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Sod3 Superoxide dismutase 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36232, updated on 4-Apr-2024

Summary

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Official Symbol
Sod3provided by FlyBase
Official Full Name
Superoxide dismutase 3provided by FlyBase
Primary source
FLYBASE:FBgn0033631
Locus tag
Dmel_CG9027
See related
AllianceGenome:FB:FBgn0033631
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13200; CG9027; CT25938; Dmel/CG9027; Dmel\CG9027; dSod3; dSOD3; sod-3; SOD3
Summary
Enables superoxide dismutase activity. Involved in UV protection and removal of superoxide radicals. Located in extracellular space. Is expressed in anterior midgut primordium; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1) and SOD3 (superoxide dismutase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Sod3 in Genome Data Viewer
Location:
47F7-47F8; 2-64 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11380347..11384114, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7267852..7271619, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tetraspanin 47F Neighboring gene sprite Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Threonine-TGT 2-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular phylogenetic evidence for an extracellular Cu Zn superoxide dismutase gene in insects. Parker JD, et al. Insect Mol Biol, 2004 Dec. PMID 15606807
  2. Cloning and expression analysis of Drosophila extracellular Cu Zn superoxide dismutase. Blackney MJ, et al. Biosci Rep, 2014 Dec 23. PMID 25339624, Free PMC Article
  3. Natural variation of gene models in Drosophila melanogaster. Kurmangaliyev YZ, et al. BMC Genomics, 2015 Mar 17. PMID 25888292, Free PMC Article
  4. Superoxide dismutase evolution and life span regulation. Landis GN, et al. Mech Ageing Dev, 2005 Mar. PMID 15664623
  5. Distribution and diversity of ROS-generating enzymes across the animal kingdom, with a focus on sponges (Porifera). Hewitt OH, et al. BMC Biol, 2022 Sep 30. PMID 36175868, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show higher levels of expression of Sod3 (extracellular Cu Zn superoxide dismutase) in females.
    Title: Cloning and expression analysis of Drosophila extracellular Cu Zn superoxide dismutase.
  2. found that dSod3 not only retains SOD activity but also properties of secreted proteins, as do other SOD3s
    Title: Identification of Drosophila SOD3 and its protective role against phototoxic damage to cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables superoxide dismutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables superoxide dismutase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables superoxide dismutase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in UV protection IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in removal of superoxide radicals IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in superoxide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
superoxide dismutase 3
Names
CG9027-PA
CG9027-PB
CG9027-PD
CG9027-PE
CG9027-PF
Sod3-PA
Sod3-PB
Sod3-PD
Sod3-PE
Sod3-PF
NP_001033939.2
NP_001036536.1
NP_001303344.1
NP_610682.2
NP_725046.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    11380347..11384114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001043071.2 → NP_001036536.1  superoxide dismutase 3, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036536.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JR71
    Conserved Domains (1) summary
    pfam00080
    Location:42 → 178
    Sod_Cu; Copper/zinc superoxide dismutase (SODC)

  2. NM_001038850.2 → NP_001033939.2  superoxide dismutase 3, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033939.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z8K9
    Conserved Domains (1) summary
    pfam00080
    Location:43 → 178
    Sod_Cu; Copper/zinc superoxide dismutase (SODC)

  3. NM_001316415.1 → NP_001303344.1  superoxide dismutase 3, isoform F [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D8FT33, Q0E9C3, Q5U195, Q7JR71, Q95T42
    Conserved Domains (1) summary
    pfam00080
    Location:38 → 178
    Sod_Cu; Copper/zinc superoxide dismutase (SODC)

  4. NM_165829.3 → NP_725046.2  superoxide dismutase 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725046.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D8FT33, Q0E9C3, Q5U195, Q7JR71, Q95T42
    Related
    FBpp0088877
    Conserved Domains (1) summary
    pfam00080
    Location:38 → 178
    Sod_Cu; Copper/zinc superoxide dismutase (SODC)

  5. NM_136838.3 → NP_610682.2  superoxide dismutase 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610682.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D8FT33, Q0E9C3, Q5U195, Q7JR71, Q95T42
    Related
    FBpp0088878
    Conserved Domains (1) summary
    pfam00080
    Location:38 → 178
    Sod_Cu; Copper/zinc superoxide dismutase (SODC)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z8K9 A1Z8K9
Q7JR71.1 Q7JR71

Gene LinkOut

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