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Zdhhc6 zinc finger DHHC-type palmitoyltransferase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361771, updated on 5-Mar-2024

Summary

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Official Symbol
Zdhhc6provided by RGD
Official Full Name
zinc finger DHHC-type palmitoyltransferase 6provided by RGD
Primary source
RGD:1304657
See related
Ensembl:ENSRNOG00000036576 AllianceGenome:RGD:1304657
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation; positive regulation of mitochondrial fusion; and protein targeting to membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC6 (zinc finger DHHC-type palmitoyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 223.9), Kidney (RPKM 156.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q55
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (264340883..264361435, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (254335472..254356141, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (276291411..276309633, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene extensin-like Neighboring gene glycerol-3-phosphate acyltransferase, mitochondrial Neighboring gene tectorin beta Neighboring gene guanylate cyclase 2G Neighboring gene acyl-CoA synthetase long-chain family member 5 Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene uncharacterized LOC134485256 Neighboring gene uncharacterized LOC134485255

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase. Fairbank M, et al. FEBS Lett, 2012 Jul 30. PMID 22728137
  2. Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade. Abrami L, et al. Elife, 2017 Aug 15. PMID 28826475, Free PMC Article
  3. Endoplasmic reticulum localization of DHHC palmitoyltransferases mediated by lysine-based sorting signals. Gorleku OA, et al. J Biol Chem, 2011 Nov 11. PMID 21926431, Free PMC Article
  4. Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex. Fredericks GJ, et al. Proc Natl Acad Sci U S A, 2014 Nov 18. PMID 25368151, Free PMC Article
  5. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Senyilmaz D, et al. Nature, 2015 Sep 3. PMID 26214738, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC125041

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-stearoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC6
Names
membrane-associated DHHC6 zinc finger protein
probable palmitoyltransferase ZDHHC6
zinc finger, DHHC domain containing 6
zinc finger, DHHC-type containing 6
NP_001032741.1
XP_038940605.1
XP_038940607.1
XP_038940608.1
XP_063124828.1
XP_063124843.1
XP_063124846.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037652.1 → NP_001032741.1  palmitoyltransferase ZDHHC6

    See identical proteins and their annotated locations for NP_001032741.1

    Status: PROVISIONAL

    Source sequence(s)
    BC107928
    UniProtKB/TrEMBL
    A0A8I5ZNT0, F1LQB4, Q32PY5
    Related
    ENSRNOP00000080065.1, ENSRNOT00000103424.1
    Conserved Domains (2) summary
    pfam01529
    Location:95 → 241
    DHHC; DHHC palmitoyltransferase
    pfam07653
    Location:317 → 394
    SH3_2; Variant SH3 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    264340883..264361435 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084677.2 → XP_038940605.1  palmitoyltransferase ZDHHC6 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K7F3, A6JHZ3
    Related
    ENSRNOP00000074182.2
    Conserved Domains (1) summary
    pfam01529
    Location:95 → 241
    DHHC; DHHC palmitoyltransferase

  2. XM_063268773.1 → XP_063124843.1  palmitoyltransferase ZDHHC6 isoform X5

  3. XM_039084680.2 → XP_038940608.1  palmitoyltransferase ZDHHC6 isoform X4

    UniProtKB/TrEMBL
    A6JHZ3
    Conserved Domains (1) summary
    pfam01529
    Location:95 → 241
    DHHC; DHHC palmitoyltransferase

  4. XM_063268758.1 → XP_063124828.1  palmitoyltransferase ZDHHC6 isoform X1

  5. XM_039084679.2 → XP_038940607.1  palmitoyltransferase ZDHHC6 isoform X3

    UniProtKB/TrEMBL
    A6JHZ3
    Conserved Domains (1) summary
    pfam01529
    Location:95 → 241
    DHHC; DHHC palmitoyltransferase

  6. XM_063268776.1 → XP_063124846.1  palmitoyltransferase ZDHHC6 isoform X6

Nucleotide Protein Strain
Heading Accession and Version

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