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Phactr3 phosphatase and actin regulator 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362284, updated on 13-Apr-2024

Summary

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Symbol
Phactr3provided by RGD
Full Name
phosphatase and actin regulator 3provided by RGD
Primary source
RGD:1303029
See related
Ensembl:ENSRNOG00000057996 AllianceGenome:RGD:1303029
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Scapin1; scapinin
Summary
Enables actin binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be located in nucleoplasm. Orthologous to human PHACTR3 (phosphatase and actin regulator 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 289.5) See more
Orthologs
human mouse all
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Genomic context

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See Phactr3 in Genome Data Viewer
Location:
3q43
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (185582134..185801404)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (165205247..165423692)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (173798542..173871386)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7, pseudogene 15 Neighboring gene ribosomal protein L7a, pseudogene 1 Neighboring gene 60S ribosomal protein L19-like Neighboring gene synaptonemal complex protein 2 Neighboring gene aldo-keto reductase family 1, member B1 (aldose reductase), pseudogene 3 Neighboring gene protein phosphatase 1, regulatory subunit 3D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain. Miyata T, et al. Biochem Biophys Res Commun, 2020 Jul 23. PMID 32423795
  2. Scapinin-induced inhibition of axon elongation is attenuated by phosphorylation and translocation to the cytoplasm. Farghaian H, et al. J Biol Chem, 2011 Jun 3. PMID 21487013, Free PMC Article
  3. Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure. Sagara J, et al. J Biol Chem, 2003 Nov 14. PMID 12925532
  4. Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins. Allen PB, et al. Proc Natl Acad Sci U S A, 2004 May 4. PMID 15107502, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain.
    Title: Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain.
  2. Because its expression is highest in relatively plastic regions of the adult brain (cortex, hippocampus), scapinin is a new regulator of neurite outgrowth and neuroplasticity in the brain.
    Title: Scapinin-induced inhibition of axon elongation is attenuated by phosphorylation and translocation to the cytoplasm.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase inhibitor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphatase and actin regulator 3
Names
scaffold-associated PP1-inhibiting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214459.3 → NP_999624.1  phosphatase and actin regulator 3

    See identical proteins and their annotated locations for NP_999624.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q6RFY2
    UniProtKB/TrEMBL
    A0A0G2K018, A6KMF0
    Related
    ENSRNOP00000071267.2, ENSRNOT00000083726.2
    Conserved Domains (2) summary
    smart00707
    Location:398 → 422
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam17380
    Location:352 → 505
    DUF5401; Family of unknown function (DUF5401)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    185582134..185801404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284233.1 → XP_063140303.1  phosphatase and actin regulator 3 isoform X3

    UniProtKB/Swiss-Prot
    Q6RFY2
    UniProtKB/TrEMBL
    A6KMF0

  2. XM_039105551.2 → XP_038961479.1  phosphatase and actin regulator 3 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K018, A0A0G2K0S0
    Related
    ENSRNOP00000071558.2
    Conserved Domains (2) summary
    smart00707
    Location:434 → 458
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam17380
    Location:388 → 541
    DUF5401; Family of unknown function (DUF5401)

  3. XM_039105550.2 → XP_038961478.1  phosphatase and actin regulator 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K018, A0A8I6G2L2
    Related
    ENSRNOP00000078324.1
    Conserved Domains (2) summary
    smart00707
    Location:439 → 463
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam17380
    Location:393 → 546
    DUF5401; Family of unknown function (DUF5401)

  4. XM_039105552.2 → XP_038961480.1  phosphatase and actin regulator 3 isoform X3

    UniProtKB/Swiss-Prot
    Q6RFY2
    UniProtKB/TrEMBL
    A0A0G2K018, A6KMF0
    Conserved Domains (2) summary
    smart00707
    Location:398 → 422
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam17380
    Location:352 → 505
    DUF5401; Family of unknown function (DUF5401)

  5. XM_039105553.2 → XP_038961481.1  phosphatase and actin regulator 3 isoform X3

    UniProtKB/Swiss-Prot
    Q6RFY2
    UniProtKB/TrEMBL
    A0A0G2K018, A6KMF0
    Conserved Domains (2) summary
    smart00707
    Location:398 → 422
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam17380
    Location:352 → 505
    DUF5401; Family of unknown function (DUF5401)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6RFY2.1 GenPept UniProtKB/Swiss-Prot:Q6RFY2

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