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    Sln Silnoon [ Drosophila melanogaster ]

    Gene ID: 36263, updated on 10-May-2012
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    Summary

    Official Symbol
    Slnprovided by Flybase
    Official Full Name
    Silnoonprovided by Flybase
    Primary source
    FLYBASE:FBgn0033657
    Locus tag
    Dmel_CG8271
    Gene type
    protein coding
    RNA name
    silnoon
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8271; Dmel\CG8271
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    Genomic context

    Location :
    48C4-48C5
    Sequence :
    Chromosome: 2R; NT_033778.3 (7732831..7739829)
    See Sln in Epigenomics, MapViewer

    Chromosome 2R - NT_033778.3Genomic Context describing neighboring genes Neighboring gene CG34229 gene product from transcript CG34229-RA Neighboring gene site-2 protease Neighboring gene CG43190 gene product from transcript CG43190-RA Neighboring gene Megator Neighboring gene CG34230 gene product from transcript CG34230-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. FGF ligands in Drosophila have distinct activities required to support cell migration and differentiation. Kadam S, et al. Development, 2009 Mar. PMID 19158183.
    2. Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster. Matthews KA, et al. Genetics, 2009 Jan. PMID 19015545.
    3. LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster. Jang C, et al. J Cell Biol, 2008 Oct 6. PMID 18838551.
    4. Identification and characterization of a juvenile hormone response element and its binding proteins. Li Y, et al. J Biol Chem, 2007 Dec 28. PMID 17956872.
    5. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.

    See all (15) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Silnoon (Sln), product of the CG8271 gene, is a monocarboxylate transporter that mediates transport of monocarboxylates such as butyrate and lactate, is an important downstream target of LKB1, which controls both epithelial polarity and cell death.
      Title: LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:62049 BioGRID:66123 CG2678    BioGRID  PubMed Two-hybrid 
    BioGRID:62049 BioGRID:58854 CG8128    BioGRID  PubMed Two-hybrid 
    BioGRID:62049 BioGRID:69380 DNApol-alpha60    BioGRID  PubMed Two-hybrid 
    BioGRID:62049 BioGRID:68286 Doa    BioGRID  PubMed Two-hybrid 
    BioGRID:62049 BioGRID:77702 par-1    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the Sln gene: The Sln gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, K.lactis, and .

    Pathways from BioSystems

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    monocarboxylic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    secondary active monocarboxylate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    CG8271 gene product from transcript CG8271-RA
    Names
    CG8271-PA
    Sln-PA
    silnoon
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.3

      Range
      7732831..7739829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136862.1 → NP_610706.1  silnoon [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U154
      Related
      FBpp0087139, FBtr0088032
      Conserved Domains (1) summary
      cd06174
      Location:656 – 827
      Blast Score: 231
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE013599.4 AAF58616.2
    mRNA BT016038.1 AAV36923.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V623.1 GenPept
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    Additional Links

    Gene LinkOut

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