IMPA2 inositol monophosphatase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IMPA2provided by HGNC
Official Full Name: inositol monophosphatase 2provided by HGNC
Primary source: HGNC:HGNC:6051
See related: Ensembl:ENSG00000141401 MIM:605922; AllianceGenome:HGNC:6051
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]
Expression: Broad expression in kidney (RPKM 73.3), skin (RPKM 38.8) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 18p11.21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	18	NC_000018.10 (11981507..12030877)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	18	NC_060942.1 (12144221..12193612)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	18	NC_000018.9 (11981506..12030876)

Chromosome 18 - NC_000018.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IMPA2 promotes basal-like breast cancer aggressiveness by a MYC-mediated positive feedback loop.
Title: IMPA2 promotes basal-like breast cancer aggressiveness by a MYC-mediated positive feedback loop.
A novel function of IMPA2, plays a tumor-promoting role in cervical cancer.
Title: A novel function of IMPA2, plays a tumor-promoting role in cervical cancer.
We conclude that miR-25-mediated IMPA2 downregulation constitutes a novel signature for cancer metastasis and poor outcomes in clear cell renal cell carcinoma (ccRCC). We further postulate that the therapeutic targeting of miR-25 can be useful for preventing the metastatic progression of ccRCC associated with IMPA2 downregulation.
Title: Dysregulation of the miR-25-IMPA2 axis promotes metastatic progression in clear cell renal cell carcinoma.
IMPA2 is a protein-coding gene for a catalytic protein that converts inositol monophosphate into free inositol through dephosphorylation.
Title: Association between genetic variation in the myo-inositol monophosphatase 2 (IMPA2) gene and age at onset of bipolar disorder.
a correlation between an IMPA2 polymorphism rs589247 and ischemic stroke risk in a northwest Han Chinese
Title: IMPA2 polymorphisms and risk of ischemic stroke in a northwest Han Chinese population.
a promoter polymorphism of IMPA2 possibly contributed to risk for schizophrenia by elevating transcription activity in Han Chinese individuals.
Title: A promoter polymorphism rs2075824 within IMPA2 gene affecting the transcription activity: possible relationship with schizophrenia.
results suggest that genetic variability at rs669838-IMPA2,rs4853694-INPP1, rs1732170-GSK3b and rs11921360-GSK3b genes is associated with a higher risk of attempting suicide in bipolar patients.
Title: Genetic variability at IMPA2, INPP1 and GSK3β increases the risk of suicidal behavior in bipolar patients.
Authors propose that the human myo-inositol monophosphatase 2 interacts with myo-inositol monophosphates in the three-metal-ion bound form, and proceeds the dephosphorylation through the three-metal-ion theory.
Title: In silico study on the substrate binding manner in human myo-inositol monophosphatase 2.
No association is found between IMPA2 gene polymorphisms and bipolar disorder.
Title: Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder.
The current study did not support a substantial role of the upregulation of IMPase in bipolar disorder, although the lithium-insensitivity trait seen in IMPA2 transgenic mice might represent some aspect relevant to the inositol depletion hypothesis.
Title: Behavioral analyses of transgenic mice harboring bipolar disorder candidate genes, IMPA1 and IMPA2.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

A006N05 (e-PCR)
- UniSTS:20535

D18S1066 (e-PCR)
- UniSTS:72539

G35510 (e-PCR)
- UniSTS:44150

RH36905 (e-PCR)
- UniSTS:87932

RH64924 (e-PCR)
- UniSTS:46462

L29953 (e-PCR)
- UniSTS:52164

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables inositol monophosphate 1-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol monophosphate 1-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol monophosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables inositol monophosphate 4-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in inositol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in inositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphate-containing compound metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in response to lithium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: inositol monophosphatase 2

Names: IMP 2; IMPase 2; inosine monophosphatase 2; inositol(myo)-1(or 4)-monophosphatase 2; myo-inositol monophosphatase 2; myo-inositol monophosphatase A2

NP_055029.1

EC 3.1.3.25

XP_011523961.1

EC 3.1.3.25

XP_054174529.1

EC 3.1.3.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_028104.1 RefSeqGene

Range

5052..54422

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_014214.3 → NP_055029.1 inositol monophosphatase 2

See identical proteins and their annotated locations for NP_055029.1

Status: REVIEWED

Source sequence(s)

AP001269, BC017176

Consensus CDS

CCDS11855.1

UniProtKB/Swiss-Prot

B0YJ29, O14732, Q9UJT3

Related

ENSP00000269159.3, ENST00000269159.8

Conserved Domains (1) summary

cd01639
Location:19 → 265

IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000018.10 Reference GRCh38.p14 Primary Assembly

Range

11981507..12030877

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011525659.4 → XP_011523961.1 inositol monophosphatase 2 isoform X1

Conserved Domains (1) summary

cd01639
Location:62 → 249

IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...