Mat1 [Drosophila melanogaster] - Gene

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Summary

Official Symbol: Mat1provided by Flybase
Primary source: FLYBASE:FBgn0024956
Locus tag: Dmel_CG7614
Gene type: protein coding
RNA name: Mat1
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AT-1; CG7614; Dmel\CG7614; MAT1

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Genomic context

Location :: 47B9-47B9

Sequence :: Chromosome: 2R; NT_033778.3 (6626122..6627339, complement)

See Mat1 in Epigenomics, MapViewer

Chromosome 2R - NT_033778.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:61939	BioGRID:63867	CG11486	BioGRID	PubMed	Two-hybrid
BioGRID:61939	BioGRID:58656	CG12723	BioGRID	PubMed	Two-hybrid
BioGRID:61939	BioGRID:77508	CG33109	BioGRID	PubMed	Two-hybrid
BioGRID:61939	BioGRID:57951	Cdk7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:61939	BioGRID:65669	CycH	BioGRID	PubMed	Affinity Capture-MS
BioGRID:61939	BioGRID:61444	EcR	BioGRID	PubMed	Two-hybrid
BioGRID:61939	BioGRID:63168	Liprin-gamma	BioGRID	PubMed	Two-hybrid
BioGRID:61939	BioGRID:59479	MED15	BioGRID	PubMed	Two-hybrid
BioGRID:61939	BioGRID:65742	Mes2	BioGRID	PubMed	Two-hybrid
BioGRID:61939	BioGRID:59992	Vm26Ab	BioGRID	PubMed	Two-hybrid
BioGRID:61939	BioGRID:62866	ena	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the Mat1 gene: The Mat1 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , and N.crassa.

Pathways from BioSystems

Basal transcription factors, organism-specific biosystem (from KEGG)
Basal transcription factors, organism-specific biosystem
Basal transcription factors
Basal transcription factors, conserved biosystem (from KEGG)
Basal transcription factors, conserved biosystem
Basal transcription factors
DNA Repair, organism-specific biosystem (from REACTOME)
DNA Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dual incision reaction in GG-NER, organism-specific biosystem (from REACTOME)
Dual incision reaction in GG-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dual incision reaction in TC-NER, organism-specific biosystem (from REACTOME)
Dual incision reaction in TC-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Eukaryotic Transcription Initiation, organism-specific biosystem (from WikiPathways)
Eukaryotic Transcription Initiation, organism-specific biosystemIn eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the pre...
Formation of RNA Pol II elongation complex, organism-specific biosystem (from REACTOME)
Formation of RNA Pol II elongation complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Formation of incision complex in GG-NER, organism-specific biosystem (from REACTOME)
Formation of incision complex in GG-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Formation of the Early Elongation Complex, organism-specific biosystem (from REACTOME)
Formation of the Early Elongation Complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Global Genomic NER (GG-NER), organism-specific biosystem (from REACTOME)
Global Genomic NER (GG-NER), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Holo-TFIIH complex, organism-specific biosystem (from KEGG)
Holo-TFIIH complex, organism-specific biosystemStructural complex; Genetic information processing; Repair system
Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
Nucleotide Excision Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nucleotide excision repair, organism-specific biosystem (from KEGG)
Nucleotide excision repair, organism-specific biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
Nucleotide excision repair, conserved biosystem (from KEGG)
Nucleotide excision repair, conserved biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
RNA Pol II CTD phosphorylation and interaction with CE, organism-specific biosystem (from REACTOME)
RNA Pol II CTD phosphorylation and interaction with CE, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Pre-transcription Events, organism-specific biosystem (from REACTOME)
RNA Polymerase II Pre-transcription Events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Promoter Escape, organism-specific biosystem (from REACTOME)
RNA Polymerase II Promoter Escape, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Elongation, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Initiation, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Initiation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Initiation And Promoter Clearance, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Initiation And Promoter Clearance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, organism-specific biosystem (from REACTOME)
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transcription-coupled NER (TC-NER), organism-specific biosystem (from REACTOME)
Transcription-coupled NER (TC-NER), organism-specific biosystemcomputationally inferred pathway (not manually curated)
mRNA Capping, organism-specific biosystem (from REACTOME)
mRNA Capping, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to RNA polymerase II carboxy-terminal domain kinase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to cyclin-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cell cycle	IEA Inferred from Electronic Annotation more info
transcription initiation from RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
carboxy-terminal domain protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
holo TFIIH complex	IDA Inferred from Direct Assay more info	PubMed
holo TFIIH complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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General protein information

Preferred Names: CG7614 gene product from transcript CG7614-RA

Names: CG7614-PA; Mat1; Mat1-PA

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.3

Range

6626122..6627339, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_136761.2 → NP_610605.1 Mat1 [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q7KPG8

Related

FBpp0087350, FBtr0088255

Conserved Domains (2) summary

TIGR00570
Location:1 – 313
Blast Score: 1136

cdk7; CDK-activating kinase assembly factor MAT1

cl15348
Location:6 – 49
Blast Score: 100

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...