.1
genomic	AL356603.11	CAI40940.1
		CAI40941.1
		CAI40942.1
		CAI40944.1
genomic	AL392043.21	CAI39941.1
		CAI39942.1
		CAI39944.1
		CAI39945.1
		CAI39946.1
		CAI39947.1
genomic	AL392043.21	CAI39941.1
		CAI39942.1
		CAI39944.1
		CAI39945.1
		CAI39946.1
		CAI39947.1
genomic	AL451069.34	CAI14120.1
		CAI14121.1
		CAI14123.1
genomic	CH471211.2	EAW61306.1
		EAW61307.1
mRNA	AF273055.1	AAM44458.1
mRNA	BC052265.1	AAH52265.1
mRNA	BC062300.1	AAH62300.1
mRNA	BC096280.2	AAH96280.1
mRNA	BC096281.2	AAH96281.1
mRNA	BC117515.1	AAI17516.1
mRNA	BM467443.1	None
mRNA	BM666428.1	None
mRNA	CB960907.1	None
mRNA	X77567.1	CAA54676.1
mRNA	Z31695.1	CAA83500.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q14642.1	GenPept	UniProtKB/Swiss-Prot:Q14642
Q149S6	GenPept	UniProtKB/TrEMBL:Q149S6
Q4VAR4	GenPept	UniProtKB/TrEMBL:Q4VAR4
Q5T1B5	GenPept	UniProtKB/TrEMBL:Q5T1B5
Q86V83	GenPept	UniProtKB/TrEMBL:Q86V83
Q8N6C1	GenPept	UniProtKB/TrEMBL:Q8N6C1
Q9C055	GenPept	UniProtKB/TrEMBL:Q9C055