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    ING2 inhibitor of growth family, member 2 [ Homo sapiens ]

    Gene ID: 3622, updated on 11-May-2012

    Summary

    Official Symbol
    ING2provided by HGNC
    Official Full Name
    inhibitor of growth family, member 2provided by HGNC
    Primary source
    HGNC:6063
    See related
    Ensembl:ENSG00000168556; HPRD:05021; MIM:604215; Vega:OTTHUMG00000150502
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ING1L; p33ING2
    Summary
    This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    4q35.1
    Sequence :
    Chromosome: 4; NC_000004.11 (184426220..184432249)
    See ING2 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene vesicle transport through interaction with t-SNAREs homolog 1B (yeast) pseudogene 2 Neighboring gene uncharacterized LOC389247 Neighboring gene RWD domain containing 4 Neighboring gene trafficking protein particle complex 11

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9H160 Q09472 EP300    HPRD  PubMed  
    Q9H160 P62805 HIST2H4A    HPRD  PubMed  
    Q9H160 Q15797 SMAD1    HPRD  PubMed  
    Q9H160 Q9HCE7 SMURF1    HPRD  PubMed  
    Q9H160 Q9HAU4 SMURF2    HPRD  PubMed  
    BioGRID:109834 BioGRID:106601 ACTL6A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109834 BioGRID:111861 ARID4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109834 BioGRID:119708 ARID4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109834 BioGRID:124038 BRMS1L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109834 BioGRID:114729 COPS2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109834 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109834 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109834 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109834 BioGRID:32711 HHT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109834 BioGRID:35796 HHT2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109834 BioGRID:111142 PCNA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109834 BioGRID:111863 RBBP4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109834 BioGRID:111866 RBBP7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109834 BioGRID:122735 SAP130    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109834 BioGRID:35441 SAP30    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109834 BioGRID:114346 SAP30    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109834 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109834 BioGRID:116983 SIRT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109834 BioGRID:112389 SKIL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109834 BioGRID:110262 SMAD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109834 BioGRID:112482 SMARCB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109834 BioGRID:112483 SMARCC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109834 BioGRID:112485 SMARCC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109834 BioGRID:121411 SMURF1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:109834 BioGRID:122174 SUDS3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109834 BioGRID:113188 SUMO1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109834 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109834 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    methylated histone residue binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    chromatin modification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    male germ-line stem cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    male meiosis I ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cellular senescence NAS
    Non-traceable Author Statement
    more info
     
    regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of response to DNA damage stimulus NAS
    Non-traceable Author Statement
    more info
     
    regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    seminiferous tubule development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    CCAAT-binding factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Sin3 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    inhibitor of growth protein 2
    Names
    inhibitor of growth protein 2
    p32
    ING1Lp
    inhibitor of growth 1-like protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001564.2NP_001555.1  inhibitor of growth protein 2

      Status: VALIDATED

      Source sequence(s)
      AB012853, BC030128, BM929984
      Consensus CDS
      CCDS3833.1
      UniProtKB/Swiss-Prot
      Q9H160
      Related
      ENSP00000307183, OTTHUMP00000197671, ENST00000302327, OTTHUMT00000318652
      Conserved Domains (2) summary
      pfam12998
      Location:27125
      Blast Score: 198
      ING; Inhibitor of growth proteins N-terminal histone-binding
      cl15348
      Location:215259
      Blast Score: 97
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      184426220..184432249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      180185578..180191607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC107214.5 (39993..46022) None
    genomic AF062747.1 AAG11396.1
    genomic CH471056.2 EAX04689.1
      EAX04690.1
    mRNA AB012853.1 BAA36419.1
    mRNA AB196793.1 BAF30476.1
    mRNA AF053537.1 AAG11395.1
    mRNA AJ006851.1 CAC20567.1
    mRNA AK294310.1 BAH11731.1
    mRNA AK314000.1 BAG36712.1
    mRNA BC030128.2 AAH30128.1
    mRNA BM929984.1 None
    other-genetic HQ447773.1 ADQ32258.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H160.2 GenPept UniProtKB/Swiss-Prot:Q9H160

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