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Mthfr methylenetetrahydrofolate reductase (NAD(P)H) [ Rattus norvegicus (Norway rat) ]

Gene ID: 362657, updated on 26-May-2016
Official Symbol
Mthfrprovided by RGD
Official Full Name
methylenetetrahydrofolate reductase (NAD(P)H)provided by RGD
Primary source
RGD:1309952
See related
Ensembl:ENSRNOG00000008553
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
converts 5,10 methylenetetrahydrofolate to 5-methyltetrahydrofolate; mutations in human may be associated with hyperhomocysteinaemia, and a risk factor for spina bifida in women [RGD, Feb 2006]
Orthologs
Location:
5q36
Exon count:
15
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (164844653..164864360)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (168502556..168522350)

Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene natriuretic peptide A Neighboring gene chloride voltage-gated channel 6 Neighboring gene NHP2-like protein 1-like Neighboring gene uncharacterized LOC102551309

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NADP binding IDA
Inferred from Direct Assay
more info
PubMed 
flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
methylenetetrahydrofolate reductase (NAD(P)H) activity IDA
Inferred from Direct Assay
more info
PubMed 
methylenetetrahydrofolate reductase (NAD(P)H) activity ISO
Inferred from Sequence Orthology
more info
 
modified amino acid binding IEA
Inferred from Electronic Annotation
more info
 
modified amino acid binding ISO
Inferred from Sequence Orthology
more info
 
protein complex binding IEA
Inferred from Electronic Annotation
more info
 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
S-adenosylmethionine metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
heterochromatin maintenance IEA
Inferred from Electronic Annotation
more info
 
heterochromatin maintenance ISO
Inferred from Sequence Orthology
more info
 
homocysteine metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
homocysteine metabolic process ISO
Inferred from Sequence Orthology
more info
 
methionine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
methionine metabolic process IEA
Inferred from Electronic Annotation
more info
 
methionine metabolic process ISO
Inferred from Sequence Orthology
more info
 
one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
regulation of histone methylation IEA
Inferred from Electronic Annotation
more info
 
regulation of histone methylation ISO
Inferred from Sequence Orthology
more info
 
response to amino acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to folic acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin B2 IEP
Inferred from Expression Pattern
more info
PubMed 
tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 
tetrahydrofolate interconversion ISO
Inferred from Sequence Orthology
more info
 
tetrahydrofolate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
methylenetetrahydrofolate reductase
Names
5,10-methylenetetrahydrofolate reductase (NADPH)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

    Range
    164844653..164864360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239414.2XP_006239476.1  

    See identical proteins and their annotated locations for XP_006239476.1

    Conserved Domains (1) summary
    cd00537
    Location:65341
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
  2. XM_006239416.1XP_006239478.1  

    See identical proteins and their annotated locations for XP_006239478.1

    Conserved Domains (1) summary
    cd00537
    Location:59335
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
  3. XM_006239417.1XP_006239479.1  

    See identical proteins and their annotated locations for XP_006239479.1

    Conserved Domains (1) summary
    cd00537
    Location:59335
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
  4. XM_342975.6XP_342976.3  

    See identical proteins and their annotated locations for XP_342976.3

    UniProtKB/TrEMBL
    D4A7E8
    Related
    ENSRNOP00000011384, ENSRNOT00000011384
    Conserved Domains (1) summary
    cd00537
    Location:100376
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
  5. XM_006239413.2XP_006239475.1  

    See identical proteins and their annotated locations for XP_006239475.1

    Conserved Domains (1) summary
    cd00537
    Location:99375
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
  6. XM_006239418.1XP_006239480.1  

    See identical proteins and their annotated locations for XP_006239480.1

    Conserved Domains (1) summary
    cd00537
    Location:1261
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

Alternate Rn_Celera

Genomic

  1. AC_000073.1 Alternate Rn_Celera

    Range
    156747035..156766742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006225612.2XP_006225674.1  

    See identical proteins and their annotated locations for XP_006225674.1

    Conserved Domains (1) summary
    cd00537
    Location:65341
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
  2. XM_006225614.1XP_006225676.1  

    See identical proteins and their annotated locations for XP_006225676.1

    Conserved Domains (1) summary
    cd00537
    Location:59335
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
  3. XM_006225615.1XP_006225677.1  

    See identical proteins and their annotated locations for XP_006225677.1

    Conserved Domains (1) summary
    cd00537
    Location:59335
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
  4. XM_001074061.5XP_001074061.2  

    See identical proteins and their annotated locations for XP_001074061.2

    UniProtKB/TrEMBL
    D4A7E8
    Conserved Domains (1) summary
    cd00537
    Location:100376
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
  5. XM_006225611.2XP_006225673.1  

    See identical proteins and their annotated locations for XP_006225673.1

    Conserved Domains (1) summary
    cd00537
    Location:99375
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
  6. XM_006225616.1XP_006225678.1  

    See identical proteins and their annotated locations for XP_006225678.1

    Conserved Domains (1) summary
    cd00537
    Location:1261
    MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...