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Drep3 DNA fragmentation factor-related protein 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36292, updated on 4-Apr-2024

Summary

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Official Symbol
Drep3provided by FlyBase
Official Full Name
DNA fragmentation factor-related protein 3provided by FlyBase
Primary source
FLYBASE:FBgn0028407
Locus tag
Dmel_CG8364
See related
AllianceGenome:FB:FBgn0028407
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:AT08574; CG13187; CG8364; Dmel\CG8364; drep-3; Drep-3; DREP-3; drep3; DREP3; Rep3
Summary
Predicted to be involved in regulation of apoptotic process. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 5 and obesity. Orthologous to human CIDEA (cell death inducing DFFA like effector a); CIDEB (cell death inducing DFFA like effector b); and CIDEC (cell death inducing DFFA like effector c). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Drep3 in Genome Data Viewer
Location:
48D8-48D8; 2-65 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12055089..12062866)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7942594..7950371)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene DNA fragmentation factor-related protein 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Helical filament structure of the DREP3 CIDE domain reveals a unified mechanism of CIDE-domain assembly. Lee SY, et al. Acta Crystallogr D Struct Biol, 2021 Dec 1. PMID 34866610, Free PMC Article
  2. Crystallization and preliminary X-ray crystallographic studies of the CIDE-domain complex between Drep2 and Drep3 from Drosophila melanogaster. Park OK, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Apr 1. PMID 21505240, Free PMC Article
  3. Molecular basis of apoptotic DNA fragmentation by DFF40. Ha HJ, et al. Cell Death Dis, 2022 Mar 2. PMID 35236824, Free PMC Article
  4. Interaction mode of CIDE family proteins in fly: DREP1 and DREP3 acidic surfaces interact with DREP2 and DREP4 basic surfaces. Kim CM, et al. PLoS One, 2017. PMID 29240809, Free PMC Article
  5. In vitro analysis of the complete CIDE domain interactions of the Drep system in fly. Lee SM, et al. Apoptosis, 2014 Mar. PMID 24233238

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that the basic surface side of Drep2 CIDE is involved in the interaction with the acidic surface side of Drep1 CIDE and Drep3 CIDE.
    Title: General interaction mode of CIDE:CIDE complex revealed by a mutation study of the Drep2 CIDE domain.
  2. Drep2 is a novel nuclease whose activity is inhibited by Drep3 through a tight interaction with the CIDE domain.
    Title: Dual apoptotic DNA fragmentation system in the fly: Drep2 is a novel nuclease of which activity is inhibited by Drep3.
  3. CIDE domains of Drep2 and Drep3 were purified in Escherichia coli, after which they formed a stable complex in vitro and were crystallized by the hanging-drop vapour-diffusion method. X-ray diffraction data were collected to a resolution of 5.8 A.
    Title: Crystallization and preliminary X-ray crystallographic studies of the CIDE-domain complex between Drep2 and Drep3 from Drosophila melanogaster.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA fragmentation factor-related protein 3
Names
CG8364-PA
CG8364-PB
Drep3-PA
Drep3-PB
Rep3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12055089..12062866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136879.3 → NP_610723.2  DNA fragmentation factor-related protein 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610723.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E9B7, Q9U786
    Related
    FBpp0087088
    Conserved Domains (1) summary
    cd01615
    Location:119 → 192
    CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...

  2. NM_136878.3 → NP_610722.2  DNA fragmentation factor-related protein 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610722.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E9B7, Q9U786
    Related
    FBpp0087087
    Conserved Domains (1) summary
    cd01615
    Location:119 → 192
    CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0E9B7 Q0E9B7
Q8T4H5 Q8T4H5
Q9U786 Q9U786

Gene LinkOut

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