skpB [Drosophila melanogaster] - Gene

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Summary

Official Symbol: skpBprovided by Flybase
Primary source: FLYBASE:FBgn0026176
Locus tag: Dmel_CG8881
Gene type: protein coding
RNA name: skpB
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8881; Dmel\CG8881; dskpB; Skp

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Genomic context

Location :: 48E2-48E2

Sequence :: Chromosome: 2R; NT_033778.3 (8026800..8027567, complement)

See skpB in Epigenomics, MapViewer

Chromosome 2R - NT_033778.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:62080	BioGRID:67903	CG11120	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:67185	CG14317	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:60644	CG14937	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:59148	CG15043	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:63098	CG15676	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:72813	CG18745	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:68340	CG2010	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:61742	CG34350	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:78265	CG40282	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:66989	CG4221	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:64446	CG4911	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:68226	CG5003	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:60446	CG5731	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:60628	CG6488	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:63149	CG6758	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:65672	CG7148	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:61716	CG8272	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:61296	CG9316	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:60055	CG9527	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:68567	CycG	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:68699	E23	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:62223	Fsn	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:64301	Hn	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:59479	MED15	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:64459	PGRP-LA	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:58962	Pp2B-14D	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:65211	Rbp6	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:60110	Rca1	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:59992	Vm26Ab	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:59522	aru	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:67943	dan	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:68740	e(r)	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:61996	fbl6	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:61396	gus	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:60111	l(2)k09022	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:63933	ntc	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:68684	ras	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:67475	slmb	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:68433	spn-A	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:71024	tws	BioGRID	PubMed	Two-hybrid
BioGRID:62080	BioGRID:64244	unc-13-4A	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the skpB gene: The skpB gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, and rice.

Pathways from BioSystems

APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Circadian Clock, organism-specific biosystem (from REACTOME)
Circadian Clock, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Circadian rhythm - mammal, organism-specific biosystem (from KEGG)
Circadian rhythm - mammal, organism-specific biosystem
Circadian rhythm - mammal
Circadian rhythm - mammal, conserved biosystem (from KEGG)
Circadian rhythm - mammal, conserved biosystem
Circadian rhythm - mammal
Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
Degradation of beta-catenin by the destruction complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
Regulation of mitotic cell cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SCF-BTRC complex, organism-specific biosystem (from KEGG)
SCF-BTRC complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
SCF-FBW7 complex, organism-specific biosystem (from KEGG)
SCF-FBW7 complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
SCF-SKP2 complex, organism-specific biosystem (from KEGG)
SCF-SKP2 complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
SCF-beta-TrCP mediated degradation of Emi1, organism-specific biosystem (from REACTOME)
SCF-beta-TrCP mediated degradation of Emi1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Wnt, organism-specific biosystem (from REACTOME)
Signaling by Wnt, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
TGF-beta signaling pathway, conserved biosystem (from KEGG)
TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
Wnt signaling pathway, organism-specific biosystem (from KEGG)
Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Wnt signaling pathway, conserved biosystem (from KEGG)
Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

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General protein information

Preferred Names: CG8881 gene product from transcript CG8881-RA

Names: CG8881-PA; skpB; skpB-PA

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.3

Range

8026800..8027567, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_136885.3 → NP_610729.1 skpB [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q7KJ69

Related

FBpp0087127, FBtr0088020

Conserved Domains (3) summary

COG5201
Location:1 – 161
Blast Score: 353

SKP1; SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]

pfam01466
Location:83 – 160
Blast Score: 341

Skp1; Skp1 family, dimerisation domain

cl02518
Location:1 – 110
Blast Score: 290

BTB; BTB/POZ domain