IDO1 indoleamine 2,3-dioxygenase 1 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: IDO1provided by HGNC
Official Full Name: indoleamine 2,3-dioxygenase 1provided by HGNC
Primary source: HGNC:6059
See related: Ensembl:ENSG00000131203; HPRD:00935; MIM:147435; Vega:OTTHUMG00000164057
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IDO; INDO; IDO-1
Summary: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

Help top of page

Genomic context

Location :: 8p12-p11

Sequence :: Chromosome: 8; NC_000008.10 (39771328..39786309)

See IDO1 in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via DMBT1 and IDO1
Title: A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory proteins.
expression of IDO did not correlate to histologic classification, tumor size, lymphatic invasion, venous invasion and lymph nodes metastasis, but it was correlated to clinical stage
Title: [Study of indoleamine 2,3-dioxygenase expression in patients of thyroid cancer].
upregulated expression in primary breast cancer correlates with increase of infiltrated regulatory T cells and lymph node metastasis
Title: Upregulated expression of indoleamine 2, 3-dioxygenase in primary breast cancer correlates with increase of infiltrated regulatory T cells in situ and lymph node metastasis.
Data suggest a strong association of indoleamine 2,3-dioxygenase (IDO) activity with the severity and outcome of clinical graft-versus-host disease (GVHD).
Title: Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenase.
[review] Induction of indoleamine 2, 3-dioxygenase and quinolinic acid mediates seizure activity in multiple sclerosis at least in part via an increase in interferon (IFN)gamma.
Title: Multiple sclerosis, seizures, and antiepileptics: role of IL-18, IDO, and melatonin.
ligation of TLR-3 by poly(I:C) induces IDO expression in human first-trimester trophoblasts via an IFN-beta-dependent pathway
Title: Toll-like receptor-3 ligation-induced indoleamine 2, 3-dioxygenase expression in human trophoblasts.
high expression in esophageal squamous cell carcinoma correlates with impaired overall survival time
Title: Involvement of indoleamine 2,3-dioxygenase in impairing tumor-infiltrating CD8 T-cell functions in esophageal squamous cell carcinoma.
These results suggest that the activity of IDO enzyme is insufficient in immune thrombocytopenia patients.
Title: Decreased IDO activity and increased TTS expression break immune tolerance in patients with immune thrombocytopenia.
The data suggest that IDO uses a ring-opening mechanism during N-formylkynurenine formation, rather than Criegee or dioxetane mechanisms as previously proposed.
Title: The mechanism of formation of N-formylkynurenine by heme dioxygenases.
identification of a variable number of tandem repeats polymorphism in IDO1 promoter and characterization of LEF-1 response elements
Title: Identification of a variable number of tandem repeats polymorphism and characterization of LEF-1 response elements in the promoter of the IDO1 gene.

Submit: New GeneRIF Correction See all (159)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	CCR5- or CXCR4-tropic HIV-1 induce the release of Indoleamine 2,3-dioxygenase (IDO) in plasmacytoid dendritic cells and this induction is inhibited by the blockade of HIV-1 gp120 interaction with CD4 by anti-CD4-Ab	PubMed
Vpr	vpr	HIV-1 Vpr potentiates the suppression of indoleamine 2,3-dioxygenase by glucocorticoids via the glucocorticoid receptor pathway	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
NP_002155.1			BIND	PubMed	INDO (IDO) interacts with MTH-trp.
NP_002155.1			BIND	PubMed	INDO (IDO) interacts with 1MT.
NP_002155.1			BIND	PubMed	INDO (IDO) interacts with N-Formylkynurenine.
P14902	Q9GZR7	DDX24	HPRD	PubMed
P14902	Q96I34	PPP1R16A	HPRD	PubMed
BioGRID:109832	BioGRID:124414	PPP1R16A	BioGRID	PubMed	Two-hybrid
BioGRID:109832	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
electron carrier activity	TAS Traceable Author Statement more info	PubMed
heme binding	IEA Inferred from Electronic Annotation more info
indoleamine 2,3-dioxygenase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
oxidoreductase activity	IEA Inferred from Electronic Annotation more info
tryptophan 2,3-dioxygenase activity	EXP Inferred from Experiment more info

Process	Evidence Code	Pubs
cellular nitrogen compound metabolic process	TAS Traceable Author Statement more info
female pregnancy	TAS Traceable Author Statement more info	PubMed
small molecule metabolic process	TAS Traceable Author Statement more info
tryptophan catabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytosol	TAS Traceable Author Statement more info

General protein information

Preferred Names: indoleamine 2,3-dioxygenase 1

Names: indoleamine 2,3-dioxygenase 1; indole 2,3-dioxygenase; indolamine 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase

NP_002155.1

EC 1.13.11.52

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_028155.1 RefSeqGene

Range

5001..19982

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002164.5 → NP_002155.1 indoleamine 2,3-dioxygenase 1

Status: REVIEWED

Source sequence(s)

AU137351, BC027882, BF094375, CD366252

Consensus CDS

CCDS47847.1

UniProtKB/Swiss-Prot

P14902

Related

ENSP00000430950, OTTHUMP00000225716, ENST00000518237, OTTHUMT00000376987

Conserved Domains (1) summary

pfam01231
Location:8 – 400
Blast Score: 1478

IDO; Indoleamine 2,3-dioxygenase

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000008.10 Reference GRCh37.p5 Primary Assembly

Range

39771328..39786309

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000140.1 Alternate HuRef

Range

38304038..38319017

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC007991.7 (53885..68507)	None
genomic	CH471080.2	EAW63270.1
		EAW63271.1
		EAW63272.1
genomic	HI179038.1	CBX53828.1
mRNA	AK313259.1	BAG36069.1
mRNA	AU137351.1	None
mRNA	AY221100.1	AAO34405.1
mRNA	BC027882.1	AAH27882.1
mRNA	BF094375.1	None
mRNA	CD366252.1	None
mRNA	CD690354.1	None
mRNA	JF772862.1	AEF30540.1
mRNA	M34455.1	AAA36081.1
mRNA	X17668.1	CAA35663.1
other-genetic	HQ447286.1	ADQ31773.1