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Mbip MAP3K12 binding inhibitory protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362740, updated on 13-Apr-2024

Summary

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Official Symbol
Mbipprovided by RGD
Official Full Name
MAP3K12 binding inhibitory protein 1provided by RGD
Primary source
RGD:1306310
See related
Ensembl:ENSRNOG00000008610 AllianceGenome:RGD:1306310
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and protein kinase inhibitor activity. Predicted to be involved in histone H3 acetylation; positive regulation of JNK cascade; and positive regulation of gene expression. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of ATAC complex. Predicted to be active in cytosol. Orthologous to human MBIP (MAP3K12 binding inhibitory protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 204.7), Thymus (RPKM 62.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q23
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (79543223..79560476, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (73808133..73825394, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (77226439..77243696, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351238 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120103538 Neighboring gene uncharacterized LOC134479387 Neighboring gene uncharacterized LOC134479388 Neighboring gene uncharacterized LOC102551688

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Guelman S, et al. Mol Cell Biol, 2009 Mar. PMID 19103755, Free PMC Article
  2. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. Wang YL, et al. J Biol Chem, 2008 Dec 5. PMID 18838386, Free PMC Article
  3. ATAC-king the complexity of SAGA during evolution. Spedale G, et al. Genes Dev, 2012 Mar 15. PMID 22426530, Free PMC Article
  4. ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes. Krebs AR, et al. EMBO Rep, 2010 Jul. PMID 20508642, Free PMC Article
  5. An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell division ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of tubulin deacetylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
MAP3K12-binding inhibitory protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108712.3 → NP_001102182.2  MAP3K12-binding inhibitory protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    B2RZ10
    Related
    ENSRNOP00000011419.6, ENSRNOT00000011419.6

  2. NM_001399696.1 → NP_001386625.1  MAP3K12-binding inhibitory protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6HBN3

  3. NM_001399697.1 → NP_001386626.1  MAP3K12-binding inhibitory protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  4. NM_001399698.1 → NP_001386627.1  MAP3K12-binding inhibitory protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    79543223..79560476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262114.1 → XP_063118184.1  MAP3K12-binding inhibitory protein 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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