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INHA inhibin alpha [ Homo sapiens (human) ]

Gene ID: 3623, updated on 8-May-2016
Official Symbol
INHAprovided by HGNC
Official Full Name
inhibin alphaprovided by HGNC
Primary source
HGNC:HGNC:6065
See related
Ensembl:ENSG00000123999 HPRD:00933; MIM:147380; Vega:OTTHUMG00000059237
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the TGF-beta superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mice in which a similar gene has been ablated exhibit sex cord-stromal tumors and symptoms that mimic the human cancer cachexia syndrome. [provided by RefSeq, Jan 2016]
Orthologs
Location:
2q35
Exon count:
2
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (219572232..219575713)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220436954..220440435)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 198 Neighboring gene microRNA 3132 Neighboring gene obscurin-like 1 Neighboring gene serine/threonine kinase 11 interacting protein Neighboring gene solute carrier family 4 member 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Glycoprotein hormones, organism-specific biosystem (from REACTOME)
    Glycoprotein hormones, organism-specific biosystemMore complex protein hormones have carbohydrate side chains and are called glycoprotein hormones. Hormones in this class are Follicle-stimulating hormone (FSH; follitropin), Luteinizing hormone (LH),...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
    Ovarian Infertility Genes, organism-specific biosystemOvarian bottleneck genes associated with infertility. A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility ph...
  • Peptide hormone biosynthesis, organism-specific biosystem (from REACTOME)
    Peptide hormone biosynthesis, organism-specific biosystemPeptide hormones are peptides that are secreted directly into the blood stream (endocrine hormones). They are synthesized as precursors that require proteolytic processing (not discussed here) to gen...
  • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
    Peptide hormone metabolism, organism-specific biosystemPeptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity TAS
Traceable Author Statement
more info
PubMed 
growth factor activity TAS
Traceable Author Statement
more info
PubMed 
hormone activity TAS
Traceable Author Statement
more info
PubMed 
inhibin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
 
cell differentiation TAS
Traceable Author Statement
more info
PubMed 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
erythrocyte differentiation NAS
Non-traceable Author Statement
more info
PubMed 
hemoglobin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of B cell differentiation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell cycle TAS
Traceable Author Statement
more info
PubMed 
negative regulation of follicle-stimulating hormone secretion NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of interferon-gamma biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of macrophage differentiation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of phosphorylation TAS
Traceable Author Statement
more info
PubMed 
nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
ovarian follicle development NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of follicle-stimulating hormone secretion TAS
Traceable Author Statement
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
response to external stimulus TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
skeletal system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
inhibin A complex IDA
Inferred from Direct Assay
more info
PubMed 
inhibin B complex IEA
Inferred from Electronic Annotation
more info
 
inhibin-betaglycan-ActRII complex IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
 
photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
inhibin alpha chain
Names
A-inhibin subunit

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002191.3NP_002182.1  inhibin alpha chain preproprotein

    See identical proteins and their annotated locations for NP_002182.1

    Status: REVIEWED

    Source sequence(s)
    AW025787, BC006391, M13981
    Consensus CDS
    CCDS2444.1
    UniProtKB/Swiss-Prot
    P05111
    Related
    ENSP00000243786, OTTHUMP00000065425, ENST00000243786, OTTHUMT00000131425
    Conserved Domains (1) summary
    smart00204
    Location:262366
    TGFB; Transforming growth factor-beta (TGF-beta) family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    219572232..219575713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    220442773..220446254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)